[Binding of cortisol, fluocortolone and difluocortolone to human plasma proteins (author's transl)]. / Bindung von cortisol, Fluocortolon und Difluocortolon an Humanplasmaproteine.
J Clin Chem Clin Biochem
; 15(10): 545-8, 1977 Oct.
Article
em De
| MEDLINE
| ID: mdl-925615
ABSTRACT
The binding properties of [3H]cortisol, [3H]fluocortolone and [3H]difluocortolone by human plasma, human albumin, human- beta- and gamma-globulins have been studied by equilibrium dialysis. Cortisol, in physiological concentrations (0,4 micromol/l), is 98% bound in human plasma at 25 degrees C, fluocortolone 96% and diflucortolone 85%. Uncer physiological conditions cortisol is mainly bound to the corticosteroid binding globulin (transcortin). 2/3 of fluocortolone is bound to transcortin and 1/3 to albumin and globulins, whereas difluocortolone is mainly bound to albumin and to globulins but not to transcortin. The binding affinities of beta- and gamma-globulins are -ery low for the corticoids investigated, but they are higher for fluocortolone and difluocortolone than for cortisol.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pregnadienodiois
/
Fluocortolona
/
Hidrocortisona
/
Proteínas de Transporte
Limite:
Humans
Idioma:
De
Revista:
J Clin Chem Clin Biochem
Ano de publicação:
1977
Tipo de documento:
Article