Suppressive effects of tranilast on the expression of inducible cyclooxygenase (COX2) in interleukin-1beta-stimulated fibroblasts.
Biochem Pharmacol
; 53(12): 1941-4, 1997 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-9256170
ABSTRACT
We investigated the effects of tranilast on inducible cyclooxygenase (COX2)-mediated prostaglandin E2 (PGE2) production and enzyme induction in interleukin-lbeta (IL-1beta)-stimulated cultured dermal fibroblasts. IL-1beta enhanced PGE2 production in cultured fibroblasts. Tranilast did not affect constitutive cyclooxygenase (COX1) or COX2 activity in non-stimulated or IL-lbeta-stimulated fibroblasts. However, the COX2 expression induced by IL-1beta was inhibited by tranilast. This result, that IL-1beta-induced COX2 expression was suppressed by tranilast, was confirmed by immunohistochemical analysis. Thus, it is possible for tranilast to regulate PGE2 production by inhibiting COX2 induction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dinoprostona
/
Interleucina-1
/
Prostaglandina-Endoperóxido Sintases
/
Antialérgicos
/
Ortoaminobenzoatos
/
Isoenzimas
Limite:
Humans
Idioma:
En
Revista:
Biochem Pharmacol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Japão