DNA hypomethylation in breast cancer: an independent parameter of tumor progression?
Cancer Genet Cytogenet
; 97(2): 83-9, 1997 Sep.
Article
em En
| MEDLINE
| ID: mdl-9283586
ABSTRACT
The global DNA methylation status was investigated on a series of 59 breast cancers by Southern blotting, using methylation sensitive restriction enzymes. By comparison to control DNA, almost all tumor DNAs were found globally hypomethylated. However, the demethylation was variable from tumor to tumor. Compared to other biological parameters, the methylation did not correlate with chromosome alterations, steroid hormone receptor status, or histopathological grading. Tumors which appeared to be the most evolved for other parameters were only mildly hypomethylated, whereas tumors with strongly hypomethylated DNA corresponded to those with slight alterations of the other parameters. Thus, DNA hypomethylation is a consistent characteristic of breast cancer, but its variations may not correlate with tumor progression of most breast cancers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
DNA de Neoplasias
/
Carcinoma Ductal de Mama
/
Metilação de DNA
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
França