[The effects of hormone replacement therapy (HRT) on lipid metabolism in the menopause]. / Effetti della terapia ormonale sostitutiva (HRT) sul metabolismo lipidico in menopausa.
Minerva Ginecol
; 49(5): 199-202, 1997 May.
Article
em It
| MEDLINE
| ID: mdl-9304079
ABSTRACT
INTRODUCTION AND AIMS:
During menopause the number of cardiovascular attacks increases parallel to the elimination of estradiol production. The administration of the latter reverses this tendency owing to a compound mechanism (improved HDL) cholesterol/total cholesterol ratio, diminished vasal resistance). MATERIALS ANDMETHODS:
The authors present a study performed in 34 patients in menopause receiving oestroprogestinic replacement therapy using an oral or transdermal route. Metabolic status (serum concentrations of total cholesterol (TC) and HDL cholesterol (C.HDL) was evaluated in all patients before treatment and after 12 months.RESULTS:
A statistically significant positive correlation (p < 0.0001) was found between the use of oestrogen and serum levels of HDL. This correlation appeared to be more evident in patients using transdermal treatment compared to the oral form.CONCLUSIONS:
The authors conclude that in the absence of contraindications, hormone replacement therapy in menopause exercises a beneficial effect on the lipid status, contributing to diminishing the risk of cardiovascular attacks. The possibility of an increased incidence of breast cancer is now being evaluated, whereas effective protection of the endometrium against the risk of hyperplasia and cancer was shown using the doses of progestin used in this study, which coincide with those currently prescribed in the literature.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Progestinas
/
Menopausa
/
Terapia de Reposição de Estrogênios
/
Estrogênios Conjugados (USP)
/
Estradiol
/
Lipídeos
Limite:
Female
/
Humans
/
Middle aged
Idioma:
It
Revista:
Minerva Ginecol
Ano de publicação:
1997
Tipo de documento:
Article