Mutations in the gyrA and parC genes associated with fluoroquinolone resistance in clinical isolates of Citrobacter freundii.
FEMS Microbiol Lett
; 154(2): 409-14, 1997 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-9311142
ABSTRACT
We determined partial sequences of the gyrA and parC genes of Citrobacter freundii type strain, and then examined 38 C. freundii clinical strains isolated from patients with urinary tract infections for the association of alterations in GyrA and ParC with susceptibility to fluoroquinolones. Our results suggest that in C. freundii DNA gyrase may be a primary target of quinolones, that an amino acid change at Thr-83 or Asp-87 in GyrA is sufficient to decrease susceptibility to fluoroquinolones, and that accumulation of changes in GyrA with the simultaneous presence of an alteration at Ser-80 or Glu-84 in ParC may be associated with the development of high-level fluoroquinolone resistance in C. freundii clinical isolates.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citrobacter freundii
/
DNA Topoisomerases Tipo II
/
Genes Bacterianos
/
Anti-Infecciosos
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
FEMS Microbiol Lett
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Japão