[Clinical utility of available diagnostic tests in prostatic carcinoma. Results of 500 biopsies. I. PSA, PSA density, and predicted PSA]. / Utilidad clínica de las pruebas diagnósticas disponibles en el carcinoma prostático. Resultados sobre 500 biopsias. Parte I: PSA, densidad de PSA y PSA predecible.
Arch Esp Urol
; 50(4): 333-8, 1997 May.
Article
em Es
| MEDLINE
| ID: mdl-9313041
ABSTRACT
OBJECTIVE:
To study the utility of PSA density and predicted PSA results in the diagnosis of prostatic cancer using gland volume.METHODS:
500 patients suspected as having prostatic cancer underwent ultrasound-guided transrectal biopsy. Prostate volume and ultrasound characteristics, serum PSA density, predicted PSA and the difference between both were determined.RESULTS:
44.8% of the patients showed evidence of cancer in the biopsy specimen. These patients had a significantly smaller prostate. The 0.1 and 0.15 PSA density cutoffs had a sensitivity of 96% and 94%, specificity of 10% and 20% and positive predictive value of 46% and 49%, respectively. The statistical values for PSA difference of 1 and 2 were 94% and 92%, 13% and 18%, 47% and 48%, respectively.CONCLUSION:
PSA density and predicted PSA results could be useful to avoid biopsies in patients with PSA between 4 and 10 ng/ml and no malignant tumor of the prostate.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Próstata
/
Neoplasias da Próstata
/
Biópsia por Agulha
/
Adenocarcinoma
/
Biomarcadores Tumorais
/
Antígeno Prostático Específico
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
Idioma:
Es
Revista:
Arch Esp Urol
Ano de publicação:
1997
Tipo de documento:
Article