Antibacterial activity of AM-1155 against penicillin-resistant Streptococcus pneumoniae.
J Antimicrob Chemother
; 41(1): 103-6, 1998 Jan.
Article
em En
| MEDLINE
| ID: mdl-9511043
ABSTRACT
AM-1155, a novel fluoroquinolone, exhibited potent activity against Streptococcus pneumoniae, including penicillin-resistant strains; the MIC90 for 48 clinical isolates was 0.25 mg/L. The antibacterial activity of AM-1155 against S. pneumoniae was higher than that of levofloxacin (MIC90 1 mg/L) and comparable with that of sparfloxacin. The MIC90s of penicillin G and erythromycin were 2 and > 4 mg/L, respectively. AM-1155 showed no cross-resistance to penicillin or erythromycin. For experimental murine pneumonia with S. pneumoniae intermediately resistant to penicillin, oral administration of AM-1155 showed efficacy higher than that of levofloxacin and equal to that of sparfloxacin. The efficacy of AM-1155 was also equal to that of subcutaneous penicillin G administration at the same dosage.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Infecções Pneumocócicas
/
Streptococcus pneumoniae
/
Quinolonas
/
Fluoroquinolonas
/
Anti-Infecciosos
Limite:
Animals
Idioma:
En
Revista:
J Antimicrob Chemother
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Japão