Soluble Fc gamma receptors: interaction with ligands and biological consequences.
Int Rev Immunol
; 16(1-2): 87-111, 1997.
Article
em En
| MEDLINE
| ID: mdl-9651787
ABSTRACT
Soluble Fc gamma receptors are produced by cleavage of the membrane receptors or by alternative splicing. They are found in biologic fluids. After a brief description of the structure and mode of production of soluble Fc gamma R, we address the question of ligands and function of the soluble Fc gamma R by using recombinant molecules and transgenic animals. We show that soluble Fc gamma R are not only IgG-binding factors which interfere with, and block, Fc-dependent immune reactions but also molecules that interact, in vitro, with non-Ig-ligands such as CR3 and CR4 and are trigger or regulate immune functions via these receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de IgG
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Int Rev Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
França