Cell cycle arrest by Vpr in HIV-1 virions and insensitivity to antiretroviral agents.
Science
; 281(5374): 266-9, 1998 Jul 10.
Article
em En
| MEDLINE
| ID: mdl-9657723
ABSTRACT
Expression of human immunodeficiency virus-type 1 (HIV-1) Vpr after productive infection of T cells induces cell cycle arrest in the G2 phase of the cell cycle. In the absence of de novo expression, HIV-1 Vpr packaged into virions still induced cell cycle arrest. Naturally noninfectious virus or virus rendered defective for infection by reverse transcriptase or protease inhibitors were capable of inducing Vpr-mediated cell cycle arrest. These results suggest a model whereby both infectious and noninfectious virions in vivo, such as those surrounding follicular dendritic cells, participate in immune suppression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fase G2
/
HIV-1
/
Produtos do Gene vpr
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos