Assembly and disassembly of DNA polymerase holoenzyme.
Curr Opin Chem Biol
; 1(3): 316-22, 1997 Oct.
Article
em En
| MEDLINE
| ID: mdl-9667868
ABSTRACT
The complex task of genomic replication requires a large collection of proteins properly assembled within the close confines of the replication fork. The mechanism and dynamics of holoenzyme assembly and disassembly have been investigated using steady state and pre-steady state methods as opposed to structural studies, primarily due to the intrinsic transient nature of these protein complexes during DNA replication. The key step in bacteriophage T4 holoenzyme assembly involves ATP hydrolysis, whereas disassembly is mediated by subunit dissociation of the clamp protein in an ATP-independent manner.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Coenzimas
/
DNA Polimerase Dirigida por DNA
Idioma:
En
Revista:
Curr Opin Chem Biol
Assunto da revista:
BIOQUIMICA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos