Auto-ADP-ribosylation of NAD glycohydrolase from Neurospora crassa.
Comp Biochem Physiol B Biochem Mol Biol
; 120(1): 175-81, 1998 May.
Article
em En
| MEDLINE
| ID: mdl-9787786
ABSTRACT
NAD glycohydrolase (NADase; EC 3.2.2.5) is an enzyme that catalyzes hydrolysis of NAD to produce ADP-ribose and nicotinamide. We recently demonstrated that self-inactivation of NADase from rabbit erythrocytes was due to an auto-ADP-ribosylation. In the present study, a mechanism of self-inactivation of NADase from Neurospora crassa by its substrate was investigated by using intact mycelia of N. crassa and purified NADase, which had molecular characteristics different from mammalian NADases. The results suggested that inactivation of NADase from N. crassa was also due to an auto-ADP-ribosylation. These findings indicate that the auto-modification of NADase is one of the universal phenomena to regulate enzyme functions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
NAD/ Nucleosidase
/
NAD
/
Neurospora crassa
Idioma:
En
Revista:
Comp Biochem Physiol B Biochem Mol Biol
Assunto da revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Coréia do Sul