Analysis of a Zebrafish semaphorin reveals potential functions in vivo.
Dev Dyn
; 214(1): 13-25, 1999 Jan.
Article
em En
| MEDLINE
| ID: mdl-9915572
ABSTRACT
The semaphorin/collapsin gene family is a large and diverse family encoding both secreted and transmembrane proteins, some of which are thought to act as repulsive axon guidance molecules. However, the function of most semaphorins is still unknown. We have cloned and characterized several semaphorins in the zebrafish in order to assess their in vivo function. Zebrafish semaZ2 is expressed in a dynamic and restricted pattern during the period of axon outgrowth that indicates potential roles in the guidance of several axon pathways. Analysis of mutant zebrafish with reduced semaZ2 expression reveals axon pathfinding errors that implicate SemaZ2 in normal guidance.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Peixe-Zebra
/
Fatores de Crescimento Neural
/
Proteínas do Tecido Nervoso
Limite:
Animals
Idioma:
En
Revista:
Dev Dyn
Assunto da revista:
ANATOMIA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos