[Tuberculosis in AIDS patients: the contribution of an analysis of the restriction fragment length polymorphism of Mycobacterium tuberculosis isolates]. / Tuberculosis en pacientes con SIDA: aportación del análisis de los fragmentos de restricción de longitud polimórfica aislados de Mycobacterium tuberculosis.
Med Clin (Barc)
; 111(19): 721-4, 1998 Dec 05.
Article
em Es
| MEDLINE
| ID: mdl-9922953
ABSTRACT
BACKGROUND:
In this report we study tuberculosis transmission in HIV infected patients using molecular epidemiological methods. PATIENTS ANDMETHODS:
We have studied 60 M. tuberculosis isolates from 30 HIV infected cases, and their clinical-epidemiological data. Susceptibility to tuberculostatic agents and electrophoretic patterns using RFLPs (restriction fragment length polymorphisms) method were evaluated. Dice's coefficient was used for the similarity analysis.RESULTS:
Over 73% studied patients were included in clusters using RFLPs analysis. This data show that nearly 60% of the tuberculosis cases in our area have a recent transmission. Forty per cent of these cases were included in the main cluster. The frequency of tuberculostatic-resistant strains in HIV infected patients was similar to the that of observed in other patients. We did not find correlation between RFLPs clusters and clinical-epidemiological data.CONCLUSIONS:
Tuberculosis transmission in HIV-positive patients using RFLPs as molecular marker shows that 60% of the cases are caused by recently acquired strains. We did not find multi-drug resistant strains in our isolates. However due to the high transmissibility of these circulating clones, control disease measures in this group of risk population are required.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose Pulmonar
/
Polimorfismo de Fragmento de Restrição
/
HIV-1
/
Infecções Oportunistas Relacionadas com a AIDS
/
Mycobacterium tuberculosis
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Es
Revista:
Med Clin (Barc)
Ano de publicação:
1998
Tipo de documento:
Article