Asbestos and DNA double strand breaks.
Cancer Res
; 59(2): 298-300, 1999 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-9927035
ABSTRACT
A radiosensitive DNA repair-deficient xrs-5 cell line was used to study asbestos cytotoxicity and DNA double strand breaks (DSBs). Although xrs-5 cells did not show any increase in sensitivity to chrysotile fibers in short-term (4-h) treatment when compared with wild-type CHO cells, longer-term exposure (24 h) gave significantly lower cell survival accompanied by a cell growth delay as well as a higher DNA DSB induction in this mutant cell line. These results suggest an important role played by DNA DSBs at the initial stage of asbestos injury.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Amianto
/
Dano ao DNA
/
DNA
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos