Apolipoprotein B gene polymorphisms in people in the East Mediterranean area of Turkey
(East. Mediterr. health j).
em En
| WHOLIS
| ID: who-119390
Biblioteca responsável:
CH1.1
ABSTRACT
Point mutations in the receptor binding domain of low density lipoprotein may increase cholesterol levels in blood. Three mutations of Apo B-100 protein result in defective binding [Arg 3500 ----> [corrected] Gln, Arg 3500 ----> [corrected] Trp and Arg 3531 ----> [corrected] Cys]. We estimated the frequency of Apo B point mutations [codon 3500] C9774T [Arg 3500 ----> [corrected] Trp] and G9775A [Arg 3500 ----> [corrected] Gln] in 179 atherosclerotic, 145 hyperlipidaemic individuals and 272 healthy individuals in the east Mediterranean region of Turkey. Lipid and lipoprotein levels were measured with routine biochemical analyser and Apo B mutation was detected using real-time PCR. Neither mutation was found. In this region, Apo B-100 protein mutations are rare and causes of hyperlipidaemia and atherosclerosis may therefore be unrelated to them
Palavras-chave
Texto completo:
1
Coleções:
04-international_org
Base de dados:
WHOLIS
Assunto principal:
Apolipoproteínas A
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Apolipoproteínas B
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Arteriosclerose
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Estudos de Casos e Controles
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Causalidade
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Doenças Raras
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Apolipoproteína B-100
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Frequência do Gene
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HDL-Colesterol
Idioma:
En
Revista:
East. Mediterr. health j
Ano de publicação:
2004