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1.
J Nerv Ment Dis ; 212(3): 152-158, 2024 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-38090971

RESUMEN

ABSTRACT: The purpose of this study was to evaluate emotion dysregulation and temperament-character traits in adolescents with functional neurological symptom disorder (FNSD). Forty adolescents with FNSD and 40 healthy adolescents were evaluated by a semiconstructed diagnosis interview, Temperament and Character Inventory (TCI), Difficulties in Emotion Regulation Scale (DERS), Regulation of Emotions Questionnaire (REQ), and Children's Somatization Inventory-24 (CSI-24). The external and internal dysfunctional emotion regulation scores of REQ, all subscales of DERS, except the awareness subscale, and CSI-24 scores were significantly higher in FNSD patients compared with healthy controls. There were significant differences between the groups in terms of harm avoidance and reward dependence subscale scores of TCI. Multiple logistic regression analysis showed that the external dysfunctional emotion regulation strategy, somatization, and reward dependence are significant predictors of FNSD. Our results provide evidence that adolescents with FNSD experience emotional dysregulation and that the differential value of some temperament-character traits in the diagnosis of FNSD.


Asunto(s)
Trastornos de Conversión , Temperamento , Niño , Humanos , Adolescente , Carácter , Trastornos Disociativos , Inventario de Personalidad
2.
Angew Chem Int Ed Engl ; 63(18): e202317058, 2024 Apr 24.
Artículo en Inglés | MEDLINE | ID: mdl-38369613

RESUMEN

Multi-principal element alloys (MPEAs) are gaining interest in corrosion and electrocatalysis research due to their electrochemical stability across a broad pH range and the design flexibility they offer. Using the equimolar CrCoNi alloy, we observe significant metal dissolution in a corrosive electrolyte (0.1 M NaCl, pH 2) concurrently with the oxygen evolution reaction (OER) in the transpassive region, despite the absence of hysteresis in polarization curves or other obvious corrosion indicators. We present a characterization scheme to delineate the contribution of OER and alloy dissolution, using scanning electrochemical microscopy (SECM) for OER-onset detection, and quantitative chemical analysis with inductively coupled-mass spectrometry (ICP-MS) and ultraviolet visible light (UV/Vis) spectrometry to elucidate metal dissolution processes. In situ electrochemical atomic force microscopy (EC-AFM) revealed that the transpassive metal dissolution on CrCoNi is dominated by intergranular corrosion. These results have significant implications for the stability of MPEAs in corrosion systems, emphasizing the necessity of analytically determining metal ions released from MPEA electrodes into the electrolyte when evaluating Faradaic efficiencies of OER catalysts. The release of transition metal ions not only reduces the Faradaic efficiency of electrolyzers but may also cause poisoning and degradation of membranes in electrochemical reactors.

3.
BMC Med Educ ; 23(1): 651, 2023 Sep 08.
Artículo en Inglés | MEDLINE | ID: mdl-37684677

RESUMEN

BACKGROUND: Physiotherapists show a positive attitude towards playing games in order to be a role model for pediatric patients and to increase the success of therapy. The aim of the present study is to investigate the physical playfulness of physiotherapy students and the relationship of physical playfulness and individual and environmental factors. METHODS: The sociodemographic data, regular physical activity habits of the students were examined as well as their computer game playing status and duration. "Attitudes of 18-22 Age Adults for Playing Games That Contain Physical Activity" scale was used for assessing playfulness. RESULTS: A total of 268 students participated in the study. Among the game proneness scale subsections, the highest score was obtained in the Social Adjustment while the lowest scores were obtained in the "Desire to Play Game" and "To take pleasure from playing game" subsections. Male students scored higher in "Risk Taking and "To take pleasure from playing game" in comparison with the female students. There was a statistically significant difference between physical activity habits and "Game Compassion", "Risk Taking", "Social Adjustment" and "To take pleasure from playing game scores". CONCLUSION: Physiotherapy students were found to be more playful, particularly in terms of social adaptation. Men take more risks in the plays and also play the games more enjoyable. Students with regular physical activity habits were more playful overall. The present study suggests that monitoring physical activity levels, computer games types might be beneficial for evaluating the playfulness.


Asunto(s)
Medicina , Fisioterapeutas , Adulto , Humanos , Femenino , Masculino , Niño , Modalidades de Fisioterapia , Ejercicio Físico , Estudiantes
4.
Int Wound J ; 20(6): 1893-1902, 2023 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-36535803

RESUMEN

Pressure ulcers can develop in bedridden or immobile patients which physiotherapists frequently encounter. Although physiotherapists receive training for preventing pressure ulcers, there is limited evidence of physiotherapists' knowledge level. Our study evaluated physiotherapists' pressure ulcer prevention knowledge. The level of knowledge for pressure ulcer prevention was inquired with the Turkish version of the Pressure Ulcer Prevention Knowledge Assessment Instrument (PUPKAI-T). Two hundred and sixty-five physiotherapists participated in our study. The median PUPKAI-T total score ranged from 8 to 21. Only two physiotherapists (0.8%) got good points from the questionnaire. The highest score was Nutrition (Theme 4; 59.2%), and the lowest score belonged to the contact preventive interventions that reduce pressure/shearing (Theme 5; 26.7%). The question with the lowest success rate was the positioning question of Theme 5 (Question 2; 12.5%). In our study, physiotherapists' pressure ulcer prevention knowledge was evaluated with a relatively high number of participants compared to the literature. These results brought to mind that training programs that specifically emphasise techniques to prevent pressure ulcers and positioning manoeuvres to be organised increase the knowledge level of physiotherapists.


Asunto(s)
Fisioterapeutas , Úlcera por Presión , Humanos , Úlcera por Presión/prevención & control , Cuidados de la Piel , Encuestas y Cuestionarios , Conocimientos, Actitudes y Práctica en Salud
5.
Psychol Med ; 52(14): 3267-3279, 2022 10.
Artículo en Inglés | MEDLINE | ID: mdl-33557980

RESUMEN

BACKGROUND: The symptoms of obsessive-compulsive disorder (OCD) are highly heterogeneous and it is unclear what is the optimal way to conceptualize this heterogeneity. This study aimed to establish a comprehensive symptom structure model of OCD across the lifespan using factor and network analytic techniques. METHODS: A large multinational cohort of well-characterized children, adolescents, and adults diagnosed with OCD (N = 1366) participated in the study. All completed the Dimensional Yale-Brown Obsessive-Compulsive Scale, which contains an expanded checklist of 87 distinct OCD symptoms. Exploratory and confirmatory factor analysis were used to outline empirically supported symptom dimensions, and interconnections among the resulting dimensions were established using network analysis. Associations between dimensions and sociodemographic and clinical variables were explored using structural equation modeling (SEM). RESULTS: Thirteen first-order symptom dimensions emerged that could be parsimoniously reduced to eight broad dimensions, which were valid across the lifespan: Disturbing Thoughts, Incompleteness, Contamination, Hoarding, Transformation, Body Focus, Superstition, and Loss/Separation. A general OCD factor could be included in the final factor model without a significant decline in model fit according to most fit indices. Network analysis showed that Incompleteness and Disturbing Thoughts were most central (i.e. had most unique interconnections with other dimensions). SEM showed that the eight broad dimensions were differentially related to sociodemographic and clinical variables. CONCLUSIONS: Future research will need to establish if this expanded hierarchical and multidimensional model can help improve our understanding of the etiology, neurobiology and treatment of OCD.


Asunto(s)
Trastorno Obsesivo Compulsivo , Adulto , Adolescente , Niño , Humanos , Trastorno Obsesivo Compulsivo/diagnóstico , Análisis Factorial , Determinación de la Personalidad
6.
Nord J Psychiatry ; 76(1): 64-70, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-34151723

RESUMEN

BACKGROUND: Although autism spectrum disorder (ASD) is known to include problems relating to nutrition, information about nutritional behavior, caregiver feeding styles, and anthropometric measurements is still limited. AIMS: We aimed to assess the nutritional behavior, anthropometric measurements, and caregiver feeding styles of children with ASD. METHOD: One hundred and four children with ASD and 100 controls were enrolled in the study. Children's weight and height were measured and recorded by the researchers. The Children's Eating Behavior Questionnaire, Parental Feeding Style Questionnaire, Development Assessment Form, and Sociodemographic Data Form were conducted by their caregivers. RESULTS: Children with ASD were difficult to feed as babies, experienced more problems in the transition to supplementary food, were more selective about food, and were fed diets with a more limited variety than the control group. The BMI z-scores for children with ASD were higher than those for children without ASD, while their height z-scores were lower. Children with ASD displayed more responsiveness to food, emotional overeating, enjoyment of food, desire for drinks, emotional undereating, and food selectivity behaviors, while the parents of these children were found to use more emotional feeding, instrumental feeding, and tolerance-controlled feeding styles than the parents of the controls. CONCLUSIONS: Children with ASD are more selective about foods and have greater difficulty in switching to supplementary food. The BMI-z score for children with ASD is higher and the height-z score is lower. Children with ASD have different eating and feeding styles compared to children in the control group.


Asunto(s)
Trastorno del Espectro Autista , Estudios de Casos y Controles , Niño , Conducta Alimentaria , Humanos , Padres , Encuestas y Cuestionarios
7.
J Child Sex Abus ; 31(1): 73-85, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-33206583

RESUMEN

The most common diagnoses after childhood sexual abuse are Post-Traumatic Stress Disorder and depression. The aim of this study is to design a decision support system to help psychiatry physicians in the treatment of childhood sexual abuse. Computer aided decision support system (CADSS) based on ANN, which predicts the development of PTSD and Major Depressive Disorder, using different parameters of the act of abuse and patients was designed. The data of 149 girls and 21 boys who were victims of sexual abuse were included in the study. In the designed CADDS, the gender of the victim, the type of sexual abuse, the age of exposure, the duration until reporting, the time of abuse, the proximity of the abuser to the victim, number of sexual abuse, whether the child is exposed to threats and violence during the abuse, the person who reported the event, and the intelligence level of the victim are used as input parameters. The average accuracy values for all three designed systems were calculated as 99.2%. It has been shown that the system designed by using these data can be used safely in the psychiatric assessment process, in order to differentiate psychiatric diagnoses in the early post-abuse period.


Asunto(s)
Abuso Sexual Infantil , Trastorno Depresivo Mayor , Trastornos por Estrés Postraumático , Inteligencia Artificial , Niño , Abuso Sexual Infantil/psicología , Depresión/diagnóstico , Trastorno Depresivo Mayor/diagnóstico , Femenino , Humanos , Masculino , Trastornos por Estrés Postraumático/diagnóstico , Trastornos por Estrés Postraumático/psicología
8.
Int J Clin Pract ; 75(11): e14880, 2021 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-34528350

RESUMEN

INTRODUCTION: Outbreaks of infectious diseases have negative effects on mental health. Currently, there is very little information about the psychological effects of the COVID-19 pandemic on adolescents and associated factors affecting their mental health. The aim of the present study is to determine the severity of anxiety, depression and post-traumatic stress disorder (PTSD) symptoms in adolescents during the COVID-19 outbreak, and to investigate the associated factors with these symptoms. METHODS: The present study was conducted with a total of 447 adolescents. Psychiatric symptoms were evaluated by the use of DSM-5 Level 2 Anxiety Scale, DSM-5 Level 2 Depression Scale and National Stressful Events Survey PTSD Short Scale. The association between age, gender, residential area, presence of COVID-19 in the participant, presence of COVID-19 in the family or environment and psychiatric symptoms were evaluated with linear regression analysis. RESULTS: The mean age of participants was 15.06, and 38.3% of the participants were men and 61.7% were women. The rate of participants with moderate or high levels of anxiety, depression and PTSD symptoms was 28%, 37.6% and 28.5%, respectively. High age and living in an urban area were associated with increased anxiety, depression and PTSD symptoms. In addition, female gender was associated with increased depression symptoms, and the presence of COVID-19 in the family or environment was associated with increased anxiety symptoms. CONCLUSION: The present study shows that adolescents have serious levels of anxiety, depression and PTSD symptoms during the COVID-19 pandemic. These results emphasise the need for mental health interventions that are appropriate for the characteristics of this age group.


Asunto(s)
COVID-19 , Trastornos por Estrés Postraumático , Adolescente , Ansiedad/epidemiología , Ansiedad/etiología , Estudios Transversales , Depresión/epidemiología , Depresión/etiología , Brotes de Enfermedades , Femenino , Humanos , Masculino , Pandemias , SARS-CoV-2 , Trastornos por Estrés Postraumático/epidemiología , Trastornos por Estrés Postraumático/etiología , Estrés Psicológico
9.
Nord J Psychiatry ; 73(2): 132-140, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30964388

RESUMEN

AIM: The aim of this study was to determine the prevalence of childhood psychopathologies in Turkey. METHOD: A nation-wide, randomly selected, representative population of 5830 children (6-13 years-old) enrolled as a 2nd,3rd or 4th grade student in 30 cities were evaluated for presence of a psychiatric or mental disorder by a Sociodemographic Form, Kiddie Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL), and DSM-IV-Based Screening Scale for Disruptive Behavior Disorders in Children and Adolescents scales. Impairment criterion was assessed via a 3 point-Likert scale by the parent and the teacher independently. RESULTS: Overall prevalence of any psychopathology was 37.6% without impairment criterion, and 17.1% with impairment criterion. Attention-deficit hyperactivity disorder was the most frequent diagnosis, followed by anxiety (19.5% and 16.7% without impairment, 12.4% and 5.3% with impairment, respectively). Lower education level and presence of a physical or psychiatric problem of the parents were independent predictors of any psychopathology of the offspring. CONCLUSION: This is the largest and most comprehensive epidemiological study to determine the prevalence of psychopathologies in children and adolescents in Turkey. Our results partly higher than, and partly comparable to previous national and international studies. It also contributes to the literature by determining the independent predictors of psychopathologies in this age group.


Asunto(s)
Trastornos del Neurodesarrollo/diagnóstico , Trastornos del Neurodesarrollo/epidemiología , Adolescente , Niño , Estudios Transversales , Manual Diagnóstico y Estadístico de los Trastornos Mentales , Femenino , Humanos , Masculino , Trastornos del Neurodesarrollo/psicología , Padres/psicología , Prevalencia , Psicopatología , Distribución Aleatoria , Estudiantes/psicología , Turquía/epidemiología
10.
Nord J Psychiatry ; 72(7): 501-505, 2018 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-30383476

RESUMEN

BACKGROUND AND AIM: Obsessive-compulsive disorder (OCD) is a common neuropsychiatric illness. Although the etiology of OCD is still unknown, recent investigations have associated development of OCD with infectious illness. Toxoplasma gondii (T. gondii) is a neurotropic protozoan parasite that causes infection of the central nervous system. In the last decade, a lot of researches have focused on the possible relationship between exposure to T. gondii and neuropsychiatric disorders such as schizophrenia. Therefore, in this study, it was aimed to investigate a possible association between Toxoplasma infection and OCD in children and adolescents. METHODS: We selected 55 patients with OCD (aged between 7 and 16 years) and 59 healthy children and adolescents (aged between 7 and 16 years), and investigated the seropositivity rate for anti-Toxoplasma IgG antibodies by enzyme-linked immunosorbent assay. RESULTS: The seropositivity rate for anti-T. gondii IgG antibodies among OCD patients (21.82%) was found to be higher than the rate in control group (15.25%). However, the difference between the OCD group and the control group was not statistically significant (p > .05). CONCLUSION: In contrast to studies in adult patients, the results of this study do not support the relationship between T. gondii and OCD children and adolescents.


Asunto(s)
Anticuerpos Antiprotozoarios/sangre , Trastorno Obsesivo Compulsivo/sangre , Trastorno Obsesivo Compulsivo/diagnóstico , Toxoplasma/metabolismo , Toxoplasmosis/sangre , Toxoplasmosis/diagnóstico , Adolescente , Anticuerpos Antiidiotipos/sangre , Niño , Estudios Transversales , Ensayo de Inmunoadsorción Enzimática , Femenino , Estudios de Seguimiento , Humanos , Masculino , Trastorno Obsesivo Compulsivo/psicología , Toxoplasma/aislamiento & purificación , Toxoplasmosis/psicología
11.
Child Psychiatry Hum Dev ; 48(2): 283-297, 2017 04.
Artículo en Inglés | MEDLINE | ID: mdl-27033363

RESUMEN

This study evaluates the associations among the symptoms of anxiety, depression, and disruptive behavioral disorders (DBD) in the context of their relationships with reactive-proactive aggression and anxiety sensitivity in children with attention-deficit/hyperactivity disorder (ADHD). The sample consisted of 342 treatment-naive children with ADHD. The severity of ADHD and DBD symptoms were assessed via parent- and teacher-rated inventories. Anxiety sensitivity, reactive-proactive aggression and severity of anxiety and depression symptoms of children were evaluated by self-report inventories. According to structural equation modeling, depression and anxiety scores had a relation with the DBD scores through reactive-proactive aggression. Results also showed a negative relation of the total scores of anxiety sensitivity on DBD scores, while conduct disorder scores had a positive relation with anxiety scores. This study suggests that examining the relations of reactive-proactive aggression and anxiety sensitivity with internalizing and externalizing disorders could be useful for understanding the link among these disorders in ADHD.


Asunto(s)
Agresión/psicología , Ansiedad/diagnóstico , Trastorno por Déficit de Atención con Hiperactividad , Depresión/diagnóstico , Problema de Conducta/psicología , Trastorno por Déficit de Atención con Hiperactividad/diagnóstico , Trastorno por Déficit de Atención con Hiperactividad/psicología , Niño , Mecanismos de Defensa , Femenino , Humanos , Masculino , Padres , Escalas de Valoración Psiquiátrica , Psicopatología , Proyectos de Investigación , Maestros , Autoinforme
12.
Compr Psychiatry ; 65: 15-23, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26773986

RESUMEN

BACKGROUND: Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS) is a promising scale for assessing frequency and severity of symptom dimensions. The main objective of the study was to assess the psychometric properties of the DY-BOCS in a large sample of children and adolescents from Turkey. METHODS: We studied 143 children and adolescents, 7-18years, with well characterized DSM-IV-R OCD, ascertained from seven collaborating university or state hospital sites. We compared the DY-BOCS scores with the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS), the Children's Depression Inventory (CDI), the Yale Global Tic Severity Scale (YGTSS) and the Child Behavior Checklist 6-18years (CBCL 6-18). RESULTS: The internal consistency of the DY-BOCS symptom dimensions and inter-rater agreement of component scores were excellent. The agreement between global DY-BOCS score and the total CY-BOCS score was highly significant (Pearson's r=0.55, p<0.0001). Severity scores for individual symptom dimensions were independent of one another, only modestly correlating with the global ratings, and were also differentially related to ratings of depression, anxiety and tic severity. CONCLUSION: The DY-BOCS is a reliable and valid instrument for assessing multiple aspects of OCD symptom severity in children and adolescents from Turkey.


Asunto(s)
Trastorno Obsesivo Compulsivo/psicología , Psicometría , Encuestas y Cuestionarios/normas , Adolescente , Ansiedad/psicología , Niño , Depresión/psicología , Femenino , Humanos , Masculino , Trastorno Obsesivo Compulsivo/diagnóstico , Reproducibilidad de los Resultados , Muestreo , Índice de Severidad de la Enfermedad , Turquía
13.
J Child Sex Abus ; 25(4): 415-27, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27266537

RESUMEN

The purpose of this study was to examine gender-based differences in abuse-related characteristics and post-abuse psychiatric disorders among sexually abused children and adolescents. The researchers retrospectively examined files, judicial reports, and social examination reports of 1,250 sexually abused youth cases. Results showed that boys were more often victimized by penetration, force, and physical violence. Incidence of sexual abuse by family members, familiar persons, and multiple persons was higher among girls. In addition, a higher rate of major depressive disorder as well as alcohol consumption and cigarette smoking were found in sexually abused girls. No difference was observed between boys and girls in terms of post-traumatic stress disorder, conduct disorder, and other mental disorders. Intellectual disability was more frequent in boys.


Asunto(s)
Abuso Sexual Infantil/estadística & datos numéricos , Trastornos Mentales/epidemiología , Adolescente , Niño , Abuso Sexual Infantil/legislación & jurisprudencia , Criminales/estadística & datos numéricos , Composición Familiar , Femenino , Humanos , Incidencia , Masculino , Trastornos Mentales/diagnóstico , Estudios Retrospectivos , Factores de Riesgo , Factores Sexuales , Trastornos por Estrés Postraumático/epidemiología , Turquía
14.
J Pediatr Gastroenterol Nutr ; 56(2): 211-4, 2013 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-22983377

RESUMEN

OBJECTIVE: Although it is well known that celiac disease (CD) is associated with neurologic disorders, association with psychiatric problems is not well defined. In this report, we aimed to detect CD prevalence in patients with attention-deficit hyperactivity disorder (ADHD). METHODS: A total of 362 patients between the ages 5 and 15 years with the diagnosis of ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) diagnostic criteria and 390 sex- and age-matched healthy children were included in the present study. Serum levels of tissue transglutaminase (tTg) immunoglobulin (Ig) A and IgG were studied in both groups. Serum IgA levels were also studied in patients with positive tTG IgG for the exclusion of selective IgA deficiency. Endoscopic duodenal biopsy was provided in seropositive patients, whose parents approved the procedure. Biopsy samples were evaluated according to Marsh-Oberhuber classification. RESULTS: tTg IgA was positive in 4 patients with ADHD (1.1%). Endoscopic duodenal biopsy was suggestive of CD in one of them (0.27%). tTg IgA was positive in 3 of control group patients (0.8%). Duodenal biopsy of the only patient from control group, who underwent upper gastrointestinal endoscopy, revealed normal intestinal mucosa. CONCLUSIONS: The seropositivity rates for CD were found similar in ADHD and control groups. Thus, neither routine screening for CD nor empirical recommendation of gluten-free diet seems necessary in children with ADHD.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/complicaciones , Enfermedad Celíaca/complicaciones , Duodeno/patología , Inmunoglobulina A/sangre , Inmunoglobulina G/sangre , Mucosa Intestinal/patología , Transglutaminasas/inmunología , Adolescente , Trastorno por Déficit de Atención con Hiperactividad/inmunología , Trastorno por Déficit de Atención con Hiperactividad/patología , Biopsia , Estudios de Casos y Controles , Enfermedad Celíaca/inmunología , Enfermedad Celíaca/patología , Niño , Endoscopía , Femenino , Humanos , Masculino , Prevalencia
15.
Eur Child Adolesc Psychiatry ; 22(9): 523-32, 2013 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-23460041

RESUMEN

Attention-deficit hyperactivity disorder (ADHD) is often comorbid with anxiety disorders and previous studies observed that anxiety could have an impact on the clinical course of ADHD and comorbid disruptive behavioral disorders (conduct disorders and oppositional-defiant disorders). Anxiety sensitivity (AS) is a different concept from anxiety per se and it is believed to represent the constitutionally based sensitivity of individuals to anxiety and anxiety symptoms. We aimed to assess the associations between anxiety, AS and symptoms of disruptive behavioral disorders (DBD) in a clinical sample of children and adolescents with ADHD. The sample consisted of 274 treatment naive children with ADHD aged 8-17 years. The severity of ADHD symptoms and comorbid DBD were assessed via parent rated Turgay DSM-IV-Based Child and Adolescent Behavioral Disorders Screening and Rating Scale (T-DSM-IV-S), Conners' Parent Rating Scale (CPRS), and Conners' Teacher Rating Scale (CTRS). AS and severity of anxiety symptoms of children were evaluated by self-report inventories. The association between anxiety, AS, and DBD was evaluated using structural equation modeling. Analyses revealed that AS social subscale scores negatively predicted symptoms of conduct disorder (CD) reported in T-DSM-IV-S. On the other hand, CD symptoms positively predicted severity of anxiety. No direct relationships were detected between anxiety, AS and oppositional-defiant behavior scores in any scales. These results may suggest a protective effect of AS social area on the development of conduct disorder in the presence of a diagnosis of ADHD, while the presence of symptoms of CD may be a vulnerability factor for the development of anxiety symptoms in children and adolescents with ADHD.


Asunto(s)
Trastornos de Ansiedad/diagnóstico , Ansiedad/diagnóstico , Trastorno por Déficit de Atención con Hiperactividad/diagnóstico , Trastorno de la Conducta/diagnóstico , Adolescente , Ansiedad/complicaciones , Ansiedad/psicología , Trastornos de Ansiedad/complicaciones , Trastornos de Ansiedad/psicología , Trastorno por Déficit de Atención con Hiperactividad/complicaciones , Trastorno por Déficit de Atención con Hiperactividad/psicología , Niño , Trastorno de la Conducta/complicaciones , Trastorno de la Conducta/psicología , Femenino , Humanos , Masculino , Autoinforme , Índice de Severidad de la Enfermedad
16.
Biomolecules ; 13(4)2023 03 28.
Artículo en Inglés | MEDLINE | ID: mdl-37189357

RESUMEN

Growth factors are a class of proteins that play a role in the proliferation (the increase in the number of cells resulting from cell division) and differentiation (when a cell undergoes changes in gene expression becoming a more specific type of cell) of cells. They can have both positive (accelerating the normal healing process) and negative effects (causing cancer) on disease progression and have potential applications in gene therapy and wound healing. However, their short half-life, low stability, and susceptibility to degradation by enzymes at body temperature make them easily degradable in vivo. To improve their effectiveness and stability, growth factors require carriers for delivery that protect them from heat, pH changes, and proteolysis. These carriers should also be able to deliver the growth factors to their intended destination. This review focuses on the current scientific literature concerning the physicochemical properties (such as biocompatibility, high affinity for binding growth factors, improved bioactivity and stability of the growth factors, protection from heat, pH changes or appropriate electric charge for growth factor attachment via electrostatic interactions) of macroions, growth factors, and macroion-growth factor assemblies, as well as their potential uses in medicine (e.g., diabetic wound healing, tissue regeneration, and cancer therapy). Specific attention is given to three types of growth factors: vascular endothelial growth factors, human fibroblast growth factors, and neurotrophins, as well as selected biocompatible synthetic macroions (obtained through standard polymerization techniques) and polysaccharides (natural macroions composed of repeating monomeric units of monosaccharides). Understanding the mechanisms by which growth factors bind to potential carriers could lead to more effective delivery methods for these proteins, which are of significant interest in the diagnosis and treatment of neurodegenerative and civilization diseases, as well as in the healing of chronic wounds.


Asunto(s)
Péptidos y Proteínas de Señalización Intercelular , Cicatrización de Heridas , Humanos
17.
Colloids Surf B Biointerfaces ; 226: 113301, 2023 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-37075524

RESUMEN

Outer membrane lipopolysaccharides (LPS) play a crucial role in determining attachment behavior and pathogenicity of bacteria. The aim of this study was to develop a simple procedure for anchoring bacterial lipopolysaccharides to polystyrene (PS) microparticles as a model system for in situ attachment studies. By using a swell-capture methodology, commercially available LPS of Pseudomonas aeruginosa (strain ATCC 27316 serotype 10.22) was anchored onto PS microparticles in a proof-of-concept study. A detailed chemical and morphological characterization has proven the success of LPS incorporation. It was shown that the coverage and structure of the LPS film was concentration dependent. The procedure can easily be adapted to LPS of other bacterial strains to generate a synthetic model toolkit for attachment studies.


Asunto(s)
Lipopolisacáridos , Poliestirenos , Lipopolisacáridos/metabolismo , Poliestirenos/metabolismo , Virulencia , Pseudomonas aeruginosa/metabolismo
18.
Alpha Psychiatry ; 24(5): 211-216, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38105778

RESUMEN

Objective: The aim of this study was to determine the vestibular function of children diagnosed with specific learning disorders (SLD). Methods: This study was conducted with 30 children diagnosed with SLD and 30 healthy children matched for age and sex, and vestibular tests were applied. Results: Optokinetic and head shake test values in videonystagmography subtests were found to be pathological in the study group, and the lateral asymmetry value in video head impulse test (v-HIT) was found to be significantly higher in the study group. Also, a significant difference was found in the N1 latency, P1-N1 interlatency, P1-N1 amplitude values in the cervical vestibular evoked myogenic potential test, and asymmetry values in the ocular vestibular evoked myogenic potential test. Conclusion: The current study showed that vestibular functions may differ from normal in SLD patients and that vestibular dysfunction may play a role in symptoms such as postural instability, balance, and gross and fine motor disorders that are frequently observed in these children.

19.
Emerg Med J ; 29(11): 911-4, 2012 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22215173

RESUMEN

INTRODUCTION: Trauma is one of the leading reasons for emergency department (ED) visits in children. Hyperactivity, inattentiveness and impulsiveness may contribute to injury proneness. The aim of this study was to evaluate the prevalence and role of attention deficit hyperactivity disorder (ADHD) in children with trauma. METHODS: Trauma patients aged 3-17 attending the ED were included in the study group. Parents were informed after medical care had been given to their children, and demographic data and information about the trauma were collected. Later, parents were asked to complete the Conners' Parent Rating Scales-Revised questionnaire for ADHD symptoms. The control group consisted of children of similar age and sociocultural characteristics who attended the hospital for reasons other than trauma. Cases in which the child apparently had no active role in the trauma or where the parents did not complete the Conners' Parent Rating Scales-Revised questionnaire were excluded from the study. RESULTS: Fifty-five children were included in the study group (mean age 7.49 (range 3-14; SD 3.3); 33 (60%) were male). The control group was statistically similar to the study group. The most common trauma mechanism was falls (n=31, 56.4%). All the subscale scores were significantly higher in the study group, and previous trauma-related ED visits were associated with significantly higher subscale scores. CONCLUSION: The data suggest that children who make repeated trauma-related ED visits have a predisposition to ADHD, and they may benefit from screening for this disorder while in the ED.


Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/epidemiología , Servicio de Urgencia en Hospital/estadística & datos numéricos , Heridas y Lesiones/epidemiología , Adolescente , Estudios de Casos y Controles , Niño , Preescolar , Femenino , Humanos , Incidencia , Masculino , Estudios Prospectivos , Turquía/epidemiología , Heridas y Lesiones/etiología
20.
Ulus Travma Acil Cerrahi Derg ; 18(2): 118-24, 2012 Mar.
Artículo en Turco | MEDLINE | ID: mdl-22792817

RESUMEN

BACKGROUND: We aimed to investigate the clinical aspects and visual prognosis in eye injury and to constitute data in the west Black Sea region in Turkey for national statistics. METHODS: A retrospective analysis of 281 eye trauma cases admitted to the Emergency Department of Zonguldak Karaelmas University Hospital between 2005 and 2010 was performed. RESULTS: A majority of eye injuries (42.7%) affected individuals aged 30 to 50 years. The most frequent cause of injury in the rural areas was wooden objects. The most frequent cause of injury in males aged 30 to 50 years was work-site injuries. Corneal-scleral lacerations were found to be the most serious injuries with regard to initial and final visual acuities. CONCLUSION: Eye injuries are still the most common and preventable cause of blindness. Simple precautions and public education might prevent this health problem, which causes economic and labor force loss and psychological problems. One of the basic precautions would be raising public awareness on wearing a seat belt inside the car and protective eyeglasses at the work site and while working in rural areas.


Asunto(s)
Lesiones Oculares/epidemiología , Traumatismos Ocupacionales/epidemiología , Adolescente , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Lesiones Oculares/etiología , Lesiones Oculares/prevención & control , Dispositivos de Protección de los Ojos , Femenino , Humanos , Lactante , Masculino , Persona de Mediana Edad , Traumatismos Ocupacionales/prevención & control , Pronóstico , Estudios Retrospectivos , Factores Sexuales , Turquía/epidemiología , Adulto Joven
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