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1.

Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation.

Duke-Cohan, Jonathan S; Akitsu, Aoi; Mallis, Robert J; Messier, Cameron M; Lizotte, Patrick H; Aster, Jon C; Hwang, Wonmuk; Lang, Matthew J; Reinherz, Ellis L.

Nature ; 613(7944): 565-574, 2023 01.

Artículo en Inglés | MEDLINE | ID: mdl-36410718

2.

T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.

Martin, Bradley N; Wang, Chenhui; Zhang, Cun-jin; Kang, Zizhen; Gulen, Muhammet Fatih; Zepp, Jarod A; Zhao, Junjie; Bian, Guanglin; Do, Jeong-su; Min, Booki; Pavicic, Paul G; El-Sanadi, Caroline; Fox, Paul L; Akitsu, Aoi; Iwakura, Yoichiro; Sarkar, Anasuya; Wewers, Mark D; Kaiser, William J; Mocarski, Edward S; Rothenberg, Marc E; Hise, Amy G; Dubyak, George R; Ransohoff, Richard M; Li, Xiaoxia.

Nat Immunol ; 17(5): 583-92, 2016 May.

Artículo en Inglés | MEDLINE | ID: mdl-26998763

3.

Molecular design of the Î³Î´T cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing.

Mallis, Robert J; Duke-Cohan, Jonathan S; Das, Dibyendu Kumar; Akitsu, Aoi; Luoma, Adrienne M; Banik, Debasis; Stephens, Hannah M; Tetteh, Paul W; Castro, Caitlin D; Krahnke, Sophie; Hussey, Rebecca E; Lawney, Brian; Brazin, Kristine N; Reche, Pedro A; Hwang, Wonmuk; Adams, Erin J; Lang, Matthew J; Reinherz, Ellis L.

Proc Natl Acad Sci U S A ; 118(26)2021 06 29.

Artículo en Inglés | MEDLINE | ID: mdl-34172580

4.

Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans.

Saijo, Shinobu; Ikeda, Satoshi; Yamabe, Keiko; Kakuta, Shigeru; Ishigame, Harumichi; Akitsu, Aoi; Fujikado, Noriyuki; Kusaka, Toshimasa; Kubo, Sachiko; Chung, Soo-hyun; Komatsu, Ryohei; Miura, Noriko; Adachi, Yoshiyuki; Ohno, Naohito; Shibuya, Kazutoshi; Yamamoto, Natsuo; Kawakami, Kazuyoshi; Yamasaki, Sho; Saito, Takashi; Akira, Shizuo; Iwakura, Yoichiro.

Immunity ; 32(5): 681-91, 2010 May 28.

Artículo en Inglés | MEDLINE | ID: mdl-20493731

5.

Interleukin-17-producing Î³Î´ T (Î³Î´17) cells in inflammatory diseases.

Akitsu, Aoi; Iwakura, Yoichiro.

Immunology ; 155(4): 418-426, 2018 12.

Artículo en Inglés | MEDLINE | ID: mdl-30133701

6.

Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.

Ishigame, Harumichi; Kakuta, Shigeru; Nagai, Takeshi; Kadoki, Motohiko; Nambu, Aya; Komiyama, Yutaka; Fujikado, Noriyuki; Tanahashi, Yuko; Akitsu, Aoi; Kotaki, Hayato; Sudo, Katsuko; Nakae, Susumu; Sasakawa, Chihiro; Iwakura, Yoichiro.

Immunity ; 30(1): 108-19, 2009 Jan 16.

Artículo en Inglés | MEDLINE | ID: mdl-19144317

7.

Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-ß-induced Foxp3 expression.

Ikeda, Satoshi; Saijo, Shinobu; Murayama, Masanori A; Shimizu, Kenji; Akitsu, Aoi; Iwakura, Yoichiro.

J Immunol ; 192(4): 1449-58, 2014 Feb 15.

Artículo en Inglés | MEDLINE | ID: mdl-24431229

8.

Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock.

Shimura, Eri; Shibui, Akiko; Narushima, Seiko; Nambu, Aya; Yamaguchi, Sachiko; Akitsu, Aoi; Leonard, Warren J; Iwakura, Yoichiro; Matsumoto, Kenji; Suto, Hajime; Okumura, Ko; Sudo, Katsuko; Nakae, Susumu.

Biochem Biophys Res Commun ; 453(1): 1-6, 2014 Oct 10.

Artículo en Inglés | MEDLINE | ID: mdl-25204502

9.

Parsing digital or analogue TCR performance through piconewton forces.

Akitsu, Aoi; Kobayashi, Eiji; Feng, Yinnian; Stephens, Hannah M; Brazin, Kristine N; Masi, Daniel J; Kirpatrick, Evan H; Mallis, Robert J; Duke-Cohan, Jonathan S; Booker, Matthew A; Cinella, Vincenzo; Feng, William W; Holliday, Elizabeth L; Lee, Jonathan J; Zienkiewicz, Katarzyna J; Tolstorukov, Michael Y; Hwang, Wonmuk; Lang, Matthew J; Reinherz, Ellis L.

bioRxiv ; 2023 Nov 30.

Artículo en Inglés | MEDLINE | ID: mdl-38076892

10.

The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17.

Makusheva, Yulia; Chung, Soo-Hyun; Akitsu, Aoi; Maeda, Natsumi; Maruhashi, Takumi; Ye, Xiao-Qi; Kaifu, Tomonori; Saijo, Shinobu; Sun, Haiyang; Han, Wei; Tang, Ce; Iwakura, Yoichiro.

Exp Anim ; 71(3): 288-304, 2022 Aug 05.

Artículo en Inglés | MEDLINE | ID: mdl-35135958

11.

Protein disulfide isomerase-P5, down-regulated in the final stage of boar epididymal sperm maturation, catalyzes disulfide formation to inhibit protein function in oxidative refolding of reduced denatured lysozyme.

Akama, Kuniko; Horikoshi, Tomoe; Sugiyama, Atsushi; Nakahata, Satoko; Akitsu, Aoi; Niwa, Nobuyoshi; Intoh, Atsushi; Kakui, Yasutaka; Sugaya, Michiko; Takei, Kazuo; Imaizumi, Noriaki; Sato, Takaya; Matsumoto, Rena; Iwahashi, Hitoshi; Kashiwabara, Shin-ichi; Baba, Tadashi; Nakamura, Megumi; Toda, Tosifusa.

Biochim Biophys Acta ; 1804(6): 1272-84, 2010 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-20152940

12.

Pre-T cell receptors topologically sample self-ligands during thymocyte ß-selection.

Li, Xiaolong; Mizsei, Réka; Tan, Kemin; Mallis, Robert J; Duke-Cohan, Jonathan S; Akitsu, Aoi; Tetteh, Paul W; Dubey, Abhinav; Hwang, Wonmuk; Wagner, Gerhard; Lang, Matthew J; Arthanari, Haribabu; Wang, Jia-Huai; Reinherz, Ellis L.

Science ; 371(6525): 181-185, 2021 01 08.

Artículo en Inglés | MEDLINE | ID: mdl-33335016

13.

Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity.

Mahadevan, Navin R; Knelson, Erik H; Wolff, Jacquelyn O; Vajdi, Amir; Saigí, Maria; Campisi, Marco; Hong, Deli; Thai, Tran C; Piel, Brandon; Han, Saemi; Reinhold, Bruce B; Duke-Cohan, Jonathan S; Poitras, Michael J; Taus, Luke J; Lizotte, Patrick H; Portell, Andrew; Quadros, Victor; Santucci, Alison D; Murayama, Takahiko; Cañadas, Israel; Kitajima, Shunsuke; Akitsu, Aoi; Fridrikh, Maya; Watanabe, Hideo; Reardon, Brendan; Gokhale, Prafulla C; Paweletz, Cloud P; Awad, Mark M; Van Allen, Eliezer M; Lako, Ana; Wang, Xi-Tao; Chen, Benjamin; Hong, Fangxin; Sholl, Lynette M; Tolstorukov, Michael Y; Pfaff, Kathleen; Jänne, Pasi A; Gjini, Evisa; Edwards, Robin; Rodig, Scott; Reinherz, Ellis L; Oser, Matthew G; Barbie, David A.

Cancer Discov ; 11(8): 1952-1969, 2021 08.

Artículo en Inglés | MEDLINE | ID: mdl-33707236

14.

[IL-17 family and receptor pathway].

Akitsu, Aoi; Iwakura, Yoichiro.

Nihon Rinsho ; 70 Suppl 8: 207-11, 2012 Nov.

Artículo en Japonés | MEDLINE | ID: mdl-23513838

15.

IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)VÎ³6(+)Î³Î´ T cells.

Akitsu, Aoi; Ishigame, Harumichi; Kakuta, Shigeru; Chung, Soo-Hyun; Ikeda, Satoshi; Shimizu, Kenji; Kubo, Sachiko; Liu, Yang; Umemura, Masayuki; Matsuzaki, Goro; Yoshikai, Yasunobu; Saijo, Shinobu; Iwakura, Yoichiro.

Nat Commun ; 6: 7464, 2015 Jun 25.

Artículo en Inglés | MEDLINE | ID: mdl-26108163

16.

Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis.

Akitsu, Aoi; Kakuta, Shigeru; Saijo, Shinobu; Iwakura, Yoichiro.

Exp Anim ; 63(2): 235-46, 2014.

Artículo en Inglés | MEDLINE | ID: mdl-24770649

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