Parent knowledge regarding food selection for children with PKU: Results of a survey in the United States.

OBJECTIVES: Dietary treatment is the main therapy for most patients with phenylketonuria (PKU). Parental knowledge regarding food selection is crucial to ensure adequate metabolic control and brain development during childhood and to promote lifelong adherence and healthy dietary behavior in the offspring. The aims of this study were to assess whether parental or caregiver knowledge regarding nutritional selection for children with PKU is in accordance with medical recommendations and to evaluate factors that influence their level of knowledge. METHODS: This was a cross-sectional observational study. An online or paper survey (N = 178) was distributed throughout the United States. The survey included a validated food selection questionnaire to assess whether the respondent adequately identified foods that require certain restrictions versus foods that can be consumed freely by an individual with PKU. RESULTS: General knowledge of food selection among the caregivers was very high or high in nearly 60% (60-98th score percentile). Participants with the lowest scores in general knowledge of the PKU diet (quartile 1) were more likely to label allowed foods incorrectly. Respondents with the highest scores (quartile 4) were more likely to label limited foods correctly but incorrectly label allowed items. CONCLUSION: Knowledge of restricted foods is important to avoid poor metabolic control, but knowledge of allowed foods can be just as important to allow for a diet that is diverse, palatable, and nutritionally balanced.

Development and Validation of SERR Scale for Detecting Extremism and Religious Radicalism.

BACKGROUND: In line with the growing religious, political and social violence around the world, this study evaluates the psychometric properties of a new scale for Detecting Extremism and Religious Radicalism (SERR), a self-report measure of extremism and religious radicalism. METHOD: Factor analyses, validity and reliability data were collected using a sample of 1985 participants from 58 different cities around Spain who self-identified as actively practicing their religion. RESULTS: Statistical analyses of SERR scores yielded acceptable internal consistency scores (ω > .74) and confirmed key factors associated with radicalism and extremism. The structure of the scale was confirmed as two-dimensional (χ2(64) = 361.22, p < .001, CFI = 0.976, TLI = 0.970, RMSEA (90% CI) = 0.089 (0.080 - 0.098), SRMR = 0.064). Scores for the extremism dimension correlated significantly and positively with scores for the same factor on the Activism and Radicalism Intention Scales (r = .32, p < .001, n = 139). CONCLUSIONS: The SERR demonstrates adequate reliability and validity for evaluating the degree of extremism and radicalism in Christian/Catholic and Muslim believers.

Adaptation and Validation of a Questionnaire to Evaluate Knowledge of the Low Phe Diet in PKU.

Phenylketonuria (PKU) is an autosomal recessive disorder of phenylalanine (Phe) metabolism, causing a build-up of Phe in the body. Treatment consists of a Phe-restricted diet for life and regular determination of blood Phe levels to monitor the intake of Phe. Despite the fact that diet is the cornerstone of treatment, there are no studies examining common knowledge about food items and whether they are allowed as part of the PKU diet. Improving parents' and patients' knowledge and competence about the diet enables them to make appropriate food choices. This study validates a food-knowledge questionnaire first developed in Spanish and modified for English speaking populations. The questionnaire potentially helps parents to prepare appropriate meals and healthcare providers to create individualized educational programs about PKU for children and adolescents with this disorder.

Dasatinib and FLAG-IDA Is an Effective Therapy for Initial Myeloid Blast Crisis but Involves a High Risk of Opportunistic Infections.

Blast crisis (BC) continues to be the major challenge in the treatment of chronic myeloid leukemia. Best results have been observed in a few patients who were successfully transplanted after returning to chronic phase. Recent studies focus on the combination of chemotherapy with imatinib, but results remain unsatisfactory. Since dasatinib induces deeper and faster responses, a reasonable strategy might be to combine it with chemotherapy, taking into account the alterations in T-cell response induced by dasatinib. However, there are no published studies or case reports supporting the use of dasatinib as first line treatment for initial myeloid BC, and very little is known about infectious complications associated with this drug. Based on this, we present the case of a patient diagnosed with an initial nonlymphoid phenotype BC, who achieved molecular response (MR4.5) with dasatinib and FLAG-IDA, but he suffered a pulmonary aspergillosis, CMV infection, and a CMV reactivation, prior to an allogeneic hematopoietic stem cell transplantation (HSCT). In conclusion, dasatinib and FLAG-IDA is an effective therapy for initial BC. However, a warning call is needed owing to the high risk of opportunistic infections, such as CMV.

Development and Validation of SERR Scale for Detecting Extremism and Religious Radicalism / Desarrollo y Validación de la Escala SERR para la Detección del Extremismo y Radicalismo Religioso

Background: In liiine with the growing religious, political and social violence around the world, this study evaluates the psychometric properties of a new scale for Detecting Extremism and Religious Radicalism (SERR), a self-report measure of extremism and religious radicalism. Method: Factor analyses, validity and reliability data were collected using a sample of 1985 participants from 58 different cities around Spain who self-identified as actively practicing their religion. Results: Statistical analyses of SERR scores yielded acceptable internal consistency scores (ω > .74) and confirmed key factors associated with radicalism and extremism. The structure of the scale was confirmed as two dimensional (χ²(64) = 361.22, p < .001, CFI = 0.976, TLI = 0.970, RMSEA (90% CI) = 0.089 (0.080 - 0.098), SRMR = 0.064). Scores for the extremism dimension correlated significantly and positively with scores for the same factor on the Activism and Radicalism Intention Scales (r = .32, p < .001, n = 139). Conclusions: The SERR demonstrates adequate reliability and validity for evaluating the degree of extremism and radicalism in Christian/Catholic and Muslim believers.(AU)

Antecedentes: en consonancia con la creciente violencia religiosa, política y social en todo el mundo, este estudio evalúa las propiedades psicométricas de la escala para la detección del extremismo y el radicalismo religioso (SERR), una medida de autoinforme del extremismo y el radicalismo religioso. Método: los análisis factoriales y las evidencias de validez y fiabilidad se recopilaron utilizando una muestra de 1985 participantes de 58 ciudades distintas de España que se identificaron a sí mismos como practicantes activos de su religión. Resultados: los análisis estadísticos de las puntuaciones SERR arrojaron puntuaciones de consistencia interna aceptables (ω > .74) y confirmaron los factores clave asociados con el radicalismo y el extremismo. La estructura de la escala se confirmó como bidimensional (χ²(64) = 361.22, p < .001, CFI = 0.976, TLI = 0.970, RMSEA (90% CI) = 0.089 (0.080 - 0.098), SRMR = 0.064). Las puntuaciones de la dimensión de extremismo se correlacionaron significativa y positivamente con las puntuaciones del mismo factor en la Escala de Intención de Activismo y Radicalismo (r = 0,32, p < 0.001, n = 139). Conclusiones: los autores concluyen que el SERR muestra una fiabilidad y validez adecuadas para evaluar el grado de extremismo y radicalismo en creyentes cristianos/católicos y musulmanes.(AU)

Caracterización epidemiológica, clínica e histopatológica de los tumores malignos de cérvix en las pacientes sometidas a histerectomía radical tipo Wertheim-Meigs que acuden al servicio de Ginecología y Obstetricia del Hospital General San Juan de Dios, de Guatemala (enero 2017 a diciembre del 2018) / Epidemiological, clinical and histopathological characterization of malignant tumors of the cervix in patients undergoing Wertheim-Meigs radical hysterectomy who attend the Gynecology and Obstetrics service of the San Juan de Dios General Hospital, Guatemala (January 2017 to December 2018)

Los tumores malignos de cérvix continúan siendo un problema de salud pública para nuestro país, es por ello que se consideró de importancia realizar este estudio. Se estudiaron las características clínicas más frecuentes encontradas en las pacientes sometidas dentro de los cuales encontramos como principal motivo de consulta el dolor pélvico con un 86.75%, seguido del sangrado con un 84.34% finalizando con la leucorrea con el 79.52%. En cuanto a la clasificación de los tumores malignos se comprobó que la mayoría de las pacientes presentaron el estadio CaCu IB1 con el 91.57% seguido del CaCu IA1 con el 6.02% finalizando con el CaCu IB2 con el 2.41%. Así mismo, se pudo determinar que los tumores malignos de cérvix más frecuentes en las pacientes estudiadas fue el carcinoma epitelial, seguido del adenocarcinoma de cérvix, siendo su histopatología más encontrada el carcinoma epidermoide no queratinizante de células grandes con el 53.01%. (AU)

Uterine Cervical Cancer continues to be one of the main public health problems in Guatemala, thus being important to do this type of research. The most frequent clinical characteristics found in the present study were pelvic pain (86.75%) followed by bleeding in 84.34% and vaginal discharge in 79.52%. Most of the patients were classified as Stage IB1 (91.57%) followed by Stage IA1(6/02%) and Stage IB2 (2.41%). The most frequent Histologic Type was Squamous Carcinoma. (AU)

Blastic plasmacytoid dendritic cell neoplasm frequently shows occult central nervous system involvement at diagnosis and benefits from intrathecal therapy.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive myeloid neoplasm which shows a high rate of central nervous system (CNS) recurrence and overall survival (OS) of <1 year. Despite this, screening for CNS involvement is not routinely performed at diagnosis and intrathecal (IT) prophylaxis is not regularly administered in BPDCN. Here, we prospectively evaluated 13 consecutive BPDCN patients for the presence of CNS involvement by flow cytometry. Despite none of the patients presented with neurological symptoms, occult CNS involvement was detected in 6/10 cases evaluated at diagnosis and 3/3 studied at relapse/progression. BPDCN patients evaluated at diagnosis received IT treatment -either CNS prophylaxis (n = 4) or active therapy (n = 6)- and all but one remain alive (median follow-up of 20 months). In contrast, all three patients assessed at relapse/progression died. The potential benefit of IT treatment administered early at diagnosis on OS and CNS recurrence-free survival of BPDCN was further confirmed in a retrospective cohort of another 23 BPDCN patients. Our results show that BPDCN patients studied at diagnosis frequently display occult CNS involvement; moreover, they also indicate that treatment of occult CNS disease might lead to a dramatically improved outcome of BPDCN.

Factores que influyen en la duración de la lactancia materna en las estudiantes universitarias / Factors that influence the duration of breastfeeding in university students / Fatores que influenciam a duração da amamentação em estudantes universitarios

Resumen 19) Las estudiantes universitarias que amamantan enfrentan retos en relación con el complimiento de diferentes roles, motivo por el que este estudio trató de determinar los factores que influyen en la duración de la lactancia materna en esta población. Este artículo corresponde a una investigación cualitativa de tipo descriptivo, con una población de diez estudiantes universitarias que amamantaban a sus hijos e hijas. Para la recolección de datos se utilizó la entrevista semiestructurada y el análisis se realizó triangulando los datos obtenidos, la teoría de I. King y los aportes de los investigadores. Los resultados señalaron que las estudiantes universitarias perciben que la lactancia materna es un derecho, un beneficio, y el mejor alimento que pueden brindarle a sus hijos e hijas. La familia o amigos generalmente son los que plantean la idea de abandonar la lactancia materna, además el entorno familiar influye directamente en la duración de la lactancia materna. Se concluye que el éxito en la lactancia de las estudiantes universitarias madres va estar influenciado por diferentes factores tantos personales, interpersonales y sociales que son dinámicos y que se relacionan entre sí, además de las redes de apoyo, educación en salud, acompañamiento y la acciones en pro de la lactancia materna de la institución universitaria y de sus propios entornos familiares.

Abstract 23) The breastfeeding university students face challenges concerning the fulfillment of different roles, this is how this study tried to determine which factors influence the duration of breastfeeding in this population. This article corresponds to descriptive qualitative research, with a population of ten university students who breast-fed their sons and daughters. For data collection, the semi-structured interview was used and triangulating the data obtained, the theory of I. King and the contributions of the researchers. The results indicated that university students perceive that breastfeeding is a right, a benefit, and the best food they can provide to their children. The family or friends are usually those who raise the idea of abandoning breastfeeding, also, the family environment directly influences the duration of breastfeeding. It is concluded that the success in breastfeeding of university students mothers will be influenced by different personal, interpersonal and social factors that are dynamic and related to each other, besides, to support networks, health education, accompaniment and actions in favor of breastfeeding the university institution and their family environments.

Resumo 27) Os estudantes universitários que amamentam enfrentam desafios em relação à realização de diferentes papéis, assim como este estudo procurou determinar quais fatores influenciam a duração do aleitamento materno nessa população. Corresponde a uma pesquisa qualitativa, do tipo descritiva, contou-se com uma população de dez universitários que amamentavam seus filhos e filhas. Para coleta de dados, utilizou-se a entrevista semiestruturada e a análise foi realizada com base na triangulação dos dados obtidos, a teoria de I. King e as contribuições dos pesquisadores. Os universitários percebem que o aleitamento materno é um direito, um benefício e a melhor alimentação que podem proporcionar aos seus filhos. Família ou amigos são geralmente aqueles que levantam a ideia de abandonar a amamentação, além do ambiente familiar influenciar diretamente a duração da amamentação. Conclui-se que o sucesso da amamentação de mulheres universitárias será influenciado por diferentes fatores pessoais, interpessoais e sociais, dinâmicos e relacionados entre si, além de redes de apoio, educação em saúde, acompanhamento e ações em prol da maternidade. do aleitamento materno da instituição universitária e do próprio ambiente familiar.

Fracaso renal agudo en pacientes con mieloma: Nuestra experiencia con hemodiálisis extendidas con dializadores de alto poro / Acute renal failure in patients with myeloma: Experience with extended high cut-off hemodialysis

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Caracterización del uso de los medios de enseñanza por los profesores que se desempeñan en el Nuevo Programa de Formación de Médicos / Characterization of the use of the teaching aids by the professors involved in the New Program of Medical Training

Se realizó la identificación de las principales insuficiencias en la utilización de los medios de enseñanza por los médicos que actúan como profesores en el Nuevo Programa de Formación de Médicos, en el polo de la Isla de Juventud, durante el curso 2006-2007. Se diseñó una encuesta y 2 guías de observación. La encuesta fue dirigida a 77 profesores, con el propósito de indagar sobre su superación en la utilización de los medios de enseñanza y la autoevaluación de su desempeño en el uso de los mismos, y fue autoadministrada por los profesores. Una guía de observación para valorar el uso de los medios de enseñanza durante la actividad de orientación de contenido aplicada a un total de 18 profesores y una guía para valorar la calidad de las presentaciones digitales, se realizó a 16 presentaciones elaboradas por los profesores, seleccionadas al azar. Las principales dificultades identificadas fueron en el uso de los medios de enseñanza, el manejo del pizarrón, la elaboración de las presentaciones digitales en power point y en la utilización de multimedia.

The main shortages in the use of the teaching aids by the physicians working as professors in the New Program of Medical Training in the Isle of Youth during the course 2006-2007 were identified. A survey and two guides of observation were designed. The survey was directed to 77 professors to know about their upgrading in the utilization of the teaching aids, and the self-assessment of their performance in their use. The survey was self-administered by the professors. A guide of observation to evaluate the use of the teaching aids during the content orientation activity was done among 18 professors, whereas another guide to assess the quality of the digital presentations was applied to 16 randomized presentations designed by the professors. The main difficulties found were the use of the teaching aids, the utilization of the blackboard, the making of digital presentations in power point, and the use of multimedia.

Caracterización del uso de los medios de enseñanza por los profesores que se desempeñan en el Nuevo Programa de Formación de Médicos / Characterization of the use of the teaching aids by the professors involved in the New Program of Medical Training

Se realizó la identificación de las principales insuficiencias en la utilización de los medios de enseñanza por los médicos que actúan como profesores en el Nuevo Programa de Formación de Médicos, en el polo de la Isla de Juventud, durante el curso 2006-2007. Se diseñó una encuesta y 2 guías de observación. La encuesta fue dirigida a 77 profesores, con el propósito de indagar sobre su superación en la utilización de los medios de enseñanza y la autoevaluación de su desempeño en el uso de los mismos, y fue autoadministrada por los profesores. Una guía de observación para valorar el uso de los medios de enseñanza durante la actividad de orientación de contenido aplicada a un total de 18 profesores y una guía para valorar la calidad de las presentaciones digitales, se realizó a 16 presentaciones elaboradas por los profesores, seleccionadas al azar. Las principales dificultades identificadas fueron en el uso de los medios de enseñanza, el manejo del pizarrón, la elaboración de las presentaciones digitales en power point y en la utilización de multimedia(AU)

The main shortages in the use of the teaching aids by the physicians working as professors in the New Program of Medical Training in the Isle of Youth during the course 2006-2007 were identified. A survey and two guides of observation were designed. The survey was directed to 77 professors to know about their upgrading in the utilization of the teaching aids, and the self-assessment of their performance in their use. The survey was self-administered by the professors. A guide of observation to evaluate the use of the teaching aids during the content orientation activity was done among 18 professors, whereas another guide to assess the quality of the digital presentations was applied to 16 randomized presentations designed by the professors. The main difficulties found were the use of the teaching aids, the utilization of the blackboard, the making of digital presentations in power point, and the use of multimedia(AU)

Utilización de la batería neuropsicológica Halstead-Reitan en un servicio de psiquiatría / Application of the Halstead-Reitan neuropsychological tests batery in a psychiatric service

Se presentan los resultados de la aplicación de la Bactería Neuropsicológica de Halstead-Reitan (BNHR) en el Servicio de Psiquiatría del Hospital Guillermo Grant Benavente de Concepción. El instrumento, en su mayoría fue aplicado por estudiantes de Psicología entrenados a una muestra de 50 pacientes y familiares. Los resultados indican que el puntaje de corte para la obtención de índice de deterioro considerando toda la muestra se ubica en el rango de 0.70 y 0.80 con una sencibilidad de 52.4 por ciento y especificidad de 51.7 por ciento. Estos índices no fueron lo esperados, sin embargo, se rescatan elementos de la prueba que son más útiles y sugieren nuevos estudios, ya que se aprecia que el instrumento puede ser una buena alternativa diagnóstica

Guía de operación y mantenimiento para establecimientos de salud de primer nivel de atención: ingenieria en mantenimiento hospitalario de infraestructura y equipamiento / Guide of operation and maintenance for health facilities of first level of care: engineering in maintenance hospital of infrastructure and equipment

La guía de mantenimiento se dividió en las siguientes especialidades de mantenimiento: equipo electromédico, de equipos de apoyo, arquitectura, instalaciones especiales y áreas exteriores. Además se le incorporó los temas de saneamiento, seguridad y primeros auxilios

Guia de equipamiento y mantenimiento para establecimientos de salud del primer nivel de atención: informe final de consultoría / sss

Esta guía permite mecanismos de intervención y programación para la solución de las deficiencias en la calidad de atención secundarias al uso inadecuado del recurso físico, contribuyendo de esta manera al mejoramiento del nivel de vida y salud del paciente y la población, en el marco de la gestión compartida con participación popular determinada por el Decreto Supremo 24237 del Sistema Público Descentralizado y Participativo de Salud

Ingenieria en mantenimiento hospitalario de infraestructura y equipamiento: Guia de operacion y mantenimiento para establecimientos de salud de Primer Nivel de Atencion / s

Descripcion del programa. Administracion de actividades. Planificacion de mantenimiento. Supervision y control tecnico de la actividad de mantenimiento. Seguridad