Sero-prevalence of hepatitis B virus markers and associated factors among children in Hawassa City, southern Ethiopia.

BACKGROUND: Hepatitis B virus (HBV) infection is one of the major public health problems worldwide. Limited information exists about the epidemiology of HBV infection in Ethiopia. This study aimed to assess sero-prevalence of HBV markers and associated factors in children living in Hawassa City, southern Ethiopia. METHODS: A community-based cross-sectional study was conducted among 471 children in Hawassa City, southern Ethiopia from May to September, 2018. A total of 471 children were included in the study using a multistage sampling technique. Data on demographic and risk factors were gathered using structured questionnaires. Blood samples were collected and sera were screened for hepatitis B surface antigen (HBsAg), antibody to core antigen (anti-HBc), and antibody against surface antigen (anti-HBs) using enzyme-linked immunosorbent assay. RESULTS: The sero-prevalence of HBsAg, anti-HBc, and anti-HBs markers among children were 4.4, 19.5 and 20.0%, respectively. Children at higher risk of having HBsAg marker were those who had a history of injectable medications (AOR 5.02, 95% CI: 1.14, 22.07), a family history of liver disease (AOR 6.37, 95% CI: 1.32, 30.74), a HBsAg seropositive mothers, (AOR 11.19, (95% CI: 3.15, 39.67), and had no vaccination history for HBV (AOR, 6.37, 95% CI: 1.32, 30.74). Children from families with low monthly income, who were home delivered, unvaccinated for HBV or with HBsAg seropositive mother had increased risk of having anti-HBc. CONCLUSIONS: The study findings showed an intermediate endemicity of HBV infection in the study setting. The observed rate of residual HBV infection with low rate of immunized children after HBV vaccination was high. Hence, introducing birth dose vaccine, safe injection practice and improving immunization coverage during pregnancy as part of the antenatal care package should be considered. Furthermore, governmental and non-governmental organizations should give attention on timely measures for the prevention of ongoing vertical transmission from mother to child as well as early horizontal transmission of HBV in Hawassa City, Ethiopia.

Determinants of Knowledge, Attitude and Practice towards preventive measures of COVID-19 among adult residencies in Silte zone, Southern Ethiopia.

Introduction: coronavirus infectious disease-2019 (COVID-19) is currently a global health threat and an international public health emergency. There is a strong need to reinforce community knowledge, attitude and practice (KAP) to control the spread of the virus. The study aimed to identify the determinants of KAP towards preventive measures of COVID-19 among adult residencies. Methods: a community-based cross-sectional study design was employed in the communities of Silte zone, Southern Ethiopia. A total of 853 participants were selected using multistage stratified sampling technique. We used structured interview administered questionnaire. The KAP level was presented in descriptive and the associated variables conducted in binary logistic regression model. Results: overall, 81.7% had good knowledge, 78.4% had a positive attitude, and 43.9% had good practices. Being a female (Adjusted Odd Ratio (AOR): 2.3; 95% Confidence Interval (CI): 1.6-3.3), age between "31-40" (AOR: 1.99; 95% CI: 1-3.8) and able to read and write (AOR: 2.6; 95% CI: 1.7-3.7) were significantly associated factors of good knowledge towards COVID-19. Being urban resident (AOR: 1.8; 95% CI: 1.2-2.6) was significantly associated variable with positive attitude towards COVID-19. Being a government employee (AOR: 1.7; 95% CI: 1.1-2.7), able to read and write (AOR: 4.5; 95% CI: 3-6.7) and having good knowledge regarding COVID-19 (AOR: 2.4; 95% CI: 1.6-3.7) were significantly associated factors with good preventive practice towards COVID-19. Conclusion: alarmingly low preventive practice towards COVID-19 pandemic was indicated. Therefore, health education and promotion programs aimed at mobilizing and improving COVID-19-related practice are urgently needed, especially for those who are illiterate, having rural residency, or generally among underprivileged populations.

Assessment of knowledge, attitude and practice toward COVID-19 and associated factors among health care workers in Silte Zone, Southern Ethiopia.

INTRODUCTION: COVID-19 is a pandemic respiratory disease caused by the highly contagious novel coronavirus (SARS-CoV 2). The disease is now quickly spreading around the world, resulting in ongoing coronavirus pandemic. Healthcare workers are more susceptible to COVID-19 infection than the general population due to frequent contact with infected individuals. OBJECTIVE: This study was aimed to assess knowledge, attitude and practice towards COVID-19 and associated factors among health care workers. METHODS: Facility-based cross-sectional study design was conducted among health care workers in Silte Zone. A total of 379 health professionals were selected using multistage stratified sampling technique. Self-administered questionnaire was used to collect data. Binary logistic regression model was used to see association between outcome and independent variables. RESULTS: This study found 74.9%, 84.2% and 68.9% prevalence of adequate knowledge, positive attitude and good practice respectively. Working in comprehensive specialized hospital (AOR = 4.46, 95% CI = 1.46-13.62).having MSC degree (AOR = 10.26, 95% CI = 2.27-46.44), and training on COVID-19 (AOR = 6.59, 95% CI = 2.97-14.65) were strongly associated with knowledge of health care workers. On the other hand, older age (AOR = 3.35, 95% CI = 1.07-10.50), training on COVID-19 (AOR = 3.73, 95% CI = 1.82-7.63), Work experience (AOR = 3.78, 95% CI = 1.46-9.80) and Knowledge (AOR = 5.45, 95% CI = 2.60-11.43) were significantly associated with attitude, whereas source of information from friends or colleagues (AOR = 3.13, 95% CI = 1.28-7.66), working in primary hospital (AOR = 0.36, 95% CI = 0.21-0.620) and having good knowledge (AOR = 1.80, 95% CI = 1.03-3.14) were strongly associated with good practice of health care workers. CONCLUSION: This study found majority of health care workers had good level of knowledge and positive attitude toward COVID-19, but lower proportion of health care workers practices sufficiently in the study area. Type of health facilities, level of education, training on COVID-19, work experience, type of source of information were significantly associated with knowledge, attitude and practice of health care workers. Stakeholders need to focus on interventions that increase preventive practices of health care workers.