Cerebral function in perinatally HIV-infected young adults and their HIV-uninfected sibling controls.

BACKGROUND: Perinatally acquired HIV-infected (PaHIV) young adults undergo neurodevelopment in the presence of HIV infection and antiretroviral therapy, which may lead to neurocognitive (NC) impairment. Knowledge of NC function in this group is sparse and control data lacking. We compared cerebral function in young adults with PaHIV infection to aged matched HIV negative family controls. METHODS: 16-25-year-old PaHIV young adults (Group 1, n = 33) and HIV-uninfected family controls (Group 2, n = 14) were recruited. Cerebral function was evaluated by: a computerized battery assessing NC function (CogState(TM)), International HIV Dementia Scale (IHDS) and the prospective and retrospective memory questionnaire (PRMQ). Eight cases and four controls also underwent (1)H cerebral magnetic resonance spectroscopy ((1)H-MRS) scanning measuring basal ganglia (BG) metabolites. Cases and controls were compared. RESULTS: Group 1 mean (SD) CD4 count; 444 (319) cells/µl, plasma HIV viral load < 50 in 55%. There were no statistically significant differences between study groups in NC function or IHDS results (P>0.27 all observations). PRMQ scores were significantly higher (42 versus 35, P = 0.02) and MRS BG inflammatory-metabolites (choline- and myo-inositol- to creatine ratios) were significantly greater in Group 1 versus Group 2 (0.83 versus 0.63, P = 0.02 and 3.43 versus 3.03.P = 0.09 respectively). No significant association between PRMQ score and MRS metabolites was observed (P = 0.89). CONCLUSION: Statistically significant differences in cerebral function parameters were observed in PaHIV young adults compared to a well-matched control population. The cognitive deficit observed, in memory, rather than fine motor function, differs from the cerebral impairment often reported in HIV-infected adults.

Isolation prioritization tool: revision, adaptation and application.

The provision of single rooms for the care of patients who require isolation may not match the number required. Placing patients in isolation facilities may have an effect on their psychological wellbeing and the quality of care delivered. To ensure a rational and consistent approach to the prioritization of single room usage, an existing prioritization system was revised. This was validated by a group of experts and tested in an acute hospital. A simple short cut guide was developed and used.

Postorgasm illness syndrome--a spectrum of illnesses.

INTRODUCTION: We describe two men with marked symptoms following orgasm. In each case, the symptoms were consistent with those found in postorgasm illness syndrome (POIS). AIM: Further elucidation of the cause of the patients' symptoms. METHODS: Both cases were investigated for causes of POIS with biochemical, hormonal, neurological, autonomic, cardiological, and psychological workup. RESULTS: Extensive investigation did not reveal a major organic cause for these patients' symptoms. Detailed history revealed likely differing etiologies in each case. In one case, the symptom picture suggested cytokine release, and, in fact, the patient subjectively improved by 80% on taking nonsteroidal anti-inflammatory drugs just prior to and for a day or two after orgasm. The other case appeared to have an ethnic/cultural etiology that was associated with the "Dhat" syndrome. CONCLUSION: The apparent differing etiologies/clinical associations of these cases highlight the need for careful history, examination, and investigations in patients presenting with POIS. We recommend that each case needs individual consideration and investigation, and treatment needs to be tailored to the likely cause. It seems likely that POIS represents a spectrum of syndromes of differing etiologies. Further research into the neurobiochemical sequelae of orgasm will be useful in understanding the pathological processes in these cases.

The influence of number of syllables on word skipping during reading revisited.

Fitzsimmons and Drieghe (Psychonomic Bulletin & Review, 18, 736-741, 2011) showed that a monosyllabic word was skipped more often than a disyllabic word during reading. This finding was interpreted as evidence that syllabic information was extracted from the parafovea early enough to influence word skipping. In the present, large-scale replication of this study, in which we additionally measured the reading, vocabulary, and spelling abilities of the participants, the effect of number of syllables on word skipping was not significant. Moreover, a Bayesian analysis indicated strong evidence for the absence of the effect. The individual differences analyses replicate previous observations showing that spelling ability uniquely predicts word skipping (but not fixation times) because better spellers skip more often. The results indicate that high-quality lexical representations allow the system to reach an advanced stage in the word-recognition process of the parafoveal word early enough to influence the decision of whether or not to skip the word, but this decision is not influenced by number of syllables.

Prosodic phonological representations early in visual word recognition.

Two experiments examined the nature of the phonological representations used during visual word recognition. We tested whether a minimality constraint (R. Frost, 1998) limits the complexity of early representations to a simple string of phonemes. Alternatively, readers might activate elaborated representations that include prosodic syllable information before lexical access. In a modified lexical decision task (Experiment 1), words were preceded by parafoveal previews that were congruent with a target's initial syllable as well as previews that contained 1 letter more or less than the initial syllable. Lexical decision times were faster in the syllable congruent conditions than in the incongruent conditions. In Experiment 2, we recorded brain electrical potentials (electroencephalograms) during single word reading in a masked priming paradigm. The event-related potential waveform elicited in the syllable congruent condition was more positive 250-350 ms posttarget compared with the waveform elicited in the syllable incongruent condition. In combination, these experiments demonstrate that readers process prosodic syllable information early in visual word recognition in English. They offer further evidence that skilled readers routinely activate elaborated, speechlike phonological representations during silent reading.

The early processing of metaphors and similes: Evidence from eye movements.

This eye movement study examined how people read nominal metaphors and similes in order to investigate how the surface form, or wording, of these expressions affected early processing. Participants silently read metaphors (knowledge is a river) and similes (knowledge is like a river). The identical words were used in the topic-vehicle pair (knowledge-river) in both conditions. Experiments 1 and 2 demonstrated longer reading times and a higher proportion of regressions in metaphors than in similes. Familiarity modulated later metaphor effects in Experiment 1, but not in Experiment 2. Reading ability did not modulate the metaphor effects in Experiment 2. Results indicate that readers revised their initial interpretation of metaphors before moving on to read new text. This suggests that readers did not initially hold figurative interpretations of apt nominal metaphors that are somewhat familiar. Metaphor interpretation may be fast, but it is not easy.

Vowel processing during silent reading: evidence from eye movements.

Two eye movement experiments examined whether skilled readers include vowels in the early phonological representations used in word recognition during silent reading. Target words were presented in sentences preceded by parafoveal previews in which the vowel phoneme was concordant or discordant with the vowel phoneme in the target word. In Experiment 1, the orthographic vowel differed from the target in both the concordant and discordant preview conditions. In Experiment 2, the vowel letters in the preview were identical to those in the target word. The phonological vowel was ambiguous, however, and the final consonants of the previews biased the vowel phoneme either toward or away from the target's vowel phoneme. In both experiments, shorter reading times were observed for targets preceded by concordant previews than by discordant previews. Implications for models of word recognition are discussed.

Phonological activation of word meanings in grade 5 readers.

Three experiments examined the role of phonology in the activation of word meanings in Grade 5 students. In Experiment 1, homophone and spelling control errors were embedded in a story context and participants performed a proofreading task as they read for meaning. For both good and poor readers, more homophone errors went undetected than spelling control errors. In Experiments 2 and 3, homophone and spelling control errors were in sentence contexts. Experiment 2 used an online sentence verification task, and found that both good and poor readers were less accurate when sentences contained a homophone error than a spelling control error. Furthermore, a difference between the 2 types of sentences was observed even when participants were concurrently performing an articulation task. In Experiment 3, initial reading times were shorter on homophone errors than on spelling controls, and participants were less likely to make a regression from homophone errors than spelling controls. These experiments provide clear evidence that phonology makes an important contribution to the activation of word meanings in Grade 5 readers.

The prosodic property of lexical stress affects eye movements during silent reading.

The present study examined lexical stress in the context of silent reading by measuring eye movements. We asked whether lexical stress registers in the eye movement record and, if so, why. The study also tested the implicit prosody hypothesis, or the idea that readers construct a prosodic contour during silent reading. Participants read high and low frequency target words with one or two stressed syllables embedded in sentences. Lexical stress affected eye movements, such that words with two stressed syllables took longer to read and received more fixations than words with one stressed syllable. Findings offer empirical support for the implicit prosody hypothesis and suggest that stress assignment may be the completing phase of lexical access, at least in terms of eye movement control.

The effects of frequency and predictability on eye fixations in reading: implications for the E-Z Reader model.

Readers read sentences containing target words varying in frequency and predictability. The observed pattern of data for fixation durations only mildly departed from additivity, with predictability effects that were slightly larger for low-frequency than for high-frequency words. The pattern of data for skipping was different as predictability affected only the probability of skipping for high-frequency target words. Simulations of these data using the E-Z Reader model indicated that a single-process model was unlikely to provide a good fit for both measures. A version of the model that assumes that (a) word-encoding time is additively affected by frequency and predictability and (b) difficulty with postlexical processing of the target word causes a double take accounted for the data while indicating that the relationship between the duration of hypothesized word-encoding stages and observed fixation durations is not likely to be transparent.

Inhibition of saccade return in reading.

We examined the characteristics of readers' eye movements as they read sentences or short passages of text and compared the durations of eye fixations preceding two types of saccades: (a) saccades to words that were fixated on the prior fixation (return saccades) and (b) saccades in which the eyes moved about the same distance but did not land on a word fixated on the prior fixation (non-return saccades). Consistent with research from much simpler attention or oculomotor tasks, we found what could be considered an inhibition of return effect: fixations preceding return saccades were longer than those preceding non-return saccades.

Hypogonadism in human immunodeficiency virus-positive men.

In recent years, the life expectancy for those living with human immunodeficiency virus (HIV) with access to combined antiretroviral therapy (cART) has increased. As men live longer, the role testosterone plays in sexual function as well as in general well-being is becoming increasingly important. Here we discuss the available literature concerning androgens and HIV disease. A review was undertaken by using a PubMed search with the umbrella terms HIV or AIDS and testosterone or androgens spanning 1985 to 2011. Significant articles found in references in the primary search were also included. The reported prevalence of androgen deficiency appears to be greater in HIV-infected males than in the general population. Androgen deficiency is usually associated with low luteinizing hormone and follicle-stimulating hormone and is sensitive to the type of measurement of testosterone used. Rates of hypogonadism may be falling since the advent of cART. Causes of low testosterone levels have been attributed to chronic illness, HIV replication, cART, opportunistic infections, comorbidities and coinfections, wasting, and normal age-related declines. Studies of testosterone treatment in HIV-positive men are lacking in standardization and outcome measures.

Dyslexia and fluency: parafoveal and foveal influences on rapid automatized naming.

The ability to coordinate serial processing of multiple items is crucial for fluent reading but is known to be impaired in dyslexia. To investigate this impairment, we manipulated the orthographic and phonological similarity of adjacent letters online as dyslexic and nondyslexic readers named letters in a serial naming (RAN) task. Eye movements and voice onsets were recorded. Letter arrays contained target item pairs in which the second letter was orthographically or phonologically similar to the first letter when viewed either parafoveally (Experiment 1a) or foveally (Experiment 1b). Relative to normal readers, dyslexic readers were more affected by orthographic confusability in Experiment 1a and phonological confusability in Experiment 1b. Normal readers were slower to process orthographically similar letters in Experiment 1b. Findings indicate that the phonological and orthographic processing problems of dyslexic readers manifest differently during parafoveal and foveal processing, with each contributing to slower RAN performance and impaired reading fluency.