Type 2 diabetes mellitus pharmacological remission with dapagliflozin plus oral semaglutide.

Dapagliflozin, a sodium-glucose co-transporter-2 inhibitor and semaglutide, a glucagon-like peptide 1 receptor agonist, have both demonstrated efficacy in glycemic control, reducing blood pressure, body weight, risk of renal and heart failure in type 2 diabetes mellitus. In this observational, real-world, study we aimed to investigate the efficacy of the combination therapy with those two agents over glycemic control. We thus obtained the data of 1335 patients with type 2 diabetes followed by 11 Diabetes centers in Lombardia, Italy. A group of 443 patients was treated with dapagliflozin alone, the other group of 892 patients was treated with the combination therapy of dapagliflozin plus oral semaglutide. We analyzed changes in glycated hemoglobin from baseline to 6 months of follow-up, as well as changes in fasting glycemia, body weight, body mass index, systolic and diastolic pressure, heart rate, creatinine, estimated glomerular filtration rate and albuminuria. Both groups of patients showed an improvement of glycometabolic control after 6 months of treatment; indeed, the treatment with dapagliflozin plus oral semaglutide showed a reduction of glycated hemoglobin of 1.2% as compared to the 0.5% reduction observed in the dapagliflozin alone group. Significant changes were observed in body mass index, fasting plasmatic glucose, blood pressure, total cholesterol, LDL and albumin to creatinine ratio, with a high rate (55%) of near-normalization of glycated hemoglobin. Our real world data confirmed the potential of the oral combination therapy dapagliflozin with semaglutide in inducing pharmacological remission of type 2 diabetes mellitus.

[Efficacy of an emotional-based psycho-educational strategy for patients suffering from type 2 diabetes. An almost experimental pilot study]. / Efficacia di un intervento psicoeducativo a matrice emotiva per pazienti affetti da diabete di tipo 2. Uno studio pilota quasi sperimentale.

The authors discuss the creation of a psycho-educational course based on emotions in a group of diabetes type 2 patients. Its effects were assessed : biologically, by measuring blood sugar levels and body weight; cognitively, by behavioral tests; psycho-emotionally, by Moreno's Social Atom test that evaluates the patient's personal life in the light of his/her pathological conditions. 12 subjects were studied (10 patients and 2 spouses). Results showed: significant improvement in life-style; a marginal improvement of weight and level of coping with the illness; a non-significant improvement in blood sugar levels. The study showed that one particularly important aspect regards the role of nurses within the multidisciplinary team conducting the study.