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1.
Ann Biol Clin (Paris) ; 67(3): 343-8, 2009.
Artículo en Francés | MEDLINE | ID: mdl-19411238

RESUMEN

Erythema infectiosum (fifth disease) is the most common clinical presentation of acute parvovirus B19 infection in infancy. In healthy adults, most cases of infection are asymptomatic or accompanied by a flu-like syndrome like headaches and myalgia. Haematological manifestations are dominated by transient aplasia of erythroid progenitor cells which remains asymptomatic in most of non immunocompromised patients. Patients with sickle cell disease, thalassemia or other disorders associated with shortened red blood cell survival are at particular risk for marked anemia or red blood cell aplasia. In immunosuppressed patients, anemia may be chronic because of persistent viral load. Neutropenia, lymphopenia or thrombocytopenia have also been reported in acute parvovirus B19 infection. Mechanisms of these cytopenias are not yet elucidated. We present two patients with thrombopenia and/or neutropenia but without anemia due to acute parvovirus B19 infection.


Asunto(s)
Eritema Infeccioso/sangre , Eritema Infeccioso/diagnóstico , Neutropenia/virología , Infecciones por Parvoviridae/sangre , Infecciones por Parvoviridae/diagnóstico , Parvovirus B19 Humano/aislamiento & purificación , Trombocitopenia/virología , Adulto , Femenino , Humanos , Mielografía
3.
Bone Marrow Transplant ; 51(7): 928-32, 2016 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-27042842

RESUMEN

This report retrospectively analyzed the outcome of 91 patients aged 60 years or older with refractory/relapsed (R/R) classical Hodgkin's lymphoma (cHL) who underwent autologous stem cell transplantation (ASCT) between 1992 and 2013 and were reported to the French Society of Bone Marrow Transplantation and Cell Therapies registry. The median age at transplant was 63 years. The majority of patients exhibited disease chemosensitivity to salvage treatment (57 complete responses, 30 partial responses, 1 progressive disease and 3 unknown). The most frequent conditioning regimen consisted of BCNU, cytarabine, etoposide, melphalan (BEAM) chemotherapy (93%). With a median follow-up of 54 months, 5-year estimates of overall survival (OS) and progression free survival (PFS) for the entire group were 67 and 54%, respectively. Despite the missing data, in univariate analysis, the number of salvage chemotherapy lines (1-2 versus ⩾3) significantly influenced the OS, unlike the other prognostic factors (stage III-IV at relapse, disease status before ASCT and negative positron emission tomography (PET) scan) encountered in younger patients. In spite of its limitations, this retrospective study with a long-term follow-up suggests that ASCT is a valid treatment option for chemosensitive R/R cHL in selected elderly patients, with an acceptable rate of toxicity.


Asunto(s)
Trasplante de Células Madre Hematopoyéticas/métodos , Enfermedad de Hodgkin/terapia , Terapia Recuperativa/métodos , Factores de Edad , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Femenino , Estudios de Seguimiento , Trasplante de Células Madre Hematopoyéticas/efectos adversos , Trasplante de Células Madre Hematopoyéticas/mortalidad , Enfermedad de Hodgkin/mortalidad , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Terapia Recuperativa/mortalidad , Análisis de Supervivencia , Trasplante Autólogo
4.
AJNR Am J Neuroradiol ; 13(5): 1335-9, 1992.
Artículo en Inglés | MEDLINE | ID: mdl-1414825

RESUMEN

PURPOSE: To determine if the position of the superficial cerebral cortical veins can be used to distinguish subdural hygroma from atrophy on MR brain scans. METHODS: Retrospective review of MR scans obtained in cases of extracerebral fluid collections, separating these into two groups, ie, subdural hygroma or atrophy. FINDINGS: All cases of atrophy in this study showed cortical veins and their branches traversing widened cerebrospinal fluid spaces over the cerebral convexities. None of the subdural hygroma patients showed this finding. Cortical veins in hygroma patients were seen only at the margin of the displaced cortex, and did not traverse the fluid collections over the cerebral convexities. CONCLUSIONS: The authors call the visualization of cortical veins and their branches within fluid collections at the cerebral convexities "the cortical vein sign." They believe this sign to be prima facie evidence of atrophy; its presence rules out the diagnosis of subdural hygroma in the region of interest.


Asunto(s)
Neoplasias Encefálicas/diagnóstico , Encéfalo/patología , Corteza Cerebral/irrigación sanguínea , Venas Cerebrales/patología , Linfangioma/diagnóstico , Imagen por Resonancia Magnética , Atrofia , Diagnóstico Diferencial , Humanos , Espacio Subdural
5.
Acta Cytol ; 32(4): 485-8, 1988.
Artículo en Inglés | MEDLINE | ID: mdl-3400386

RESUMEN

A case of cutaneous leishmaniasis diagnosed by means of fine needle aspiration (FNA) cytology is presented. The pathognomonic cytopathologic picture consisted of lymphocytes, plasma cells and epithelioid granulomas intermingled with histiocytes. Numerous Leishmania organisms were observed within the histiocytes and extracellularly. This case emphasizes the utility of FNA cytology in diagnosing lesions of the skin.


Asunto(s)
Biopsia con Aguja , Leishmaniasis/patología , Animales , Niño , Citodiagnóstico , Femenino , Humanos , Leishmania/aislamiento & purificación , Leishmaniasis/parasitología
6.
Comput Med Imaging Graph ; 14(6): 431-5, 1990.
Artículo en Inglés | MEDLINE | ID: mdl-2272014

RESUMEN

A case of a large leiomyoma involving both the transverse colon and the greater curvature of the stomach is presented. Computed tomography (CT) demonstrated contiguous extension of the mass along the gastrocolic ligament. Although similar findings have been described in colonic and gastric carcinoma and in omental metastases, this is the first report in which these findings were due to a leiomyoma.


Asunto(s)
Neoplasias del Colon/diagnóstico por imagen , Leiomioma/diagnóstico por imagen , Ligamentos/diagnóstico por imagen , Neoplasias Gástricas/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Adulto , Femenino , Humanos
7.
Bone Marrow Transplant ; 49(7): 950-4, 2014 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-24710564

RESUMEN

Application of G-CSF in AML is controversial as leukemic blasts may express receptors interacting with the cytokine, which may stimulate leukemia growth. We retrospectively analyzed the impact of G-CSF use to accelerate neutrophil recovery after auto-SCT on outcome. Adults with AML in first CR autografted between 1994 and 2010 were included. Nine hundred and seventy two patients were treated with G-CSF after auto-SCT whereas 1121 were not. BM and PB were used as a source of stem cells in 454 (22%) and 1639 (78%) cases, respectively. The incidence of relapse at 5 years in the BM-auto-SCT group was 38% for patients receiving post-transplant G-CSF and 43% for those not treated with G-CSF, P=0.46. In the PB-auto-SCT cohort, respective probabilities were 48% and 49%, P=0.49. No impact of the use of G-CSF could be demonstrated with respect to the probability of leukemia-free survival: in the BM-auto-SCT group, 51% for G-CSF(+) and 48% for G-CSF(-), P=0.73; in PB-auto-SCT group, 42% for G-CSF(+) and 43% for G-CSF(-), P=0.83. Although G-CSF administration significantly shortened the neutropenic phase, no beneficial effect was observed with regard to non-relapse mortality. In patients with AML, the use of G-CSF after auto-SCT is not associated with increased risk of relapse irrespective of the source of stem cells used.


Asunto(s)
Factor Estimulante de Colonias de Granulocitos/uso terapéutico , Trasplante de Células Madre Hematopoyéticas/métodos , Leucemia Mieloide Aguda/terapia , Neutrófilos/efectos de los fármacos , Acondicionamiento Pretrasplante/métodos , Adolescente , Adulto , Anciano , Femenino , Humanos , Incidencia , Leucemia Mieloide Aguda/sangre , Leucemia Mieloide Aguda/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Neutrófilos/citología , Recurrencia , Estudios Retrospectivos , Adulto Joven
12.
Am J Physiol Imaging ; 6(4): 197-200, 1991.
Artículo en Inglés | MEDLINE | ID: mdl-1817573

RESUMEN

Radiographic identification of vicarious excretion of intravenous contrast into the stomach has not previously been cited in the literature. We report here an instance of gastric excretion of iodinated intravenous contrast following excretory urography in a severely burned patient. The physiology and possible pathways of vicarious excretion of contrast are discussed.


Asunto(s)
Quemaduras/diagnóstico por imagen , Diatrizoato de Meglumina , Mucosa Gástrica/metabolismo , Urografía , Adulto , Diatrizoato de Meglumina/administración & dosificación , Diatrizoato de Meglumina/metabolismo , Humanos , Inyecciones Intravenosas , Masculino
13.
Skeletal Radiol ; 27(12): 657-63, 1998 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-9921926

RESUMEN

OBJECTIVE: To assess the diagnostic value of the relationship between subcutaneous tumors and the superficial fascia in the characterization of soft-tissue masses. DESIGN: MR studies of 64 soft tissue masses located in the subcutaneous space were reviewed. We established five grades of relationship between tumors and superficial fascia and analyzed the probability of the lesions in each group being malignant. Group 1 tumors did not contact the fascia; group 2 lesions contacted it slightly, with acute angles between the tumor and the fascia; group 3 lesions had wider contact with larger acute or right angles; group 4 tumors had even wider contact with obtuse angles with the fascia; and group 5 was composed of lesions that crossed the superficial fascia. RESULTS: The probability of a subcutaneous lesion that crosses the superficial fascia being malignant was 6.88 times greater than for lesions that did not cross the fascia. For lesions forming obtuse angles with the fascia the probability of malignancy was 6.3 times greater than that of tumors that did not present this sign. All histologically verified fascial infiltrations occurred in malignant lesions of groups 4 and 5. CONCLUSIONS: Malignant tumors of the subcutaneous compartment have a higher tendency to develop a close relationship with the fascia than benign lesions. Obtuse angles between superficial fascia and a subcutaneous mass or a lesion crossing the fascia strongly suggest malignancy.


Asunto(s)
Fascia/patología , Imagen por Resonancia Magnética , Neoplasias de los Músculos/diagnóstico , Neoplasias de los Tejidos Blandos/diagnóstico , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/patología , Intervalos de Confianza , Medios de Contraste , Gadolinio DTPA , Hemangioma/diagnóstico , Hemangioma/patología , Histiocitoma Fibroso Benigno/diagnóstico , Histiocitoma Fibroso Benigno/patología , Humanos , Procesamiento de Imagen Asistido por Computador , Leiomiosarcoma/diagnóstico , Leiomiosarcoma/patología , Liposarcoma/diagnóstico , Liposarcoma/patología , Linfangioma/diagnóstico , Linfangioma/patología , Melanoma/diagnóstico , Melanoma/patología , Mesenquimoma/diagnóstico , Mesenquimoma/patología , Neoplasias de los Músculos/clasificación , Neoplasias de los Músculos/patología , Invasividad Neoplásica , Neoplasias de la Vaina del Nervio/diagnóstico , Neoplasias de la Vaina del Nervio/patología , Nevo/diagnóstico , Nevo/patología , Oportunidad Relativa , Estudios Retrospectivos , Sarcoma Sinovial/diagnóstico , Sarcoma Sinovial/patología , Neoplasias de los Tejidos Blandos/clasificación , Neoplasias de los Tejidos Blandos/patología
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