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1.
J Nematol ; 55(1): 20230012, 2023 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-37143484

RESUMEN

Globe artichoke (Cynara cardunculus var. scolymus L.) is a new alternative crop in Florida. This long-season crop poses a very high risk of root-knot nematode (RKN) damage, the most important nematode problem in vegetable production in Florida. This study aimed to examine the impact of RKN damage on artichoke production in the subtropical climate of Florida. Treatments consisted of four cultivars ('Green Globe Improved', 'Green Queen', 'Imperial Star', and 'Opal') planted on three different dates (October 5, October 19, and November 2) in Experiment 1, and three cultivars ('Green Globe Improved', 'Green Queen', and 'Imperial Star') grown with or without vernalization using gibberellic acid (GA3) in Experiment 2. Both field experiments were conducted on sandy soil in west-central Florida during the 2020-2021 and 2021-2022 growing seasons. We collected RKN population density and gall index (GI) data to assess RKN damage. In Experiment 1, all tested cultivars showed moderate to high RKN infection in the 2021-2022 season, with 43% to 75% of roots galled. There was no effect of planting dates on RKN damage in the 2020-2021 season. However, delaying the planting date from October 5 to November 2 reduced the RKN damage while increasing the RKN population densities in the 2021-2022 season. In Experiment 2, all tested cultivars showed high RKN infestation, with more than 80% of roots galled. Vernalization by GA3 did not affect the severity of RKN damage. Our results suggest that all tested artichoke cultivars are highly susceptible to RKN in subtropical environments of Florida, raising an alarm on the risk of RKN damage to commercial artichoke production and increasing awareness about the need for RKN management.

2.
Blood ; 134(20): 1764-1775, 2019 11 14.
Artículo en Inglés | MEDLINE | ID: mdl-31562136

RESUMEN

Hemostasis associated with tissue injury is followed by wound healing, a complex process by which damaged cellular material is removed and tissue repaired. Angiogenic responses are a central aspect of wound healing, including the growth of new lymphatic vessels by which immune cells, protein, and fluid are transported out of the wound area. The concept that hemostatic responses might be linked to wound healing responses is an old one, but demonstrating such a link in vivo and defining specific molecular mechanisms by which the 2 processes are connected has been difficult. In the present study, we demonstrate that the lymphangiogenic factors vascular endothelial growth factor C (VEGFC) and VEGFD are cleaved by thrombin and plasmin, serine proteases generated during hemostasis and wound healing. Using a new tail-wounding assay to test the relationship between clot formation and lymphangiogenesis in mice, we find that platelets accelerate lymphatic growth after injury in vivo. Genetic studies reveal that platelet enhancement of lymphatic growth after wounding is dependent on the release of VEGFC, but not VEGFD, a finding consistent with high expression of VEGFC in both platelets and avian thrombocytes. Analysis of lymphangiogenesis after full-thickness skin excision, a wound model that is not associated with significant clot formation, also revealed an essential role for VEGFC, but not VEGFD. These studies define a concrete molecular and cellular link between hemostasis and lymphangiogenesis during wound healing and reveal that VEGFC, the dominant lymphangiogenic factor during embryonic development, continues to play a dominant role in lymphatic growth in mature animals.


Asunto(s)
Hemostasis , Linfangiogénesis , Factor C de Crecimiento Endotelial Vascular/metabolismo , Animales , Plaquetas/metabolismo , Línea Celular , Femenino , Humanos , Masculino , Ratones , Activación Plaquetaria , Trombina/metabolismo , Factor D de Crecimiento Endotelial Vascular/metabolismo
3.
Plant Dis ; 2021 Apr 29.
Artículo en Inglés | MEDLINE | ID: mdl-33926199

RESUMEN

Thai basil (Ocimum basilicum var. thyrsiflora) is an important ethnic aromatic herb native to Southeast Asia. According to the Vegetable Production Handbook of Florida 2020-2021, Asian vegetables are currently grown on more than 4,000 ha in Florida, and Thai basil is one of the most commonly grown among these. Meloidogyne spp. cause severe damage to different basil cultivars (Brito et al. 2007). During May-July 2020, plant stunting and galled root symptoms were observed on Thai basil plants sampled from a commercial Asian vegetable farm in Wimauma, Florida (27°44.951' N; 82°16.271' E); 1,972 root-knot nematode second-stage juveniles (J2s) were extracted from 200 cm3 soil. A pathogenicity test was performed in September 2020 at the University of Florida Gulf Coast Research and Education Center, Wimauma, Florida. Ten of 20, three-week-old nematode-free Thai basil plants were inoculated with 5,000 eggs of field nematode cultures. Two months after inoculation (temperature = 22.8 ± 3.8 °C, relative humidity = 85.6 ± 14.0 %), average gall index (Bridge and Page 1980) = 5.4 ± 1.1 were only observed in inoculated plants, and 69,276 ± 18,904 eggs were extracted from roots using the NaClO method (Hussey and Barker 1973); 5 ± 7 J2s / 200 cc soil were recovered by the modified Baermann funnel technique (Forge and Kimpinski 2007). Nematode reproduction factor (RF) = 13.86 ± 3.78 (Nicol et al. 2010). Morphological measurements (mean, standard deviation and range) of J2s (n=20) included body length = 394.0 ± 22.3 (362.8 - 437.9) µm, body width = 15.7 ± 1.2 (13.6 - 18.3) µm, and stylet length = 12.8 ± 1.1 (10.4-14.5) µm. The perineal pattern of matured female (n=5) was oval-shaped with coarse and smooth striate; the dorsal arch was high and round; no lateral line presented. Morphological characteristics of females and J2s were consistent with those described for M. enterolobii (Yang and Eisenback 1983). DNA was extracted from a single female picked from infected Thai basil root using NaOH digestion method (Hübschen et al. 2004). The D2-D3 expansion segment of 28S rDNA and the COXII region on mitochondrial DNA were amplified by PCR using the primers 28S391a/28S501 and C2F3/1108 (Ye et al. 2020); the species was also confirmed with species-specific primers Me-F/Me-R (Ye et al. 2020). PCR products were sequenced by the Genomic Sciences Laboratory (North Carolina State University, Raleigh, NC, USA) and the results were recorded in the NCBI with GeneBank Accession Nos. MW488150 and MW507374. The sequences showed 100% identity with M. enterolobii in D2/D3 (KP901079, KP411230) and COXII (MN809527, KX214350). M. enterolobii (M. mayaguensis) has been reported on sweet basil in Florida (Brito et al. 2008). To our knowledge, this is the first detection of M. enterolobii on Thai basil in Hillsborough County, Florida. It is not clear to what extent M. enterolobii reduces the yield of Thai basil, but the RF value obtained in the pathogenicity test indicates the crop is certainly a very good host. Limited information is available on the distribution of M. enterolobii in Florida and the US. M. enterolobii is known to break down the root-knot resistance of crops including soybean, sweet potatoes, and tomatoes (Philbrick et al. 2020). This nematode is considered one of the major emerging threats to agriculture in the southeastern US. A multistate research and outreach program (FINDMe program) was initiated in 2019 to study the distribution and management of this nematode in the southeastern US.

4.
J Strength Cond Res ; 35(12): 3466-3473, 2021 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-31809459

RESUMEN

ABSTRACT: Allisse, M, Bui, HT, Desjardins, P, Léger, L, Comtois, AS, and Leone, M. Assessment of on-ice oxygen cost of skating performance in elite youth ice hockey players. J Strength Cond Res 35(12): 3466-3473, 2021-The purpose of this study was to evaluate the robustness of equations to predict the oxygen requirement during different skating circumstances commonly found in ice hockey game situations (skating forward, backward, with and without controlling a puck, during cornering and stops and starts). Twenty-four male elite ice hockey players from 3 categories (pee-wee, bantam, and midget) participated in this study. Anthropometric measurements were taken, and 4 different on-ice high-intensity and short-duration tests were performed. Execution time, heart rate, oxygen uptake, skating strides, and a skating efficiency index were measured for each test. A regression equation was calculated for each of the 4 tests providing an estimation of oxygen cost. Correlation coefficients ranged from 0.91 to 0.93, and SEE was between 4.5 and 8.4%, indicating that the precision of the regression algorithms was excellent. The results also suggest that execution time alone, which is the traditional manner to measure skating performance, is a bad estimator of oxygen uptake requirement for this kind of effort (average common variance <11%). Furthermore, age proved to be a determining factor with younger players showing an overall lower level of skating efficiency compared with older players. In addition, the introduction of a skating index also helps to better determine which factor of performance needs to be improved. Using simple and easy-to-measure variables, coaches will be able to obtain information that will allow them to intervene more precisely on the training parameters that will optimize the individual on-ice performance of their players.


Asunto(s)
Hockey , Patinación , Adolescente , Prueba de Esfuerzo , Frecuencia Cardíaca , Humanos , Masculino , Oxígeno
5.
J Nematol ; 532021.
Artículo en Inglés | MEDLINE | ID: mdl-33860253

RESUMEN

Soil fumigation remains the standard practice to manage soilborne pathogens such as plant-parasitic nematodes, bacteria, and fungi, especially in high-value crops. However, increasing regulatory pressure due to the inherent and broad-spectrum toxicity and negative environmental impact of chemical soil fumigants, its negative effect on overall soil health, and increasing demand for organic produce, has created a growing interest in biological fumigants. Many plants and microorganisms emit volatile compounds, which can potentially be used as bio-fumigants. In this mini-review, we summarize the current status of nematology studies focused on the development of volatile compounds emitted from plants and microorganisms as fumigants to control plant-parasitic nematodes. The gap of knowledge and challenges of studying volatile compounds are also addressed.

6.
J Strength Cond Res ; 34(11): 3182-3189, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33105369

RESUMEN

Allisse, M, Bui, HT, Léger, L, Comtois, A-S, and Leone, M. Updating the skating multistage aerobic test and correction for V[Combining Dot Above]O2max prediction using a new skating economy index in elite youth ice hockey players. J Strength Cond Res 34(11): 3182-3189, 2020-A number of field tests, including the skating multistage aerobic test (SMAT), have been developed to predict V[Combining Dot Above]O2max in ice hockey players. The SMAT, like most field tests, assumes that participants who reach a given stage have the same oxygen uptake, which is not usually true. Thus, the objectives of this research are to update the V[Combining Dot Above]O2 values during the SMAT using a portable breath-by-breath metabolic analyzer and to propose a simple index of skating economy to improve the prediction of oxygen uptake. Twenty-six elite hockey players (age 15.8 ± 1.3 years) participated in this study. The oxygen uptake was assessed using a portable metabolic analyzer (K4b) during an on-ice maximal shuttle skate test. To develop an index of skating economy called the skating stride index (SSI), the number of skating strides was compiled for each stage of the test. The SMAT enabled the prediction of the V[Combining Dot Above]O2max (ml·kg·min) from the maximal velocity (m·s) and the SSI (skating strides·kg) using the following regression equation: V[Combining Dot Above]O2max = (14.94 × maximal velocity) + (3.68 × SSI) - 24.98 (r = 0.95, SEE = 1.92). This research allowed for the update of the oxygen uptake values of the SMAT and proposed a simple measure of skating efficiency for a more accurate evaluation of V[Combining Dot Above]O2max in elite youth hockey players. By comparing the highest and lowest observed SSI scores in our sample, it was noted that the V[Combining Dot Above]O2 values can vary by up to 5 ml·kg·min. Our results suggest that skating economy should be included in the prediction of V[Combining Dot Above]O2max to improve prediction accuracy.


Asunto(s)
Prueba de Esfuerzo/métodos , Hockey/fisiología , Consumo de Oxígeno , Patinación/fisiología , Adolescente , Niño , Humanos , Masculino
7.
J Nematol ; 50(1): 27-32, 2018 May 31.
Artículo en Inglés | MEDLINE | ID: mdl-30335909

RESUMEN

Steinernema carpocapsae is an entomopathogenic nematode widely studied for its properties as a biocontrol agent in insect pest management and as a model for understanding bacterial symbioses. Less attention has been given to the development of specific anatomical structures within S. carpocapsae. A better understanding of entomopathogenic nematode development and anatomy may lead to improved biocontrol efficacy. We recently demonstrated that the neuroanatomy of S. carpocapsae IJs differs from the dauer stage of Caenorhabditis elegans. Here, we used in vitro cultures of S. carpocapsae to examine the early development of the ventral nerve cord (VNC). Similar to C. elegans, S. carpocapsae hatches as a J1 with a VNC containing only a fraction of the neurons found in later developmental stages. During J1 development, S. carpocapsae adds additional cells to the VNC to establish the complete set of neurons. During our examination of the VNC, we also noted variable gonad arm development among S. carpocapsae individuals. Using synchronized in vitro cultures, we found that the gonad migration pattern in S. carpocapsae was distinct from both C. elegans and the Diplogaster nematode Pristionchus pacificus. The S. carpocapsae gonad arm migration was highly variable.

8.
Aging Clin Exp Res ; 29(2): 239-246, 2017 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-26971801

RESUMEN

The goal of the present research was to compare the bioenergetics variability of walking, during the 6-min walk test (6-MWT) and a multistage incremental shuttle walk test (MISWT) in an active older population. Twenty-two healthy physically active older adults with a group mean age of 70.4 ± 5.8 years completed the 6-MWT and the MISWT. Heart rate (HR), walking speed and walking [Formula: see text]O2 were measured throughout each test with a portable metabolic cart. Strong correlations were found for the [Formula: see text]O2 peak and the walking speed (r = 0.91 and r = 0.89 respectively for 6-MWT and MISWT). Differences in [Formula: see text]O2 peak values were analysed with a paired Student's t test. Repeated measures ANOVA were conducted to detect differences between tests. The Bland and Altman plot indicates that the average difference between both tests was 2.5 ml kg-1 min-1. MISWT [Formula: see text]O2 peak means were significantly greater than the 6-MWT [Formula: see text]O2 peak mean values (21.6 ± 5.3 vs. 18.9 ± 4.5 ml kg-1 min-1) which indicate bioenergetics differences between the two walking tests. Thus, the MISWT and 6-MWT elicited different walking [Formula: see text]O2 peak and HR suggesting that the MISWT field test challenge the participants to a higher level of cardiovascular and respiratory stress. The walking [Formula: see text]O2 peak recorded for the MISWT was significantly greater than the 6-MWT. Consequently, both tests seem to measure different facets of the aerobic capacity. MISWT seems to be a better indicator of maximal aerobic power whereas the 6-MWT provides more relevant information regarding aerobic endurance in aging population.


Asunto(s)
Envejecimiento/fisiología , Umbral Anaerobio/fisiología , Tolerancia al Ejercicio/fisiología , Caminata/fisiología , Anciano , Metabolismo Energético , Femenino , Evaluación Geriátrica/métodos , Frecuencia Cardíaca/fisiología , Humanos , Masculino , Persona de Mediana Edad , Prueba de Paso/métodos , Velocidad al Caminar/fisiología
9.
Blood ; 121(16): 3228-36, 2013 Apr 18.
Artículo en Inglés | MEDLINE | ID: mdl-23426945

RESUMEN

The secreted protein CCBE1 is required for lymphatic vessel growth in fish and mice, and mutations in the CCBE1 gene cause Hennekam syndrome, a primary human lymphedema. Here we show that loss of CCBE1 also confers severe anemia in midgestation mouse embryos due to defective definitive erythropoiesis. Fetal liver erythroid precursors of Ccbe1 null mice exhibit reduced proliferation and increased apoptosis. Colony-forming assays and hematopoietic reconstitution studies suggest that CCBE1 promotes fetal liver erythropoiesis cell nonautonomously. Consistent with these findings, Ccbe1(lacZ) reporter expression is not detected in hematopoietic cells and conditional deletion of Ccbe1 in hematopoietic cells does not confer anemia. The expression of the erythropoietic factors erythropoietin and stem cell factor is preserved in CCBE1 null embryos, but erythroblastic island (EBI) formation is reduced due to abnormal macrophage function. In contrast to the profound effects on fetal liver erythropoiesis, postnatal deletion of Ccbe1 does not confer anemia, even under conditions of erythropoietic stress, and EBI formation is normal in the bone marrow of adult CCBE1 knockout mice. Our findings reveal that CCBE1 plays an essential role in regulating the fetal liver erythropoietic environment and suggest that EBI formation is regulated differently in the fetal liver and bone marrow.


Asunto(s)
Anemia/embriología , Proteínas de Unión al Calcio/genética , Eritropoyesis , Feto/metabolismo , Hígado/metabolismo , Proteínas Supresoras de Tumor/genética , Anemia/genética , Anemia/metabolismo , Anemia/patología , Animales , Médula Ósea/metabolismo , Proteínas de Unión al Calcio/metabolismo , Células Cultivadas , Pérdida del Embrión/genética , Embrión de Mamíferos/embriología , Embrión de Mamíferos/metabolismo , Embrión de Mamíferos/patología , Eritroblastos/citología , Eritroblastos/metabolismo , Eritroblastos/patología , Eritropoyetina/genética , Eritropoyetina/metabolismo , Feto/patología , Eliminación de Gen , Hígado/patología , Sistema Linfático/embriología , Ratones , Factor de Células Madre/genética , Factor de Células Madre/metabolismo , Proteínas Supresoras de Tumor/metabolismo
10.
Pediatr Blood Cancer ; 61(1): 46-52, 2014 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-24115507

RESUMEN

BACKGROUND: The purpose of this study was to evaluate the usefulness of a new gross motor skill test battery in acute lymphoblastic leukemia (ALL) children who have been off therapy for at least 1 year and to assess its discriminatory power (discriminant analysis) from healthy children. PROCEDURE: Twenty children (10 males and 10 females) 9-11 years of age (median age = 10.6 years) were assessed by the UQAC-UQAM test battery and then compared to recent provincial norms. This pilot study was also an opportunity to validate this test battery as a reliable tool for clinical or research purposes in the area of chronic or disabling diseases in children. Eleven motor skill variables grouped into five factors have been measured (speed, agility, balance, coordination, and reaction time). RESULTS: Scores from 10 of the 11 motor skill tests showed significant differences when compared to the control group (P ≤ 0.05). Nearly 50% of patients obtained an average score below the 15th percentile. Furthermore, stepwise discriminant analysis allowed classifying successfully 88.4% of children in the correct group (ALL or Control). The normal development of GMS among children affected by ALL appears to have been compromised. The UQAC-UQAM test battery seems to be sensitive enough to quantify with precision the extent of the motor impairment in these children. CONCLUSION: The UQAC-UQAM test battery appears to be a useful tool to evaluate the extent to which ALL survivors are affected. Early motor intervention should be considered for those patients even during the treatment periods.


Asunto(s)
Antineoplásicos/efectos adversos , Destreza Motora/efectos de los fármacos , Examen Neurológico/métodos , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico , Sobrevivientes/estadística & datos numéricos , Niño , Femenino , Humanos , Masculino , Fenotipo , Proyectos Piloto
11.
Artículo en Inglés | MEDLINE | ID: mdl-38673321

RESUMEN

BACKGROUND: Adolescents who experience overweight or obesity commonly persist in these conditions into adulthood, thereby elevating their vulnerability to health issues. The focus of this study is on health risk markers such as body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), body surface area (BSA), and cardiorespiratory fitness (CRF). The objectives include updating normative values for BMI, WC, WHtR, and BSA in Canadian adolescents, establishing cardiometabolic risk zones, and developing a composite score considering both anthropometric and CRF markers. METHODS: Involving 1864 adolescents, the study used the LMS method to generate percentile norms, stratified by age and sex. Cardiometabolic risk zones were established for each marker based on Z-scores, and a composite score was created. RESULTS: An increase in WC of 5.8 and 7.4 cm for boys and girls, respectively, was observed since 1981. Forward multiple regression analyses were conducted to assess the robustness and validity of the proposed model. The results indicated that the model explained nearly 90% (R2 = 0.890) of the common variance between the composite score and the retained independent variables. Moreover, the model demonstrated a mean absolute error (MAE) of approximately 6 percentiles, confirming its high precision. Furthermore, these analyses yielded key thresholds for identifying adolescents at risk: the 70th percentile for high cardiometabolic risk and the 85th percentile for very-high risk. CONCLUSIONS: Individually, WC or WHtR seem to be better markers for evaluating cardiometabolic risk than BMI during adolescence. However, CRF showed comparable importance to anthropometric markers in determining cardiometabolic risk. The simultaneous inclusion of anthropometric and CRF markers provides a better picture of the global cardiometabolic risk in adolescents.


Asunto(s)
Capacidad Cardiovascular , Sobrepeso , Humanos , Adolescente , Masculino , Femenino , Canadá , Índice de Masa Corporal , Antropometría , Circunferencia de la Cintura , Relación Cintura-Estatura , Obesidad Infantil , Niño
12.
Artículo en Inglés | MEDLINE | ID: mdl-38928918

RESUMEN

BACKGROUND: In addition to the inherent challenges of their condition, children with autism spectrum disorder (ASD) are also susceptible to the global obesity epidemic. However, concerning the prevalence of obesity within the Moroccan ASD pediatric population, data remain scarce. METHODS: A total of 258 children (boys = 195) aged 6 to 12 years old (mean = 9.4 ± 1.4) diagnosed with ASD participated in this study. Besides the body mass and height, four significant anthropometric markers for assessing obesity were examined: body mass index (BMI), body surface area (BSA), waist circumference (WC), and waist-to-height ratio (WHtR). Each anthropometric marker was categorized into one of three cardiometabolic risk levels based on the Z-scores and their corresponding percentiles. The distribution was as follows: low risk (≤84th percentile), high risk (85th-94th percentile), and very high risk (≥95th percentile). Subsequently, a multiple regression analysis was employed to develop an algorithm that generates a composite risk score. This score incorporates all the anthropometric variables simultaneously, while also weighting their individual contributions to the cardiometabolic risk. RESULTS: Children with ASD exhibit an anthropometric profile that markedly increases their susceptibility to cardiometabolic issues. While roughly 11% of the general Moroccan child population is overweight or obese, this figure soars to nearly 60% among children with ASD when considering the central adiposity markers. Furthermore, children from middle-class socioeconomic backgrounds display a more than threefold greater risk of developing overweight or obesity compared to their counterparts from lower socioeconomic backgrounds. CONCLUSIONS: This study has, for the first time, provided an up-to-date overview of the cardiometabolic risk in Moroccan children with ASD using traditional anthropometric measurements. The primary risk factor is clearly linked to central (abdominal) adiposity, which is recognized as the most deleterious. This study highlights the need to include general and central obesity markers. This study underscores the importance of incorporating both general and central adiposity markers for a more comprehensive assessment, and it emphasizes the need for closer monitoring within this high-risk population.


Asunto(s)
Trastorno del Espectro Autista , Sobrepeso , Humanos , Trastorno del Espectro Autista/epidemiología , Masculino , Femenino , Marruecos/epidemiología , Niño , Prevalencia , Sobrepeso/epidemiología , Antropometría , Factores Socioeconómicos , Obesidad Infantil/epidemiología , Circunferencia de la Cintura , Índice de Masa Corporal
14.
Nat Genet ; 32(2): 312-5, 2002 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-12355088

RESUMEN

Liver adenomas are benign tumors at risk of malignant transformation. In a genome-wide search for loss of heterozygosity (LOH) associated with liver adenomas, we found a deletion in chromosome 12q in five of ten adenomas. In most cases, LOH at 12q was the only recurrent genetic alteration observed, suggesting the presence of a tumor-suppressor gene in that region. A minimal common region of deletion was defined in 12q24 that included the gene TCF1 (transcription factor 1), encoding hepatocyte nuclear factor 1 (HNF1; refs 1,2). Heterozygous germline mutations of TCF1 have been identified in individuals affected with maturity-onset diabetes of the young type 3 (MODY3; ref. 3). Bi-allelic inactivation of TCF1 was found in 10 of 16 screened adenomas, and heterozygous germline mutation were present in three affected individuals. Furthermore, 2 well-differentiated hepatocellular carcinomas (HCCs) occurring in normal liver contained somatic bi-allelic mutations of 30 screened HCCs. These results indicate that inactivation of TCF1, whether sporadic or associated with MODY3, is an important genetic event in the occurrence of human liver adenoma, and may be an early step in the development of some HCCs.


Asunto(s)
Adenoma/genética , Proteínas de Unión al ADN , Neoplasias Hepáticas/genética , Proteínas Nucleares , Factores de Transcripción/genética , Adenoma/fisiopatología , Adulto , Anciano , Cromosomas Humanos Par 12 , Diabetes Mellitus Tipo 2/genética , Femenino , Marcadores Genéticos , Factor Nuclear 1 del Hepatocito , Factor Nuclear 1-alfa del Hepatocito , Factor Nuclear 1-beta del Hepatocito , Humanos , Neoplasias Hepáticas/metabolismo , Pérdida de Heterocigocidad , Masculino , Repeticiones de Microsatélite , Persona de Mediana Edad , Mutación Missense , Análisis de Secuencia de ADN
15.
Pest Manag Sci ; 79(11): 4474-4480, 2023 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-37409379

RESUMEN

BACKGROUND: The efficacy of drip-applied nematicides depends on adequate product distribution, which can be difficult in sandy soils. Three new non-fumigant nematicides (fluazaindolizine, fluensulfone, fluopyram), together with two old nematicides, oxamyl and metam potassium, were evaluated when applied via single and double drip tapes to control root-knot nematode in cucumber and squash in Florida between February 2020 and December 2022. RESULTS: Nematicide applications via double drip tapes resulted in lower root gall infection (and tend to have higher yield) as compared to a single tape for fluopyram, but no difference was noted between single and double tapes for oxamyl and fluazaindolizine. Fluensulfone response was somewhere in between and metam potassium had higher squash yield when applied with double tapes. Root-knot infection was higher in cucumber than in squash, and metam potassium had the highest yields and lowest nematode infection compared to other nematicide treatments. CONCLUSION: The benefit of double versus single drip tapes depended on the type of nematicide that was applied and was evident for nematicides that have poor water solubility like fluopyram. Some benefit was noted for metam potassium, but no or limited benefit was noted for oxamyl, fluazaindolizine and fluensulfone. © 2023 Society of Chemical Industry.

16.
Heliyon ; 9(3): e13743, 2023 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-36873533

RESUMEN

Recent research has shown writing strategies to have a substantial impact on language learners' writing performance but little is known about what strategies EFL learners use and how they use them in writing academic texts such as reports, final assignments, and project papers. The study reported in this paper extends this line of research by investigating the strategies Vietnamese EFL pre-service teachers use in academic writing. Data included document analysis of 17 pre-service teachers' final assignment papers (one paper per teacher) and individual semi-structured interviews with ten teachers. The study adopted a content-based approach to qualitative data analysis with reference to a comprehensive research-based taxonomy for L2 academic writing strategies, including rhetorical, metacognitive, cognitive, and social affective strategies. The results show that rhetorical, metacognitive, and cognitive strategies were most frequently used by the teacher participants. The results further show that self-efficacy and self-regulation determined the teachers' use of strategies during the writing process. Implications for the L2 writing classroom focused on academic writing strategies to enhance pre-service teachers' writing quality will be discussed.

17.
Environ Sci Pollut Res Int ; 30(53): 114249-114263, 2023 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-37861823

RESUMEN

The Association of Southeast Asian Nations (ASEAN), a new global economic force, has struggled to achieve a dual objective of enhanced economic growth and improved environmental quality. Financial development is generally considered an important tool in achieving these simultaneous objectives. This paper examines the response mechanism and the inter-relationship between the ASEAN region's financial development, energy consumption, and economic growth. Unlike previous studies, the paper uses a generalized method of moments panel vector autoregression (GMM-panel VAR) framework for the 1981-2021 period. The second-generation Granger causality test is used to identify their causality relationship. Economic growth supports financial development and reduces energy consumption from fossil fuel sources in the ASEAN countries. Financial development also reduces fossil fuel energy consumption. The bi-directional relationship between economic growth and fossil fuel energy consumption exists. Energy consumption and financial development are also bi-directionally linked. However, only the unidirectional Granger causality from economic growth to financial development is found. The variance decomposition analysis results confirm that economic growth accounts for the most significant variance in fossil fuel energy consumption and financial development in the ASEAN countries. Policy implications have emerged based on these findings.


Asunto(s)
Dióxido de Carbono , Desarrollo Económico , Dióxido de Carbono/análisis , Asia , Fuentes Generadoras de Energía , Combustibles Fósiles , Energía Renovable
18.
Int J Exerc Sci ; 16(4): 1385-1397, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-38288069

RESUMEN

The lack of specific on-ice tests to predict maximum lactate concentration limits the ability of coaches to better track and develop their ice hockey players. Thus, this study aimed to develop an equation for indirectly assessing the maximum lactate concentration produced from an all-out on-ice skating effort in elite adolescent ice hockey players. Twenty elite male ice hockey players participated in this study (age = 15.7 ± 1.0 year). The lactate anaerobic skating test (LAST) consisted of skating back and forth on an 18.2 m course at maximal speed with abrupt stops at each end for a total of 6 shuttles (total distance = 218.2 m; average time = 52.0 ± 2.0 s). The oxygen uptake was measured using a portable metabolic analyzer (Cosmed K4b2) and the maximum post-exercise lactate concentration with a Lactate Pro analyzer. The variables used to estimate lactate concentration were time, heart rate, number of skating strides in the last shuffle (6th) and the skating stride index. The average maximum lactate concentration was 14.4 mmol· L-1, which is expected in elite players. The analysis of explained common variance using T-test (r2 = 0.759) and linear regression (r2 = 0.863) demonstrates the validity of the model. Additionally, the root mean square error (RMSE = 0.60 mmol· L-1), the mean absolute error (MAE = 0.45mmol· L-1) and the standard error of estimate (SEE = 0.69 mmol· L-1) values further confirm the accuracy of the model. Thus, using simple and easy-to-measure variables (i.e., time and skating stride), coaches will be able to monitor more effectively their players' progress in an effort to optimize their individual on-ice performance.

19.
Can J Public Health ; 114(4): 629-641, 2023 08.
Artículo en Inglés | MEDLINE | ID: mdl-37074556

RESUMEN

OBJECTIVE: The main objective of this study was to examine secular trends in body mass, body height and body mass index (BMI) from measured rather than self-reported values between 1972 and 2017. METHODS: A total of 4500 students (males = 51%) were selected from a stratified sampling. The age range varied between 6.0 and 17.9 years. The sample came from 24 elementary schools and 12 high schools located in six urban cities from the province of Québec. All the tests selected were based on standardized procedures that are recognized as valid and reliable. Standardization and modeling of smoothed percentile curves for each variable for both sexes were produced. RESULTS: Regional variations between youth from the province of Québec and those from all other Canadian provinces confirm the relevance of using data specific to the target population. Comparisons with the 1972 and 1982 data show an important increase in body mass (~ 7 kg, i.e. 16.4%) and BMI (~ 1.4 kg·m-2, i.e. 19.9%) with minor change in body height (~ 1.8 cm, i.e. 3.9%). Youth from low-income backgrounds (p = 0.001) as well as those living in large urban cities (p = 0.002) see their probability of developing overweight or obesity greatly increase (low-income = 2.1 times; large urban cities = 1.3 times). However, overweight and obesity rates seem to have stabilized at around 21% since 2004. CONCLUSION: This study provides up-to-date data on factors that contribute to the prevalence of overweight and obesity in youth in urban settings of Québec, and will be instrumental in guiding public health strategies designed to optimize growth outcomes.


RéSUMé: OBJECTIF: L'objectif principal de cette étude était d'examiner les tendances séculaires de la masse corporelle, de la taille et de l'indice de masse corporelle (IMC) de 1972 à 2017 à partir de valeurs mesurées plutôt que de valeurs autodéclarées. MéTHODE: Un total de 4 500 étudiants (garçons = 51 %) ont été sélectionnés à partir d'un échantillon stratifié. La fourchette d'âge variait entre 6,0 et 17,9 ans. L'échantillon provenait de 24 écoles primaires et 12 écoles secondaires situées dans six villes de la province de Québec (Canada). Tous les tests sélectionnés reposaient sur des procédures standardisées, reconnues comme valides et fidèles. Une standardisation et une modélisation des courbes centiles lissées ont été produites pour chaque variable pour les deux sexes. RéSULTATS: Les variations régionales entre les jeunes du Québec et ceux du reste du Canada confirment la pertinence d'utiliser des données spécifiques à la population cible. Les comparaisons entre les données de 1972 et de 1982 montrent une augmentation importante de la masse corporelle et de l'IMC (p ≤ 0,05) sans changement important de la taille corporelle. Les jeunes issus de milieux à faibles revenus (p = 0,001) ainsi que ceux vivant dans les grandes villes (p = 0,002) voient leurs risques de développer un surpoids ou de l'obésité augmenter considérablement (faibles revenus = 2,1 fois; grandes villes urbaines = 1,3 fois). Toutefois, les taux de surpoids et d'obésité semblent s'être stabilisés autour de 21 % depuis 2004. CONCLUSION: Cette étude fournit des données à jour sur les facteurs qui contribuent à la prévalence de l'embonpoint et de l'obésité chez les jeunes des milieux urbains du Québec et contribuera à orienter les stratégies de santé publique afin d'optimiser le suivi sur la croissance physique des jeunes.


Asunto(s)
Estatura , Sobrepeso , Masculino , Femenino , Adolescente , Niño , Humanos , Índice de Masa Corporal , Peso Corporal , Sobrepeso/epidemiología , Quebec/epidemiología , Estudios Transversales , Canadá , Obesidad/epidemiología , Prevalencia
20.
Heliyon ; 8(9): e10628, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-36158095

RESUMEN

Given the importance of ESP teaching, this study explores and compares students' and teachers' perceptions of effective ESP teaching. The researcher administered a 32-item Likert-scale questionnaire to 248 participants (216 students and 32 teachers) at five universities in Vietnam. The participants were then stratified to select 20 participants (fifteen students and five teachers) for interviews. Results showed that there were significant discrepancies between students and teachers' perceptions of four categories: task-based language teaching, corrective feedback and assessment, discipline specifications, and culture integration. However, students' and teachers' perceptions of three categories, namely language use, application of technologies, and grammar teaching, were aligned. Interview data generally confirmed the quantitative results and provided more insights into what the participants thought. It might be important for teachers to present their concerns about ESP teaching to students and understand students' needs and expectations to bridge the gaps.

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