Safety and efficacy of SARS-CoV-2 vaccination in 1237 patients with primary Sjögren syndrome.

OBJECTIVES: To investigate the safety and efficacy of SARS-Cov-2 vaccination in patients with primary Sjögren syndrome (pSS) due to scarcity of data in this population. METHODS: By the first week of May 2021, all Big Data SS Consortium centres patients who had received at least one dose of any SARS-CoV-2 vaccine were included in the study. The in-charge physician asked patients about local and systemic reactogenicity to collect SARS-CoV-2 vaccination data. RESULTS: The vaccination data of 1237 patients were received. A total of 835 patients (67%) reported any adverse events (AEs), including local (53%) and systemic (50%) AEs. Subjective symptoms (63%) were the most common local AEs, followed by objective signs at the injection site (16%), and general symptoms were the most commonly reported systemic AEs (46%), followed by musculoskeletal (25%), gastrointestinal (9%), cardiopulmonary (3%), and neurological (2%). In addition, 141 (11%) patients reported a significant worsening/exacerbation of their pre-vaccination sicca symptoms and fifteen (1.2%) patients reported active involvement in the glandular (n=7), articular (n=7), cutaneous (n=6), pulmonary (n=2), and peripheral nervous system (n=1) domains due to post-vaccination SS flares. In terms of vaccination efficacy, breakthrough SARS-CoV-2 infection was confirmed after vaccination in three (0.24 %) patients, and positive anti-SARS-Cov-2 antibodies were detected in approximately 95% of vaccinated SS patients, according to data available. CONCLUSIONS: Our data suggest that patients with pSS develop adequate humoral response and no severe AEs after SARS-CoV-2 vaccination and therefore raise no concerns about the vaccine's efficacy or safety profile in this population.

Evaluation of Waste Related to the Admission Process of Low-Complexity Patients in Emergency Services, in Light of the Lean Healthcare Philosophy.

The adequacy of work processes in healthcare services contributes to the quality of care provided to the patient. However, in emergency units, overcrowding is a constant reality, resulting in the lack of materials and long waiting lines. Taking this into consideration, this study aimed to map and analyze the value stream of patients classified as blue, green, or yellow in a Referral Emergency Unit. The evaluation research with analysis of processes was carried out in a teaching hospital on 30 patients seen at the emergency service. Value Stream Maps were drawn and the times involved in the process were calculated. Wastes and their possible causes were identified. A total of 13 maps were created and the mean process time between the activities involved in the process ranged between 7.3' and 114.0'; the interruption time, between 0' and 27.6'; the waiting time, between 43.2' and 507.5'; and the lead time between 56.6' and 638.0' min. Some causes of waste were: high demand from patients; a shortage of personnel and offices. Following the Ishikawa Diagram, most of the waste is found regarding methods, human resources, and physical structure.

Lean Healthcare Tools for Processes Evaluation: An Integrative Review.

Several health services have used lean healthcare to seek continuous improvement of their processes. Therefore, it is important to investigate the evidence available in the literature about the most used lean tools in the health area to review processes and the main results achieved by the researchers. As an integrative literature review methodology was used, it was conducted in five databases, using the descriptor "quality improvement" and the keyword "Lean Healthcare". A total of 33 complete articles were selected for analysis. The most recurrent tools were: define, measure, analyze, improve and control (DMAIC); value stream map (VSM); suppliers, inputs, process, outputs, customers analysis (SIPOC), Ishikawa Diagram and 5S. Through the analysis of waste, different interventions were implemented and the main results achieved were reduction in times (processing, waiting, cycle and total), costs, workload and increase in the number of calls. The findings enabled the identification of the main lean tools used in the health area to achieve better results. In particular, we highlight recent studies that have explored the lean six sigma healthcare approach. The results, in addition to contributing to the literature, will also assist managers in choosing the best tool to achieve continuous improvement in hospitals and other health services.

Longitudinalidade na atenção primária à saúde: revisão integrativa da literatura / Longitudinality in primary health care: an integrative literature review / Longitudinalidad en la atención primaria a la salud: revisión integrativa de la literatura

Objetivo: analisar a produção científica que descreve a longitudinalidade na Atenção Primária à Saúde e verificar como ocorre nos serviços. Método: revisão integrativa da literatura de estudos que tratam sobre a longitudinalidade do cuidado nos serviços. Foram utilizadas as bases de dados Literatura Latino-America e Caribe em Ciências da Saúde, Public MEDLINE, SciVerseScopus e no Portal Regional da Biblioteca Virtual em Saúde utilizando os termos: "Primary Health Care", "Longitudinality" e "Public Health". Resultados: 18 artigos, os quais foram categorizados pela sua similaridade nos temas: estudos sobre os atributos da APS, participação dos usuários na efetivação da longitudinalidade e longitudinalidade no cuidado à criança. Conclusão: a confiança mútua entre profissionais e usuários, a continuidade da atenção, a escuta, a credibilidade e a vinculação do usuário com os profissionais configuram a longitudinalidade nos serviços de saúde

Objective:To analyze the scientific production that describes longitudinality in Primary Health Care and to verify how it occurs in the services. Method: integrative review of the literature of studies that deal with the longitudinality of care in services. The Latin American and Caribbean Literature in Health Sciences, Public Medline, SciVerseScopus and the Regional Portal of the Virtual Health Library were used using the terms "Primary Health Care", "Longitudinality" and "Public Health". Results: 18 articles, which were categorized by their similarity in the themes: studies on the attributes of APS, participation of users in the effectiveness of longitudinality and longitudinality in child care. Conclusion: mutual trust between professionals and users, continuity of attention, listening, credibility and the link between the user and the professionals configures longitudinality in health services

Objetivo: Analizar la producción científica que describe la longitudinalidad en la Atención Primaria a la Salud y verificar cómo ocurre en los servicios. Método: revisión integrativa de la literatura de estudios que tratan sobre la longitudinalidad del cuidado en los servicios. Se utilizaron las bases de datos Literatura Latinoamérica y Caribe en Ciencias de la Salud, Public Medline, SciVerseScopus y en el Portal Regional de la Biblioteca Virtual en Salud utilizando los términos: "Primary Health Care", "Longitudinality" y "Public Health". Resultados: 18 artículos, los cuales fueron categorizados por su similitud en los temas: estudios sobre los atributos de la APS, par-ticipación de los usuarios en la efectividad de la longitudinalidad y longitudinalidad en el cuidado al niño. Conclusión: la confianza mutua entre profesionales y usuarios, la continuidad de la atención, la escucha, la credibilidad y la vinculación del usuario con los profesionales configuran la longitudinalidad en los servicios de salud