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1.
J Adv Nurs ; 2023 Nov 27.
Artículo en Inglés | MEDLINE | ID: mdl-38012833

RESUMEN

AIMS: To explore the impact of COVID-19 on students' lives and their online learning experience. DESIGN: A cross-sectional survey design was used in this study. METHODS: A total of 44 nursing students who were enrolled in an undergraduate programme at a Canadian University participated in the study. The students were asked to fill out a 35-item survey that was developed by the European Students' Union and that was circulated across Europe in April 2020. RESULTS: The COVID-19 pandemic and subsequent lockdown affected students mentally, and emotionally. Findings also revealed that whilst most students had the privilege to study from home, many students did not have a desk, or a quiet place to study in their home and some had problems with Internet connectivity. Online lectures were delivered according to students' preferences; however, students were dissatisfied with the way their practice was organized. CONCLUSION: The similarities between this study and the European study provide common grounds for academics around the world to connect, collaborate and work on the challenges in providing nurse education in emergencies such as national disasters or pandemics to ensure preparedness for such future events. PATIENT OR PUBLIC CONTRIBUTION: No Patient or Public Contribution. IMPACT: The commonalities experienced in nursing education across the globe should act as an impetus for globalized nursing action. Educators need to prepare and reinvent a role for students in the clinical area in the event of future disasters/pandemics. Policy makers and administrators need to ensure when switching to online education no student is underprivileged or marginalized in the process.

2.
J Soc Pers Relat ; 40(2): 551-575, 2023 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-38603320

RESUMEN

The aim of this study was to examine workers' psychological distress during the COVID-19 pandemic as a function of their individual coping, dyadic coping, and work-family conflict. We also tested the moderating role of gender and culture in these associations. To achieve this aim, we run HLM analyses on data from 1521 workers cohabiting with a partner, coming from six countries (Italy, Spain, Malta, Cyprus, Greece, and Russia) characterized by various degrees of country-level individualism/collectivism. Across all six countries, findings highlighted that work-family conflict as well as the individual coping strategy social support seeking were associated with higher psychological distress for workers, while the individual coping strategy positive attitude and common dyadic coping were found to be protective against workers' psychological distress. This latter association, moreover, was stronger in more individualistic countries.

3.
BMC Nephrol ; 21(1): 537, 2020 12 10.
Artículo en Inglés | MEDLINE | ID: mdl-33302894

RESUMEN

BACKGROUND: Illness perceptions have been shown to predict a range of psychosocial and clinical outcomes in kidney disease; including quality of life, distress, treatment adherence and even survival in end-stage renal disease patients on dialysis. The aim of this study was to evaluate whether illness perceptions impact mortality in incident predialysis Chronic Kidney Disease (CKD) patients. METHODS: Over the study period between September 2015 and June 2019, a total of 200 participants with predialysis CKD were recruited from the Nephrology Outpatient's clinics at Mater Dei Hospital, Malta. The participants were followed up until June 2019, and the mortality information was collected. Cox proportional hazards models were used to examine the association between illness perceptions, and mortality risk, after adjustment for covariates including distress, kidney function, co-morbidity and psychological distress. RESULTS: Of the 200 cases available for analysis, there were 43 deaths. The mean survival time was 718.55 days (min. 3 days, max. 1297 days). The cumulative survival 1-year post the assessment of the Revised Illness Perceptions Questionnaire (IPQ-R) was 93%. Stronger identity beliefs (HR = 1.199, 95% CI: 1.060-1.357, p = 0.004), perceptions of a chronic timeline (HR = 1.065, 95% CI: 1.003-1.132, p = 0.041), personal control beliefs (HR = 0.845, 95% CI: 0.748-0.955, p = 0.007) and perceptions of control over the treatment (HR = 0.812, 95% CI: 0.725-0.909, p = 0.000) demonstrated a significant association with mortality after controlling covariates. In a subsequent saturated model, perceived identity, chronic timeline and treatment control perceptions remained significant predictors of mortality, together with serum albumin, comorbidities and urea. CONCLUSIONS: CKD patients' perceptions of treatment control, perceptions of a chronic timeline and perceived illness identity predict survival independently of clinical prognostic factors, including kidney function and co-morbidity. Illness perceptions are important and potentially modifiable risk factors in CKD. Further studies are required to test whether the assessment and the implementation of psychological interventions aimed to modify maladaptive illness perceptions influence clinical outcomes in CKD.


Asunto(s)
Actitud Frente a la Salud , Mortalidad , Distrés Psicológico , Insuficiencia Renal Crónica/mortalidad , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Modelos de Riesgos Proporcionales , Insuficiencia Renal Crónica/fisiopatología , Insuficiencia Renal Crónica/psicología
4.
Undersea Hyperb Med ; 47(1): 39-50, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32176945

RESUMEN

Hyperbaric medicine is a relatively young specialty that remains in the blind spot of most doctors' awareness. This study endeavors to identify the level of awareness of the indications for hyperbaric oxygen (HBO2) therapy among a doctor population in a developed country and factors which may improve referral rates. An anonymized questionnaire was distributed to doctors licensed to practice in Malta. Questions included physician specialty, demographics and previous exposure to diving and/or hyperbaric medicine. Moreover, two scoring systems were used to score subjects on HBO2-related topics. Binomial logistic regression models and generalized linear models were used in the statistical analysis. A total of 152 full replies were obtained and analyzed. Respondents who had visited a hyperbaric unit (HBU) (p=0.002) or attended a lecture on HBO2 (p=0.006) scored better than their counterparts, indicating better awareness of HBO2 indications and local chamber location. A previous HBU visit (p=0.001), being a hospital-based doctor (p=0.027) and a history of scuba diving (p=0.03) were associated with willingness to refer patients for HBO2 in the future. Encouraging visits to an HBU has been shown to be associated with multiple factors, which are expected to result in improved referral rates. Targeted educational sessions to doctors and medical students are likely to be beneficial in improving correct referral of patients for HBO2. The findings from this study may prove useful in improving appropriate referral rates of patients who may benefit from this useful treatment modality.


Asunto(s)
Conocimientos, Actitudes y Práctica en Salud , Oxigenoterapia Hiperbárica/estadística & datos numéricos , Médicos/estadística & datos numéricos , Derivación y Consulta/estadística & datos numéricos , Encuestas y Cuestionarios/estadística & datos numéricos , Adulto , Actitud del Personal de Salud , Femenino , Humanos , Modelos Logísticos , Masculino , Malta
5.
J Antimicrob Chemother ; 74(11): 3379-3383, 2019 11 01.
Artículo en Inglés | MEDLINE | ID: mdl-31314092

RESUMEN

OBJECTIVES: Sociocultural factors have been hypothesized as important drivers of inappropriate antibiotic prescribing in European ambulatory care. This study sought to assess whether they can also explain the reported variation in broad-spectrum antibiotic (Br-Ab) use among EU/European Economic Area (EEA) countries. METHODS: Correlation and regression analysis were performed, using the bootstrap method, between Br-Ab ratios reported from 28 EU countries by the ECDC, and national Hofstede cultural dimensions and control of corruption (CoC) scores. RESULTS: Significant bootstrapping correlation coefficients were identified between Br-Ab ratios and the dimension of uncertainty avoidance (UAI) as well as CoC. However, following both bootstrapping multiple regression and generalized linear modelling, only UAI was retained as the sole predictor. A logarithmic model explained 58.6% of the variation in European Br-Ab variability solely using national UAI scores (P < 0.001). CONCLUSIONS: Br-Ab prescribing appears to be driven by the level of UAI within the country. Any interventions aimed at reducing Br-Ab in high-consuming EU/EEA countries need to address this cultural perception to maximize their chances of success.


Asunto(s)
Antibacterianos/uso terapéutico , Características Culturales , Conocimientos, Actitudes y Práctica en Salud , Pautas de la Práctica en Medicina/estadística & datos numéricos , Atención Ambulatoria/estadística & datos numéricos , Europa (Continente) , Unión Europea , Humanos
6.
Qual Life Res ; 28(2): 451-460, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30244359

RESUMEN

PURPOSE: To examine the illness perceptions of informal carers of persons with depression, using the theoretical framework of Leventhal's Common-Sense Model (CSM) and to determine whether these illness perceptions are predictors of anxiety and depression, as measures of psychological well-being. METHODS: A cross-sectional survey was conducted with 94 Maltese individuals caring for a person with depression within a community setting. The informal carers completed the modified Illness Perception Questionnaire (IPQS-Relatives version) and the Hospital Anxiety and Depression Scale (HADS). Data were analysed using descriptive statistics, Spearman's rank order correlations and ANCOVA regression models, to identify predictors of anxiety and depression respectively in the informal carers. RESULTS: The informal carers perceived depression as a cyclical condition, having negative consequences on both the patient and on themselves. Participants perceived the causes of depression to be mainly psychosocial in nature and generally viewed the treatment as effective. Caring for a person with depression was perceived as having a considerable negative emotional impact on them. Years of caring was identified as a predictor of anxiety accounting for 20.4% of the variance, and timeline chronicity beliefs, consequences (relative) and illness coherence were identified as predictors of depression, accounting for 56.8% of the variance. CONCLUSION: Illness cognitions are significant predictors of depression, thereby suggesting that cognition-based interventions may be effective in targeting depression in these informal carers. Thus, health professionals should explore the carers' personal understanding of the disease, their timeline beliefs and the perceived consequences of providing care, as they relate to their psychological well-being.


Asunto(s)
Ansiedad/psicología , Cuidadores/psicología , Depresión/psicología , Calidad de Vida/psicología , Adulto , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Percepción , Encuestas y Cuestionarios
7.
J Theor Biol ; 450: 37-42, 2018 08 07.
Artículo en Inglés | MEDLINE | ID: mdl-29705490

RESUMEN

We introduce a mathematical model that describes the allometry of physical characteristics of hollow organs behaving as pressure vessels based on the physics of ideal pressure vessels. The model was validated by studying parameters such as body and organ mass, systolic and diastolic pressures, internal and external dimensions, pressurization energy and organ energy output measurements of pressure-based organs in a wide range of mammals and birds. Seven rules were derived that govern amongst others, lack of size efficiency on scaling to larger organ sizes, matching organ size in the same species, equal relative efficiency in pressurization energy across species and direct size matching between organ mass and mass of contents. The lung, heart and bladder follow these predicted theoretical relationships with a similar relative efficiency across various mammalian and avian species; an exception is cardiac output in mammals with a mass exceeding 10 kg. This may limit massive body size in mammals, breaking Cope's rule that populations evolve to increase in body size over time. Such a limit was not found in large flightless birds exceeding 100 kg, leading to speculation about unlimited dinosaur size should dinosaurs carry avian-like cardiac characteristics.


Asunto(s)
Estructuras Animales/fisiología , Modelos Teóricos , Presión , Estructuras Animales/anatomía & histología , Animales , Aves/anatomía & histología , Tamaño Corporal , Dinosaurios/anatomía & histología , Modelos Biológicos , Tamaño de los Órganos
8.
J Prosthodont ; 27(2): 115-119, 2018 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-27244551

RESUMEN

PURPOSE: To investigate the surface microstructural changes and the release of ions from metal alloys used in removable dental prostheses and the potential effects of acidic reflux found in patients suffering from gastroesophageal reflux disease (GERD). MATERIALS AND METHODS: Thirty-seven (37) patients were recruited. Data were gathered through a questionnaire and clinical examination. Samples of metal alloy from the dentures and patient's saliva were collected. GERD was confirmed using the GerdQ questionnaire. Denture samples were characterized using scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS), while salivary samples were tested for trace metal ions using inductively coupled plasma (ICP). RESULTS: Characterization of denture samples revealed the presence of nickel, cobalt, and chromium. Nickel-chromium exhibited an etched surface appearance, while cobalt-chromium exhibited no noticeable surface microstructural changes. Higher mean salivary levels of chromium and cobalt in patients wearing any metal alloy-based denture and of chromium and nickel in patients wearing Ni-Cr prostheses were found to be significant. No differences were found in salivary metal ion levels of patients suffering from GERD. CONCLUSIONS: Nickel-chromium alloy is prone to acid etching in the oral cavity, while cobalt-chromium alloy appears to be more resistant. Cobalt, chromium, and nickel are leached in saliva of patients using cast removable prostheses. The impact of gastric acid on metal ion release from dental metal alloys deserves further investigations. CLINICAL SIGNIFICANCE: This preliminary study suggests that metal-based removable prostheses leach trace metal ions in saliva. Nickel-chromium-based dentures exhibit an etched appearance unrelated to GERD.


Asunto(s)
Aleaciones de Cromo/efectos adversos , Dentadura Parcial Removible/efectos adversos , Reflujo Gastroesofágico/complicaciones , Estudios de Casos y Controles , Cromo/análisis , Cobalto/análisis , Estudios Transversales , Humanos , Microscopía Electrónica de Rastreo , Níquel/análisis , Saliva/química , Espectrometría por Rayos X , Encuestas y Cuestionarios , Factores de Tiempo
9.
J Prosthodont ; 27(5): 461-468, 2018 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-27244668

RESUMEN

PURPOSE: Dental prosthetic and orthodontic appliances are transported from the clinic to the laboratory for additions and repairs. These appliances, containing microbes from the oral flora, are a high risk for cross-contamination. The aim of this study was to evaluate the effect of chemical and ultrasound disinfection against two in vitro biofilms and an in vivo formed biofilm grown on unprepared and polished polymethyl methacrylate (PMMA) surfaces. MATERIALS AND METHODS: Rough and polished self-curing PMMA surfaces were infected with strains of both Candida albicans and Streptococcus oralis. After incubation, the samples were treated with different disinfection methods, including ultrasound treatment for both 15 and 30 seconds, and immersion in glutaraldehyde and alcohol-based chemical disinfectants (MD520 and Minuten, respectively). The disinfecting efficacy was assessed by colony forming units (CFU) analysis and by scanning electron microscopy (SEM). Furthermore the adequacy of bacterial elimination of application of 30-second ultrasound and MD520 was assessed on PMMA retrieved from ten volunteers by CFU analyses. ANOVA with p = 0.05 followed by the Tukey post hoc test and the Student t-test was used to analyze the data. RESULTS: The ultrasound treatment for 30 seconds, MD520, and Minuten were the most effective disinfectant methods as they reduced the microbial counts compared to the control (p < 0.05) as shown in the in vitro analyses. S. oralis adhered more to rough acrylic resin surfaces (p < 0.05). Ultrasound treatment was the most effective way to reduce microbial counts on PMMA exposed to oral flora (p = 0.043). CONCLUSION: Ultrasound treatment for 30 seconds was effective against C. albicans, S. oralis, and the oral flora as shown by testing microbial growth on agar plates and SEM.


Asunto(s)
Resinas Acrílicas/química , Biopelículas/efectos de los fármacos , Desinfectantes Dentales/farmacología , Materiales Dentales/química , Desinfección/métodos , Contaminación de Equipos/prevención & control , Glutaral/farmacología , Polimetil Metacrilato/química , Ultrasonido , Candida albicans , Recuento de Colonia Microbiana , Humanos , Microscopía Electrónica de Rastreo , Streptococcus oralis , Propiedades de Superficie
10.
Postgrad Med J ; 93(1104): 607-612, 2017 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-28490545

RESUMEN

INTRODUCTION: Red blood cell distribution width (RDW) is a novel independent marker of cardiovascular disease including heart failure, coronary artery disease and myocardial ischaemia. The aim of the study was to investigate a possible relationship between RDW and myocardial scar burden, as assessed by a MIBI viability scan. A secondary objective was to assess whether there is an association between RDW and left ventricular ejection fraction (LVEF). METHODS: The study comprised 123 subjects with ischaemic heart disease who underwent a myocardial viability scan between June 2008 and July 2014. Haemoglobin, mean corpuscular volume, RDW, platelet count, mean platelet volume (MPV), estimated glomerular filtration rate, fasting blood glucose, liver and lipid profiles were evaluated for all patients. The extent of myocardial scarring and LVEF were noted. Data were analysed using IBM SPSS Statistics 22.0. Univariate followed by multivariate analyses were performed to assess for independent predictors of myocardial scarring and LVEF, respectively. RESULTS: The mean age of the study population was 63.5 years; most of the subjects were men. The median LVEF was 31% and median percentage of myocardial scarring was 8.7%. Multivariate analyses revealed that RDW, HDL-cholesterol and alanine transaminase were independent predictors of myocardial scarring while RDW, MPV, LDL-cholesterol and gamma-glutamyl transpeptidase were independent predictors of LVEF. CONCLUSIONS: Increased RDW is an independent predictor both of myocardial scar burden and of impaired left ventricular function in subjects with coronary artery disease.


Asunto(s)
Cicatriz/patología , Enfermedad Coronaria/sangre , Enfermedad Coronaria/patología , Biomarcadores/sangre , Glucemia/análisis , Enfermedad Coronaria/diagnóstico por imagen , Índices de Eritrocitos , Femenino , Tasa de Filtración Glomerular , Humanos , Lípidos/sangre , Pruebas de Función Hepática , Masculino , Malta , Persona de Mediana Edad , Imagen de Perfusión , Valor Predictivo de las Pruebas , Radiofármacos , Tecnecio Tc 99m Sestamibi , Disfunción Ventricular Izquierda/sangre , Disfunción Ventricular Izquierda/diagnóstico por imagen , Disfunción Ventricular Izquierda/patología
11.
J Clin Nurs ; 26(15-16): 2426-2438, 2017 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-27571315

RESUMEN

AIMS AND OBJECTIVES: To examine the association between sociodemographic, pregnancy-related variables and psychological and verbal intimate partner abuse, as well as to determine which of these variables are predictors of psychological and verbal intimate partner abuse during pregnancy. BACKGROUND: Intimate partner violence is a significant health issue, with severe implications to both mother and foetus. However, much of the research to date focuses on the outcomes of physical abuse. This article addresses the dearth in the literature by examining the association between sociodemographic, pregnancy-related variables and psychological and verbal intimate partner abuse during pregnancy. DESIGN: A survey research design was used. METHOD: Three hundred postnatal women were recruited by convenience, nonproportional quota sampling technique. The WHO Violence Against Women Instrument was self-administered by participants. The association between categorical variables was assessed using Pearson's chi-square test, the strength of association using Cramer's V and the phi coefficient, and the identification of predictor variables for psychological and verbal abuse using logistic regression analysis. RESULTS: Four predictors were identified for psychological abuse, namely low education level in women, an unplanned pregnancy, experiencing two or more pregnancy-related health problems and living with an unemployed partner. However, unemployment in women, an unplanned pregnancy, fear of partner and a low education level of partner were identified as the predictors of verbal abuse. CONCLUSION: This study identified a number of variables that strongly predict psychological and verbal intimate partner abuse during pregnancy; however, it extends the available literature by identifying a low standard of education in males, unemployment and fear of the intimate partner as the significant predictors of psychological and verbal intimate partner abuse. RELEVANCE TO CLINICAL PRACTICE: Healthcare professionals should be aware of the predictors predisposing pregnant women to abuse. This would enable the identification of pregnant women who are susceptible to psychological and verbal intimate partner abuse, thus enabling the provision of adequate support. There is also a need to introduce routine screening for psychological and verbal intimate partner abuse during the antenatal period, following extensive training to all professionals concerned.


Asunto(s)
Mujeres Maltratadas/psicología , Violencia de Pareja/psicología , Atención Perinatal , Complicaciones del Embarazo/psicología , Adolescente , Adulto , Femenino , Humanos , Relaciones Interpersonales , Masculino , Malta , Servicios de Salud Materna , Embarazo , Complicaciones del Embarazo/enfermería , Encuestas y Cuestionarios , Adulto Joven
12.
Chron Respir Dis ; 14(4): 352-359, 2017 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-29081264

RESUMEN

The St. George's Respiratory Questionnaire (SGRQ) and chronic obstructive pulmonary disease (COPD) assessment test (CAT) are the measures used to assess health status. This study aims to examine the responsiveness of these tools by severity of dyspnoea category in patients with COPD. Forty-nine COPD patients who underwent a 12-week pulmonary rehabilitation (PR) programme were assessed at baseline, 12 weeks and at 28-week follow-up. Patients were categorized into two groups by severity of dyspnoea category (i.e. mild to moderate (modified Medical Research Council (mMRC) 1-2) and severe to very severe (mMRC 3-4)) using the mMRC dyspnoea scale. Effect size (ES) was computed as estimates of responsiveness. The SGRQ demonstrated greater responsiveness by total sample (SGRQ, ES = 0.87; CAT, ES = 0.75) and for the mMRC 3-4 category (SGRQ, ES = 0.91; CAT, ES = 0.76) on completion of PR. At 28-week follow-up, overall comparable responsiveness of the CAT and SGRQ was identified by total sample (SGRQ, ES = 0.75; CAT, ES = 0.74) and by severity of dyspnoea category. The symptom, impact and activity domains of the SGRQ showed good responsiveness, with greater ESs obtained overall for the mMRC 3-4 category. On completion of PR, the SGRQ demonstrates a greater responsiveness with COPD patients, especially in relation to the mMRC 3-4 category, while both the CAT and SGRQ show comparable responsiveness on follow-up.


Asunto(s)
Disnea/etiología , Estado de Salud , Enfermedad Pulmonar Obstructiva Crónica/rehabilitación , Encuestas y Cuestionarios , Anciano , Ergometría , Femenino , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Enfermedad Pulmonar Obstructiva Crónica/complicaciones , Índice de Severidad de la Enfermedad , Evaluación de Síntomas , Prueba de Paso
13.
Clin Anat ; 28(8): 1008-16, 2015 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-26297570

RESUMEN

The human rib cage resembles a masonry dome in shape. Masonry domes have a particular construction that mimics stress distribution. Rib cortical thickness and bone density were analyzed to determine whether the morphology of the rib cage is sufficiently similar to a shell dome for internal rib structure to be predicted mathematically. A finite element analysis (FEA) simulation was used to measure stresses on the internal and external surfaces of a chest-shaped dome. Inner and outer rib cortical thickness and bone density were measured in the mid-axillary lines of seven cadaveric rib cages using computerized tomography scanning. Paired t tests and Pearson correlation were used to relate cortical thickness and bone density to stress. FEA modeling showed that the stress was 82% higher on the internal than the external surface, with a gradual decrease in internal and external wall stresses from the base to the apex. The inner cortex was more radio-dense, P < 0.001, and thicker, P < 0.001, than the outer cortex. Inner cortical thickness was related to internal stress, r = 0.94, P < 0.001, inner cortical bone density to internal stress, r = 0.87, P = 0.003, and outer cortical thickness to external stress, r = 0.65, P = 0.035. Mathematical models were developed relating internal and external cortical thicknesses and bone densities to rib level. The internal anatomical features of ribs, including the inner and outer cortical thicknesses and bone densities, are similar to the stress distribution in dome-shaped structures modeled using FEA computer simulations of a thick-walled dome pressure vessel. Fixation of rib fractures should include the stronger internal cortex.


Asunto(s)
Modelos Teóricos , Costillas/anatomía & histología , Pared Torácica/anatomía & histología , Densidad Ósea , Cadáver , Análisis de Elementos Finitos , Humanos , Fracturas de las Costillas/patología , Costillas/diagnóstico por imagen , Estrés Mecánico , Pared Torácica/diagnóstico por imagen , Tomografía por Rayos X
14.
Clin Anat ; 28(5): 614-20, 2015 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-25851916

RESUMEN

This study was aimed at determining the cause for the high incidence of tuberculosis (TB) reactivation occurring in males with a low body mass index (BMI). Current thinking about pulmonary TB describes infection in the lung apex resulting in cavitation after reactivation. A different hypothesis is put forward for TB infection, suggesting that this occurs in subclinical apical cavities caused by increased pleural stress due to a low BMI body habitus. A finite element analysis (FEA) model of a lung was constructed including indentations for the first rib guided by paramedian sagittal CT reconstructions, and simulations were conducted with varying antero-posterior (AP) diameters to mimic chests with a different thoracic index (ratio of AP to the transverse chest diameters). A Pubmed search was conducted about gender and thoracic index, and the effects of BMI on TB. FEA modeling revealed a tenfold increase in stress levels at the lung apex in low BMI chests, and a four-fold increase with a low thoracic index, r(2) = 0.9748 P < 0.001. Low thoracic index was related to BMI, P = 0.001. The mean thoracic index was statistically significantly lower in males, P = 0.001, and increased with age in both genders. This article is the first to suggest a possible mechanism linking pulmonary TB reactivation to low BMI due to the flattened thoracic wall shape of young male adults. The low thoracic index in young males may promote TB reactivation due to tissue destruction in the lung apex from high pleural stress levels.


Asunto(s)
Pared Torácica/anatomía & histología , Tuberculosis Pulmonar/epidemiología , Índice de Masa Corporal , Femenino , Análisis de Elementos Finitos , Humanos , Incidencia , Masculino , Modelos Anatómicos , Radiografía Torácica/métodos , Recurrencia , Factores Sexuales , Pared Torácica/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Adulto Joven
15.
Clin Anat ; 28(4): 512-9, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-25716367

RESUMEN

As ribs adapt to stress like all bones, and the chest behaves as a pressure vessel, the effect of stress on the ribs can be determined by measuring rib height and thickness. Rib height and thickness (depth) were measured using CT scans of seven rib cages from anonymized cadavers. A Finite Element Analysis (FEA) model of a rib cage was constructed using a validated approach and used to calculate intramuscular forces as the vectors of both circumferential and axial chest wall forces at right angles to the ribs. Nonlinear quadratic models were used to relate rib height and rib thickness to rib level, and intercostal muscle force to vector stress. Intercostal muscle force was also related to vector stress using Pearson correlation. For comparison, rib height and thickness were measured on CT scans of children. Rib height increased with rib level, increasing by 13% between the 3rd and 7th rib levels, where the 7th/8th rib was the widest part or "equator" of the rib cage, P < 0.001 (t-test). Rib thickness showed a statistically significant 23% increase between the 3rd and 7th ribs, P = 0.004 (t-test). Intercostal muscle force was significantly related to vector stress, Pearson correlation r = 0.944, P = 0.005. The three nonlinear quadratic models developed all had statistically significant parameter estimates with P < 0.03. External rib morphology, in particular rib height and thickness, can be predicted using statistical mathematical models. Rib height is significantly related to the calculated intercostal muscle force, showing that environmental factors affect external rib morphology.


Asunto(s)
Músculos Intercostales/fisiología , Modelos Biológicos , Costillas/anatomía & histología , Costillas/fisiología , Análisis de Elementos Finitos , Humanos , Imagenología Tridimensional , Radiografía , Fracturas de las Costillas/etiología , Costillas/diagnóstico por imagen , Estrés Mecánico
16.
Thromb Res ; 235: 41-51, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-38295600

RESUMEN

BACKGROUND: Several generic formulations of rivaroxaban were recently marketed to be used interchangeably with their branded equivalent. However, there have been no previously published studies that directly compared the in vitro anticoagulant effect of branded vs. generic rivaroxaban. The aim of this in vitro study was to compare the effects of three raw rivaroxaban materials, obtained from the branded (Xarelto®) and two generic (Rivarolto® and Rivaroxaban Sandoz®) rivaroxaban formulations on an array of coagulation assays. METHODS: A pool of normal plasma was spiked with several concentrations of the three rivaroxaban (range 50-750 ng/ml). The concentrations were assessed with a rivaroxaban calibrated anti-Xa assay and confirmed by ultra-high-performance liquid chromatography-mass spectrometry coupled with tandem mass spectrometry (UHPLC-MS/MS). The following assays were performed: Prothrombin time (PT), activated Partial Thromboplastin time (aPTT), Diluted Russell's Viper Venom Test (dRVVT), Thrombin time (TT), Clauss Fibrinogen, Factor VII, VIII and IX assays, and thromboelastography. RESULTS: The results obtained by the three rivaroxaban at similar concentrations were comparable. Increasing concentrations of the three rivaroxaban showed a strong positive correlation with the PT, aPTT and dRVVT assays (r > 0.95, p < 0.01 for all), and a strong negative correlation with the Factors assays (r < -0.95, p < 0.01 for all). TT and Clauss Fibrinogen were not affected by rivaroxaban. No significant difference was identified in the mean assays' results obtained by the three rivaroxaban. CONCLUSION: This study showed that the branded and generic rivaroxaban exert an identical in vitro anticoagulant effect across a wide range of concentrations.


Asunto(s)
Hemostáticos , Rivaroxabán , Humanos , Rivaroxabán/farmacología , Rivaroxabán/uso terapéutico , Espectrometría de Masas en Tándem , Proyectos de Investigación , Fibrinógeno , Anticoagulantes/farmacología , Anticoagulantes/uso terapéutico
17.
Front Psychol ; 14: 1214518, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37599743

RESUMEN

Background: Although parental checklists are well-known for their potential in indexing young children's lexicon size, they can also be used to track children's acquisition of individual words. Word-level data can be used to identify the checklist words most and least commonly employed across groups of children. Like parent-completed vocabulary checklists, samples of spontaneous language use collected from multiple children can also generate measures of word commonality, concerned with the numbers of children producing individual words. To our knowledge, comparisons of word usage as determined by parental checklist and language sample data obtained in parallel from the same children have not been carried out. Also scarce in the empirical literature are item-level analyses of early bilingual lexicons that explore word usage across two emerging languages. The present study aimed to contribute toward bridging both gaps through the analysis of data generated by a bilingual Maltese-English adaptation of the vocabulary checklist of the MacArthur Communicative Development Inventories: Words and Sentences (CDI: WS) and spontaneous language samples for the same children. An additional objective was to derive implications for revising the current version of the vocabulary checklist, in preparation for its eventual standardization. Materials and methods: For 44 Maltese children aged 12, 18, 24, and 30 months, the words reported by their main caregivers on the vocabulary checklist were identified, along with their respective semantic categories. For the same children, 20-min language samples obtained during free play with the caregiver were transcribed orthographically. Words identified through parental report and language sampling were analyzed for commonality, i.e., the number of children producing each word. Results: Comparison of the word usage patterns obtained through both methods indicated differences in the words most commonly sampled and those most commonly reported, particularly in relation to grammatical categories. Notwithstanding these differences, positive and significant correlations emerged when considering all grammatical categories and languages across commonality levels. Discussion: The commonality scores based on parental checklist data have implications for reconsidering the length and language balance of the Maltese-English adaptation of the CDI: WS vocabulary checklist. Sampled word usage patterns can contribute additional objectivity in updating the reporting instrument in preparation for its eventual standardization.

18.
J Pharm Pract ; 36(6): 1498-1504, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-35711170

RESUMEN

INTRODUCTION: Interprofessional Education (IPE) activities are a first experience of real-world patient care practice for students, where collaboration with different professions is appreciated. Methods and timing of inclusion of IPE are not well-defined, and it is interesting to assess students' perception on IPE activities. OBJECTIVE: To assess changes in pharmacy students' perception of IPE before (t0) and after (t1) an IPE activity. METHODS: The 'Student Perceptions of Interprofessional Clinical Education-Revised 2' (SPICE-R2) tool was adopted to assess perception of IPE activities in third year pharmacy students, final year pharmacy students and in postgraduate Doctorate in Pharmacy (PharmD) students at t0 and t1. RESULTS: The SPICE-R2 tool was completed at t0 and t1 by 61 students: 12 third year pharmacy students, 13 final year students and 36 PharmD students. A significant improvement between t0 and t1 (P < .05) was measured in the three groups of students for all three subscales of the tool. The largest improvement was observed in the 'Roles/Responsibilities for Collaborative Practice' subscale in all three groups of students. CONCLUSION: Perception of IPE was positively increased in all three student groups. The results could be useful to support the design of IPE activities within pharmacy programmes.


Asunto(s)
Farmacia , Estudiantes de Farmacia , Humanos , Relaciones Interprofesionales , Educación Interprofesional , Percepción , Actitud del Personal de Salud
19.
J Clin Med ; 12(3)2023 Jan 24.
Artículo en Inglés | MEDLINE | ID: mdl-36769567

RESUMEN

(1) Objective: To identify the assessment tools and outcome measures used to assess older adults for inpatient rehabilitation. (2) Design: Scoping review. (3) Data sources: ProQuest, PEDro, PubMed, CINAHL Plus with full text (EBSCO), Cochrane Library and reference lists from included studies. (4) Review method: The inclusion of studies covering patients aged >60, focusing on rehabilitation assessments delivered in hospitals in community settings. Studies reporting on rehabilitation specifically designed for older adults-testing for at least one domain that affects rehabilitation or assessments for admission to inpatient rehabilitation-were also included. Results were described both quantitatively and narratively. (5) Results: 1404 articles were identified through selected databases and registers, and these articles underwent a filtering process intended to identify and remove any duplicates. This process reduced the number to 1186 articles. These, in turn, were screened for inclusion criteria, as a result of which 37 articles were included in the final review. The majority of assessments for geriatric rehabilitation were carried out by a multidisciplinary team. Multiple studies considered more than one domain during assessment, with a high percentage evaluating a specific outcome measure used in geriatric rehabilitation. The most common domains assessed were function, cognition and medical status-with communication, vision and pain being the least common. A total of 172 outcome measures were identified in this review, with MMSE, BI, FIM and CCI being the most frequent. (6) Conclusions: This review highlights the lack of standardised approaches in existing assessment processes. Generally, older-adult-rehabilitation assessments struggle to capture rehabilitation potential in a holistic manner. Hence, a predictive model of rehabilitation for assessing patients at the initial stages would be useful in planning a patient-specific programme aimed at maximising functional independence and, thus, quality of life.

20.
Int J Rehabil Res ; 46(3): 252-257, 2023 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-37067997

RESUMEN

Osteoarthritis is a condition commonly present in the elderly, with many having altered balance, aggravated with weak lower limb and core musculature predisposing them to falls. Despite the knowledge about the link between balance and core stability, studies investigating the importance of core stability exercise and their impact on balance are limited. Therefore, the authors aimed to explore whether core strengthening exercises in combination with hip exercises, when compared to a hip exercise programme and a control group, led to better improvements in balance in patients with hip osteoarthritis. In order to meet these aims, this paper reports the outcomes of a randomized, three-arm parallel, assessor-blinded, controlled clinical trial. Fifty-one participants awaiting a total hip replacement were recruited into this study. All patients were randomly allocated to a control, hip exercise group and hip and core exercise group. All participants were assessed for core muscle strength using a pressure biofeedback unit and balance using the four-stage balance test. The control group had no intervention. A 12-week hip and core exercise programme did not result in improvements over and above the hip exercise group in balance scores. However an improvement in core stability was noted for the hip and core exercise group ( P  = 0.001). Therefore, this study concluded that both exercise groups are resulted in improved balance with the core and hip exercise group noted to have added improvements, but the difference between the groups was not statistically significant.


Asunto(s)
Artroplastia de Reemplazo de Cadera , Osteoartritis de la Cadera , Humanos , Anciano , Terapia por Ejercicio/métodos , Modalidades de Fisioterapia , Ejercicio Físico , Fuerza Muscular/fisiología
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