Asunto(s)
Temblor Esencial/tratamiento farmacológico , Moduladores del GABA/uso terapéutico , Ácido gamma-Aminobutírico/análogos & derivados , Adulto , Estudios Cruzados , Método Doble Ciego , Determinación de Punto Final , Temblor Esencial/fisiopatología , Humanos , Pregabalina , Estudios Prospectivos , Resultado del Tratamiento , Ácido gamma-Aminobutírico/uso terapéuticoRESUMEN
BACKGROUND: Tremors may be difficult to classify. CASE REPORT: An 83-year-old male presented with an unusual left wrist tremor. The tremor could be reproducibly elicited by making a fist or carrying a weighted object (e.g., a shopping bag, bottle of water) of approximately 1â lb or more, and it intensified with heavier weights. The tremor was difficult to classify, although it shared features with isometric tremor. DISCUSSION: This specific presentation of tremor has not been reported previously. We hope that the detailed description we provide will aid other neurologists who encounter this or similar tremors in their clinics.
RESUMEN
Essential tremor (ET) is one of the most common tremor disorders in the world. Despite this, only two medications have received Level A recommendations from the American Academy of Neurology to treat it (primidone and propranolol). Even though these medications provide relief to a large group of ET patients, up to 50% of patients are non-responders. Additional medications to treat ET are needed. This review discusses some of the methodological issues that should be addressed for quality clinical drug development in ET.