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J Infect Dis ; 229(1): 39-42, 2024 Jan 12.
Artículo en Inglés | MEDLINE | ID: mdl-37368349

RESUMEN

This was a follow-up study conducted in 2020 assessing changes in levels of type 2 poliovirus-neutralizing antibodies 2 years postimmunization in children who received inactivated poliovirus vaccine (IPV) in Karachi, Pakistan. Unexpectedly, the findings revealed an increase in seroprevalence of type 2 antibodies from 73.1% to 81.6% 1 year and 2 years after IPV, respectively. The increase in type 2 immunity could result from the intensive transmission of circulating vaccine-derived poliovirus type 2 (cVDPV2) in Karachi during the second year of IPV administration. This study suggests that the cVDPV2 outbreak detected in Pakistan infected large proportions of children in Karachi. Clinical Trials Registration . NCT03286803.


Asunto(s)
Poliomielitis , Poliovirus , Niño , Humanos , Anticuerpos Antivirales , Estudios de Seguimiento , Pakistán/epidemiología , Vacuna Antipolio de Virus Inactivados , Vacuna Antipolio Oral , Estudios Seroepidemiológicos
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