High-performance 3D waveguide architecture for astronomical pupil-remapping interferometry.

The detection and characterization of extra-solar planets is a major theme driving modern astronomy. Direct imaging of exoplanets allows access to a parameter space complementary to other detection methods, and potentially the characterization of exoplanetary atmospheres and surfaces. However achieving the required levels of performance with direct imaging from ground-based telescopes (subject to Earth's turbulent atmosphere) has been extremely challenging. Here we demonstrate a new generation of photonic pupil-remapping devices which build upon the Dragonfly instrument, a high contrast waveguide-based interferometer. This new generation overcomes problems caused by interference from unguided light and low throughput. Closure phase measurement scatter of only ∼ 0.2° has been achieved, with waveguide throughputs of > 70%. This translates to a maximum contrast-ratio sensitivity between star and planet at 1λ/D (1σ detection) of 5.3 × 10(-4) (with a conventional adaptive-optics system) or 1.8 × 10(-4) (with 'extreme-AO'), improving even further when random error is minimized by averaging over multiple exposures. This is an order of magnitude beyond conventional pupil-segmenting interferometry techniques (such as aperture masking), allowing a previously inaccessible part of the star to planet contrast-separation parameter space to be explored.

Effect of formalin fixation on biexponential modeling of diffusion decay in prostate tissue.

PURPOSE: To evaluate the effect of formalin fixation on biexponential modeling of diffusion decay in prostate tissue. METHODS: Three whole prostate specimens were imaged unfixed immediately postsurgery, and again after formalin fixation. Diffusion-weighted imaging was performed over an extended range of b-values and a biexponential model fitted to the signal decay curves. RESULTS: Tissue fixation resulted in a 35%, 20%, and 20% reduction in mean apparent diffusion coefficient of the higher diffusivity fit component for the three organs, respectively, and a 64%, 57%, and 45% reduction in mean apparent diffusion coefficient of the lower diffusivity component. The mean signal fraction of the higher diffusivity component was increased by 23%, 5%, and 1%, respectively. The effect of fixation did not appear to vary according to tissue type or glandular zone. CONCLUSION: Formalin fixed tissue appears to provide a stable model for detailed investigation of the microscopic biophysical basis of diffusion phenomena observed in vivo. Diffusivity changes that result from fixation may provide information about the microscopic environments of the biexponential components.

Low bend loss waveguides enable compact, efficient 3D photonic chips.

We present a novel method to fabricate low bend loss femtosecond-laser written waveguides that exploits the differential thermal stabilities of laser induced refractive index modifications. The technique consists of a two-step process; the first involves fabricating large multimode waveguides, while the second step consists of a thermal post-annealing process, which erases the outer ring of the refractive index profile, enabling single mode operation in the C-band. By using this procedure we report waveguides with sharp bends (down to 16.6 mm radius) and high (80%) normalized throughputs. This procedure was used to fabricate an efficient 3D, photonic device known as a "pupil-remapper" with negligible bend losses for the first time. The process will also allow for complex chips, based on 10's - 100's of waveguides to be realized in a compact foot print with short fabrication times.

Design of optically path-length-matched, three-dimensional photonic circuits comprising uniquely routed waveguides.

A method for designing physically path-length-matched, three-dimensional photonic circuits is described. We focus specifically on the case in which all the waveguides are uniquely routed from the input to output-a problem that has not been addressed to date and that allows for the waveguides to be used in interferometric measurements. Circuit elements were fabricated via the femtosecond laser direct-write technique. We demonstrate via interferometric methods that the fabricated circuits were indeed optically path-length matched to within 45 µm, which is within the coherence length required for many applications.