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1.
J Immunol ; 2024 Jun 26.
Artículo en Inglés | MEDLINE | ID: mdl-38922186

RESUMEN

Neutrophils accumulate early in tissue injury. However, the cellular and functional heterogeneity of neutrophils during homeostasis and in response to tissue damage remains unclear. In this study, we use larval zebrafish to understand neutrophil responses to thermal injury. Single-cell transcriptional mapping of myeloid cells during a 3-d time course in burn and control larvae revealed distinct neutrophil subsets and their cell-cell interactions with macrophages across time and conditions. The trajectory formed by three zebrafish neutrophil subsets resembles human neutrophil maturation, with varying transition patterns between conditions. Through ligand-receptor cell-cell interaction analysis, we found that neutrophils communicate more in burns in a pathway and temporal manner. Finally, we identified the correlation between zebrafish myeloid signatures and human burn severity, establishing GPR84+ neutrophils as a potential marker of early innate immune response in burns. This work builds a comparative single-cell transcriptomic framework to identify neutrophil markers of tissue damage using model organisms.

2.
Hum Brain Mapp ; 45(7): e26691, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38703114

RESUMEN

Verbal memory decline is a significant concern following temporal lobe surgeries in patients with epilepsy, emphasizing the need for precision presurgical verbal memory mapping to optimize functional outcomes. However, the inter-individual variability in functional networks and brain function-structural dissociations pose challenges when relying solely on group-level atlases or anatomical landmarks for surgical guidance. Here, we aimed to develop and validate a personalized functional mapping technique for verbal memory using precision resting-state functional MRI (rs-fMRI) and neurosurgery. A total of 38 patients with refractory epilepsy scheduled for surgical interventions were enrolled and 28 patients were analyzed in the study. Baseline 30-min rs-fMRI scanning, verbal memory and language assessments were collected for each patient before surgery. Personalized verbal memory networks (PVMN) were delineated based on preoperative rs-fMRI data for each patient. The accuracy of PVMN was assessed by comparing post-operative functional impairments and the overlapping extent between PVMN and surgical lesions. A total of 14 out of 28 patients experienced clinically meaningful declines in verbal memory after surgery. The personalized network and the group-level atlas exhibited 100% and 75.0% accuracy in predicting postoperative verbal memory declines, respectively. Moreover, six patients with extra-temporal lesions that overlapped with PVMN showed selective impairments in verbal memory. Furthermore, the lesioned ratio of the personalized network rather than the group-level atlas was significantly correlated with postoperative declines in verbal memory (personalized networks: r = -0.39, p = .038; group-level atlas: r = -0.19, p = .332). In conclusion, our personalized functional mapping technique, using precision rs-fMRI, offers valuable insights into individual variability in the verbal memory network and holds promise in precision verbal memory network mapping in individuals.


Asunto(s)
Mapeo Encefálico , Imagen por Resonancia Magnética , Humanos , Femenino , Masculino , Adulto , Adulto Joven , Mapeo Encefálico/métodos , Trastornos de la Memoria/etiología , Trastornos de la Memoria/diagnóstico por imagen , Trastornos de la Memoria/fisiopatología , Persona de Mediana Edad , Epilepsia Refractaria/cirugía , Epilepsia Refractaria/diagnóstico por imagen , Epilepsia Refractaria/fisiopatología , Adolescente , Red Nerviosa/diagnóstico por imagen , Red Nerviosa/fisiopatología , Red Nerviosa/cirugía , Complicaciones Posoperatorias/diagnóstico por imagen , Procedimientos Neuroquirúrgicos , Aprendizaje Verbal/fisiología , Epilepsia del Lóbulo Temporal/cirugía , Epilepsia del Lóbulo Temporal/diagnóstico por imagen , Epilepsia del Lóbulo Temporal/fisiopatología
3.
J Surg Res ; 294: 26-36, 2024 02.
Artículo en Inglés | MEDLINE | ID: mdl-37857140

RESUMEN

INTRODUCTION: The prognosis and optimal treatment approach for stage I mixed germ cell cancers of the testis are not well-established. This study aimed to assess contemporary treatment rates and their correlation with the cancer-specific mortality (CSM) and other-cause mortality (OCM) in patients with stage I testicular mixed germ cell tumors (TMGCT) who underwent orchiectomy, comparing surveillance with active treatment, including chemotherapy (CHT) and retroperitoneal lymph node dissection (RPLND). METHODS: Retrospective analysis of clinical data from stage I TMGCT patients who underwent orchiectomy was conducted using the Surveillance, Epidemiology, and End Results database from 2004 to 2019. The annual percentage change (APC) in the use of surveillance, postoperative CHT, and RPLND was examined. Propensity score matching (PSM) and cumulative incidence, analyses were employed to compare differences in CSM and OCM between surveillance and active treatment, as well as between CHT and RPLND. Multivariate competing-risks regression models were utilized to investigate independent factors affecting CSM and OCM among stage I TMGCT patients. RESULTS: The study included 5743 individuals with stage I TMGCT that underwent surveillance (61.6%), CHT(27.2%), or RPLND (11.2%). Among them, 82 deaths were attributed to TMGCT, and 82 deaths resulted from other causes. Surveillance rates increased over time (APC: 0.635%, P = 0.008), as did CHT rates (APC: 0.863%, P < 0.001), while RPLND rates declined (APC: -0.96%, P < 0.001). After PSM, multivariate competing-risks regression analysis showed that, active treatment, compared to surveillance, was not an independent factor for CSM and OCM. In contrast, when compared to CHT, RPLND was an independent factor associated with lower CSM (hazard ratio = 0.247, 95% confidence interval: 0.08-0.761; P = 0.015), but not OCM (hazard ratio = 0.946, 95% confidence interval: 0.377-2.37; P = 0.91). CONCLUSIONS: Surveillance and CHT rates have increased over time for patients with stage I TMGCT following initial orchiectomy, while RPLND utilization has decreased. There was no significant difference in CSM between surveillance and active treatment groups, but RPLND demonstrated significantly lower CSM than CHT in active treatment. Our findings suggest that the usage of RPLND in patients with stage I TMGCT should be reconsidered.


Asunto(s)
Neoplasias de Células Germinales y Embrionarias , Neoplasias Testiculares , Masculino , Humanos , Orquiectomía/métodos , Pronóstico , Estudios Retrospectivos , Puntaje de Propensión , Neoplasias de Células Germinales y Embrionarias/cirugía , Neoplasias de Células Germinales y Embrionarias/patología , Neoplasias Testiculares/cirugía , Escisión del Ganglio Linfático/métodos , Espacio Retroperitoneal/cirugía , Estadificación de Neoplasias
4.
Acta Pharmacol Sin ; 2024 May 08.
Artículo en Inglés | MEDLINE | ID: mdl-38719955

RESUMEN

Pulmonary hypertension (PH) is a progressive fatal disease with no cure. Canagliflozin (CANA), a novel medication for diabetes, has been found to have remarkable cardiovascular benefits. However, few studies have addressed the effect and pharmacological mechanism of CANA in the treatment of PH. Therefore, our study aimed to investigate the effect and pharmacological mechanism of CANA in treating PH. First, CANA suppressed increased pulmonary artery pressure, right ventricular hypertrophy, and vascular remodeling in both mouse and rat PH models. Network pharmacology, transcriptomics, and biological results suggested that CANA could ameliorate PH by suppressing excessive oxidative stress and pulmonary artery smooth muscle cell proliferation partially through the activation of PPARγ. Further studies demonstrated that CANA inhibited phosphorylation of PPARγ at Ser225 (a novel serine phosphorylation site in PPARγ), thereby promoting the nuclear translocation of PPARγ and increasing its ability to resist oxidative stress and proliferation. Taken together, our study not only highlighted the potential pharmacological effect of CANA on PH but also revealed that CANA-induced inhibition of PPARγ Ser225 phosphorylation increases its capacity to counteract oxidative stress and inhibits proliferation. These findings may stimulate further research and encourage future clinical trials exploring the therapeutic potential of CANA in PH treatment.

5.
Echocardiography ; 41(3): e15802, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-38527007

RESUMEN

The right sinus of the Valsalva aneurysm (SVA) rupturing into the right atrium (RA) and dissecting into the interventricular septum (IVS) is rare. The disease can be definitively diagnosed using two-dimensional (2D) echocardiography and color Doppler ultrasonography. Real-time biplane imaging and three-dimensional (3D) echocardiography offer new perspectives for viewing and diagnosing this disease.


Asunto(s)
Aneurisma Roto , Aneurisma de la Aorta , Disección Aórtica , Rotura de la Aorta , Seno Aórtico , Tabique Interventricular , Humanos , Aneurisma de la Aorta/complicaciones , Aneurisma de la Aorta/diagnóstico por imagen , Seno Aórtico/diagnóstico por imagen , Atrios Cardíacos/diagnóstico por imagen
6.
J Exerc Sci Fit ; 22(4): 350-358, 2024 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-39027081

RESUMEN

Objective: The aims of this study were to examine the effect of SARS-CoV-2 infection on cardiorespiratory fitness (CRF) and time-trial performance in vaccinated well-trained young kayak athletes. Methods: This is a longitudinal observational study. Sixteen (7 male, 9 female) vaccinated kayakers underwent body composition assessment, maximal graded exercise test, and 1000-m time-trial tests 21.9 ± 1.7 days before and 66.0 ± 2.2 days after the SARS-CoV-2 infection. The perception of training load was quantified with Borg's CR-10 scale before and after the infection return to sport period. Results: There were significant decreases in peak oxygen uptake (-9.7 %; effect size [ES] = 1.38), peak oxygen pulse (-5.7 %; ES = 0.96), and peak heart rate (-1.9 %; ES = 0.61). Peak minute ventilation, and minute ventilation/carbon dioxide production slope were unchanged after infection compared to the pre-infection values. In the entire 1000-m, the impaired tendencies were found in completion time, mean power, and mean speed (-2.4 to 1.2 %; small ESs = -0.40 to 0.47) as well as significant changes in stroke rate and stroke length (-4.5 to 3.7 %; ESs = -0.60 to 0.73). Conclusion: SARS-CoV-2 infection decreased CRF and time-trial performance even two months after return to regular training in vaccinated athletes.

7.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 41(2): 237-245, 2024 Apr 25.
Artículo en Zh | MEDLINE | ID: mdl-38686403

RESUMEN

The PET/CT imaging technology combining positron emission tomography (PET) and computed tomography (CT) is the most advanced imaging examination method currently, and is mainly used for tumor screening, differential diagnosis of benign and malignant tumors, staging and grading. This paper proposes a method for breast cancer lesion segmentation based on PET/CT bimodal images, and designs a dual-path U-Net framework, which mainly includes three modules: encoder module, feature fusion module and decoder module. Among them, the encoder module uses traditional convolution for feature extraction of single mode image; The feature fusion module adopts collaborative learning feature fusion technology and uses Transformer to extract the global features of the fusion image; The decoder module mainly uses multi-layer perceptron to achieve lesion segmentation. This experiment uses actual clinical PET/CT data to evaluate the effectiveness of the algorithm. The experimental results show that the accuracy, recall and accuracy of breast cancer lesion segmentation are 95.67%, 97.58% and 96.16%, respectively, which are better than the baseline algorithm. Therefore, it proves the rationality of the single and bimodal feature extraction method combining convolution and Transformer in the experimental design of this article, and provides reference for feature extraction methods for tasks such as multimodal medical image segmentation or classification.


Asunto(s)
Algoritmos , Neoplasias de la Mama , Tomografía Computarizada por Tomografía de Emisión de Positrones , Humanos , Neoplasias de la Mama/diagnóstico por imagen , Femenino , Tomografía Computarizada por Tomografía de Emisión de Positrones/métodos , Procesamiento de Imagen Asistido por Computador/métodos , Redes Neurales de la Computación , Aprendizaje Automático , Interpretación de Imagen Asistida por Computador/métodos
8.
J Sports Sci Med ; 23(2): 418-424, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38841636

RESUMEN

To determine how lateral shuffling/lateral shuffle (LS) -induced fatigue affects ankle proprioception and countermovement jump (CMJ) performance. Eighteen male college athletes performed 6 modes of a repeated LS protocol with 2 distances (2.5 and 5 m) and 3 speeds (1.6, 1.8, and 2.0 m/s). After LS, ankle inversion proprioception (AIP) was measured using the active movement extent discrimination apparatus (AMEDA). CMJ, blood lactate (BLa), heart rate (HR) and rating of perceived exertion (RPE) were measured before and after LS. The number of changes of direction (CODs) in each protocol was recorded. LS-induced fatigue was evident in BLa, HR and RPE (all p < 0.05), increasing with shorter shuffle distance and faster speed. RM-ANOVA showed a significant distance main effect on both AIP (p < 0.01) and CMJ (p < 0.05), but the speed main effect was only significant for CMJ (p ≤ 0.001), not AIP (p = 0.87). CMJ performance was correlated with BLa, HR and RPE (r values range from -0.62 to -0.32, all p ≤ 0.001). AIP was only correlated with CODs (r = -0.251, p < 0.01). These results suggested that in LS, shorter distance, regardless of speed, was associated with worse AIP, whereas subsequent CMJ performance was affected by both LS distance and speed. Hence, AIP performance was not related to physiological fatigue, but CMJ performance was. Results imply that LS affects processing proprioceptive input and producing muscular output differently, and that these two aspects of neuromuscular control are affected by physiological fatigue to varying degrees. These findings have implications for injury prevention and performance enhancement.


Asunto(s)
Tobillo , Rendimiento Atlético , Frecuencia Cardíaca , Ácido Láctico , Fatiga Muscular , Propiocepción , Humanos , Masculino , Propiocepción/fisiología , Adulto Joven , Frecuencia Cardíaca/fisiología , Fatiga Muscular/fisiología , Tobillo/fisiología , Rendimiento Atlético/fisiología , Ácido Láctico/sangre , Ejercicio Pliométrico , Esfuerzo Físico/fisiología
9.
Int J Sports Med ; 44(14): 1013-1033, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-37364608

RESUMEN

The aim of the present study is to determine the associations between lower body muscle strength qualities and change of direction (CoD) performance. Three databases were used to perform a systematic literature search up to September 30, 2022. Based on the studies that met the inclusion criteria, we calculated Pearson's r correlation coefficient to examine the relationships between muscle strength qualities and CoD performance. The quality of the studies included was evaluated by the modified version of the Downs and Black Quality Index Tool. Heterogeneity was determined via the Q statistic and I 2, and Egger's test was used to assess small study bias. The results revealed that lower body maximal strength (pooled: r=- 0.54, dynamic: r=- 0.60, static: r=- 0.41), joint strength (pooled: r=- 0.59, EXT-ecc: r=- 0.63, FLEX-ecc: r=- 0.59), reactive strength (r=- 0.42) and power (pooled: r=- 0.45, jump height: r=- 0.41, jump distance: r=- 0.60, peak power: r=- 0.41) were negatively and moderately related to CoD performance. To conclude, the results highlight that a number of muscle strength qualities are associated with CoD performance and are pertinent to specific phases of a directional change. It should be noted that the conclusions of this study do not establish causality, and further research is needed to better understand their training effects and underlying mechanisms.


Asunto(s)
Rendimiento Atlético , Humanos , Rendimiento Atlético/fisiología , Fuerza Muscular/fisiología
10.
Sensors (Basel) ; 23(24)2023 Dec 08.
Artículo en Inglés | MEDLINE | ID: mdl-38139545

RESUMEN

Submarine recognition plays a critical role in maritime security and military defense. However, traditional submarine recognition algorithms face limitations in feature representation capability and robustness. Additionally, deploying deep learning methods on embedded and mobile platforms presents a bottleneck. To address these challenges, we propose an innovative and practical approach-an improved YOLOv5-based lightweight submarine automatic recognition detection algorithm. Our method leverages the Feature Pyramid based on MobileNetV3 and the C3_DS module to reduce computation and parameter complexity while ensuring high precision in submarine recognition. The integration of the adaptive neck from the SA-net strategy further mitigates missed detections, significantly enhancing the accuracy of submarine target detection and recognition. We evaluated our improved model on a submarine dataset, and the results demonstrate remarkable advancements in Precision, Recall, and mAP0.5, with respective increases of 8.54%, 6.02%, and 3.36%. Moreover, we achieved a notable reduction of 34.1% in parameter quantity and 67.9% in computational complexity, showcasing its lightweight effects. Overall, our proposed method introduces novel improvements to submarine recognition, addressing existing limitations and offering practical benefits for real-world deployment on embedded and mobile platforms. The enhanced performance in precision and recall metrics, coupled with reduced computational requirements, emphasizes the significance of our approach in enhancing maritime security and military applications.

11.
J Exerc Sci Fit ; 21(4): 354-365, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-37701124

RESUMEN

Objective: to (1) systematically review the chronic effect of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on maximal fat oxidation (MFO) in overweight and obese adults, and (2) explore MFO influencing factors and its dose-response relationships with HIIT and MICT. Methods: Studies using a between-group design involving overweight and obese adults and assessing the effect of HIIT and MICT on MFO were included. A meta-analysis on MFO indices was conducted, and the observed heterogeneities were explored through subgroup, regression, and sensitivity analyses. Results: Thirteen studies of moderate to high quality with a total of 519 overweight and obese subjects were included in this meta-analysis (HIIT, n = 136; MICT, n = 235; Control, n = 148). HIIT displayed a statistically significant favorable effect on MFO compared to no-training (MD = 0.07; 95%CI [0.03 to 0.11]; I2 = 0%). Likewise, MICT displayed a statistically significant favorable effect on MFO compared to no-training (MD = 0.10; 95%CI [0.06 to 0.15]; I2 = 95%). Subgroup and regression analyses revealed that exercise intensity (Fatmax vs. non-Fatmax; %VO2peak), exercise mode, BMI, and VO2peak all significantly moderated MICT on MFO. When analyzing studies that have directly compared HIIT and MCIT in obese people, it seems there is no difference in the MFO change (MD = 0.01; 95%CI [-0.02 to 0.04]; I2 = 64%). No publication bias was found in any of the above meta-analyses (Egger's test p > 0.05 for all). Conclusion: Both HIIT and MICT are effective in improving MFO in overweight and obese adults, and they have similar effects. MCIT with an intensity of 65-70% VO2peak, performed 3 times per week for 60 min per session, will optimize MFO increases in overweight and obese adults. Given the lack of studies examining the effect of HIIT on MFO in overweight and obese adults and the great diversity in the training protocols in the existing studies, we were unable to make sound recommendations for training.

12.
J Exerc Sci Fit ; 21(4): 345-353, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-37701125

RESUMEN

Purpose: This study aimed to examine the short-term effects of SARS-CoV-2 infection and return to sport (RTS) on neuromuscular performance, body composition, and mental health in well-trained young kayakers. Methods: 17 vaccinated kayakers (8 male, 9 female) underwent body composition assessment, peak power output bench press (BP), and 40-s maximum repetition BP tests 23.9 ± 1.6 days before and 22.5 ± 1.6 days after a SARS-CoV-2 infection. A linear transducer was used to examine the BP performance. The perception of training load and mental health were quantified with Borg's CR-10 scale and the Hooper questionnaire before and after infection. The difference and relationship of variables were used Wilcoxon test, Student t-test, Pearson's, and Spearman's r correlation coefficients. Results: There was a significant increase in body mass, fat-free mass, and skeletal muscle mass, but no significant changes in body fat, fat mass, and all BP performance after infection (p < 0.05). There was a significant reduction in training hours per week, session rating of perceived exertion (sRPE), internal training load (sRPE-TL), fatigue, muscle soreness levels, and Hooper index, but no changes in sleep quality and stress levels after infection (p < 0.05). The training and mental health during the RTS period was significantly correlated (r = -0.85 to 0.70) with physical performance after infection. Conclusion: A SARS-CoV-2 infection did not appear to impair the upper-body neuromuscular performance and mental health of vaccinated well-trained young kayakers after a short-term RTS period. These findings can assist coaches, and medical and club staff when guiding RTS strategies after other acute infections or similar restrictions.

13.
Biol Sport ; 40(2): 603-609, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-37077778

RESUMEN

The aim of this study was to determine the optimal velocity loss (VL) threshold that maximises the post activation potentiation (PAP) stimulus for achieving larger and more consistent performance gains in track and field athletes. Twenty-two athletes from athletics participated in four back squat PAP tests with four different VL threshold (5%, 10%, 15% and 20% VL) at an intensity of 85%1RM. Countermovement jump (CMJ) height, power, and momentum were assessed before, and 10 s, 4, 8, 12, 16 minutes after the PAP condition. Repetitions of the squat in all the PAP conditions were also recorded. Only the 5% VL condition produced significant improvements in height (ES = 0.73, P = 0.038), peak power output (ES = 0.73, P = 0.038) and momentum (ES = 0.72, P = 0.041) of CMJ, and these changes appeared 8 minutes after the condition. The total number of repetitions during the 5% VL condition was significantly lower than that observed in the 15% (P = 0.003) and 20% VL (P < 0.001) trials. The results from this study indicate that 5%VL during the 2 sets preconditioning squat at 85%1RM was optimal for eliciting PAP in a CMJ exercise, and resulted in significant increases at the 8-min recovery period. The same squat condition also had the least number of repetitions. However, considering the efficiency in practice, athletes can also choose the rest time of 4-min, which can also achieve similar results.

14.
Circ Res ; 121(4): 451-468, 2017 Aug 04.
Artículo en Inglés | MEDLINE | ID: mdl-28775014

RESUMEN

Neurocardiology is an emerging specialty that addresses the interaction between the brain and the heart, that is, the effects of cardiac injury on the brain and the effects of brain injury on the heart. This review article focuses on cardiac dysfunction in the setting of stroke such as ischemic stroke, brain hemorrhage, and subarachnoid hemorrhage. The majority of post-stroke deaths are attributed to neurological damage, and cardiovascular complications are the second leading cause of post-stroke mortality. Accumulating clinical and experimental evidence suggests a causal relationship between brain damage and heart dysfunction. Thus, it is important to determine whether cardiac dysfunction is triggered by stroke, is an unrelated complication, or is the underlying cause of stroke. Stroke-induced cardiac damage may lead to fatality or potentially lifelong cardiac problems (such as heart failure), or to mild and recoverable damage such as neurogenic stress cardiomyopathy and Takotsubo cardiomyopathy. The role of location and lateralization of brain lesions after stroke in brain-heart interaction; clinical biomarkers and manifestations of cardiac complications; and underlying mechanisms of brain-heart interaction after stroke, such as the hypothalamic-pituitary-adrenal axis; catecholamine surge; sympathetic and parasympathetic regulation; microvesicles; microRNAs; gut microbiome, immunoresponse, and systemic inflammation, are discussed.


Asunto(s)
Encéfalo/metabolismo , Cardiopatías/metabolismo , Corazón/fisiología , Accidente Cerebrovascular/metabolismo , Animales , Encéfalo/patología , Micropartículas Derivadas de Células/fisiología , Microbioma Gastrointestinal/fisiología , Cardiopatías/patología , Humanos , Sistema Hipotálamo-Hipofisario/metabolismo , Sistema Hipófiso-Suprarrenal/metabolismo , Accidente Cerebrovascular/patología
15.
J Org Chem ; 84(12): 8100-8111, 2019 Jun 21.
Artículo en Inglés | MEDLINE | ID: mdl-31117579

RESUMEN

Organocatalytic selenosulfonylation of the C-C double bond of α,ß-unsaturated ketones to construct two contiguous stereogenic centers in an aqueous medium was described. A series of α-selenyl and ß-sulfonyl ketones with various functional groups were synthesized in good yields and enantioselectivities with saturated NaCl solution as the solvent. In addition, this protocol had been successfully scaled up to a decagram scale via a simple workup procedure.

16.
Org Biomol Chem ; 17(5): 1121-1129, 2019 01 31.
Artículo en Inglés | MEDLINE | ID: mdl-30633284

RESUMEN

A metal-free difunctionalization of alkynes to access tetrasubstituted olefins through spontaneous selenosulfonylation of vinylidene ortho-quinone methide (VQM) was described herein. The reaction was conducted under mild conditions without any catalysts or additives. Preliminary mechanism studies revealed that the formation of VQM was the key for this alkyne di-functionalization reaction. The reaction could be applied in the enantioselective asymmetric synthesis of axially chiral styrene. Furthermore, the selenosulfonylation adducts can be transformed into useful naphtho[2,1-b]furan and benzofuran scaffolds.

17.
J Am Chem Soc ; 140(23): 7056-7060, 2018 06 13.
Artículo en Inglés | MEDLINE | ID: mdl-29781611

RESUMEN

We describe herein an organocatalytic enantioselective approach for the construction of axially chiral sulfone-containing styrenes. Various axially chiral sulfone-containing styrene compounds were prepared with excellent enantioselectivities (up to >99% ee) and almost complete E/ Z selectivities (>99% E/ Z). Furthermore, the axially chiral sulfone-containing styrenes could be easily converted into phosphonic acid and S/P ligands, which could be potentially used as organocatalysts or ligands in asymmetric catalysis.

18.
Inorg Chem ; 57(10): 5782-5790, 2018 May 21.
Artículo en Inglés | MEDLINE | ID: mdl-29745656

RESUMEN

The synthesis, Eu3+ complexation, and solvent extraction of Am3+ and Eu3+ from nitric acid solutions by tetradentate phenanthroline-derived bis(pyrazole) (BPPhen) ligands were described. By using meta-nitrobenzotrifluoride as diluent, BPPhen ligands in combination with 2-bromohexanoic acid extracted Am3+ and Eu3+ with remarkably high efficiency, excellent selectivity, and fast extraction kinetics. Stripping posed no issues. The ligands also showed excellent hydrolytic stability and acid tolerance. 2-Bromohexanoic anion neutralized the charge and increased the lipophilicity of the extracted ion pair. The extraction conformed to a cation exchange model. Slope analysis demonstrated the extraction of 1:2 metal/ligand complexes. Analyses by electrospray ionization mass spectrometry, time-resolved laser-induced fluorescence spectroscopy, Raman, and Fourier transform infrared techniques indicated that the composition of the extracted species is [Eu(nOct-BPPhen)2(H2O)]3+. The formation of 1:2 complexes was also confirmed by UV-vis spectroscopic titration and microcalorimetric titration methods. Meanwhile, the stability constants ( K) and the thermodynamic parameters (Δ H, Δ S, Δ G) for the complexation of Eu3+ with nOct-BPPhen were presented too.

19.
Guang Pu Xue Yu Guang Pu Fen Xi ; 36(10): 3297-302, 2016 Oct.
Artículo en Zh | MEDLINE | ID: mdl-30246967

RESUMEN

The inner part of the oil pool flame could be divided into different combustion areas, and there have been a limited number of researches on the heat transfer characteristics within oil pool fire. Due to the lack of adequate researches on the characteristics of heat transfer in oil pool flame, this paper carries out an analytical study to pool flame spectrums of 92# gasoline,95# gasoline and lube by establishing flame infrared testing system. Spectral information about different combustion regions of oil pool fire is collected. The results show that three kinds of oil pool fire have similar spectral characteristics, with several characteristics emission bands of such combustion products as CO2, H2O and carbon black particles and that 3.4 µm C­H stretching vibration peak is obvious; the main spectral characteristics of smoke zone is high temperature CO2 emission peak at the band range of 4~4.5µm, the heat exchange of flame and air is violent; the temperature changes unstably, and flame pulse frequency is high; spectral characteristics in the intermittent area is high temperature CO2 emission peak at 4~4.5 µm; and flame pulse frequency in intermittent zone is relatively lower compared with that in the smoke zone; compared with that in the flue gas zone and intermittent zone, the combustion in continuous zone is more stable, the spectral characteristics of the region is obvious, and carbon black particle emission intensity is high at 2.5~3 µm, and C­H stretching vibration emission peak shows itself at 3.4 µm, which showed that the characteristic peak oil pool flame spectrum at 3.4 µm is caused by high temperature oil vapor steam. Spectral characteristics analysis of the oil pool flame in different combustion areas shows that the heat transfer is absorbed by the fuel rich layer on the surface of the oil pool flame, which leads to the change in the energy level of the oil vapor near 3.4 µm. The calculation of the emission spectrum intensity of oil pool flame in different combustion areas shows that the intensity in flame continuous zone is the largest, followed by the intermittent zone, that the connection between the flame smoke zone and the air is strong, and that the emission spectrum intensity is the lowest. The results in this study provide a reference for the modification of flame oil heat transfer model.

20.
Guang Pu Xue Yu Guang Pu Fen Xi ; 36(10): 3442-8, 2016 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-30247006

RESUMEN

In virtue of the severity and scale of the pollution caused by oil pool flame, space remote sensing can provide us a new way of monitoring in real time the oil pool flame pollution. Space remote sensing monitoring is based on the analysis of target spectrum characteristics. Due to lack of adequate researches on the characteristics of infrared spectrum of oil pool flame, this paper carries out the analytical study on flame spectrums of several types of oil, mixed oil and other combustible objects in outdoor space by establishing all-flame infrared testing system with the spectrum range of 1~14 µm. The results show that the spectrum curves of oil pool flame of 92# gasoline, 95# gasoline, 0# diesel, aviation kerosene and lube have similar features, that there exist characteristics emission peaks at the area of certain wave lengths­H2O characteristics emission peak for 1.1, 2.4, 2.8 and 6.3 µm, CO2 characteristics emission peak for 4.2 and 4.5 µm, C­H stretching vibration emission peak for 3.4 µm, and no obvious characteristics peak for spectrum curves of 6.3 µm and above; that there is no obvious difference in the spectrum of oil pool flame among the mixtures of 92# gasoline and 0# diesel at different proportions, that the comparison of the flame spectrum of 92# gasoline with that of wood and paper shows that there appears a characteristics emission peak at 3.4 µm; that though the flame spectrum of alcohol has similar radiated emission near 3.4 µm, the proportion of its radiation intensity to that of CO2 at 4.5 µm is far less than that for the flame spectrum of 92# gasoline; that the flame spectrum of honeycomb briquette is similar to that of gray body radiation. The differences in flame spectrum among all kinds of combustible materials are closely linked to their chemical compositions and burning reaction mechanisms. Comparative analysis on the spectrum characteristics at continuous area, intermission area and flue gas area shows that C­H stretching vibration peak only exists in continuous area, which proves that the emission peak is caused by the combustible reaction of oil and gas. This result is in line with the mechanism of oil pool combustion reaction. The experimental conclusion is of great significance in the remote-sensing recognition of oil pool flame based on the analysis of spectrum characteristics.

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