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1.
New In Vitro Interaction-Parasite Reduction Ratio Assay for Early Derisk in Clinical Development of Antimalarial Combinations.
Antimicrob Agents Chemother
; 66(11): e0055622, 2022 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36197116
2.
Parasite Viability as a Measure of In Vivo Drug Activity in Preclinical and Early Clinical Antimalarial Drug Assessment.
Antimicrob Agents Chemother
; 66(7): e0011422, 2022 07 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35727057
3.
A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria.
Malar J
; 20(1): 222, 2021 May 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-34011358
4.
A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048.
Clin Infect Dis
; 71(10): e657-e664, 2020 12 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-32239164
5.
A pharmacokinetic-pharmacodynamic model for chemoprotective agents against malaria.
CPT Pharmacometrics Syst Pharmacol
; 12(1): 50-61, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36412499
6.
The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro.
Pharmaceuticals (Basel)
; 16(2)2023 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-37009844
7.
Chemoprotective Antimalarial Activity of P218 against Plasmodium falciparum: A Randomized, Placebo-Controlled Volunteer Infection Study.
Am J Trop Med Hyg
; 104(4): 1348-1358, 2021 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33556040
8.
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
Sci Transl Med
; 13(603)2021 07 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34290058
9.
A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions.
PLoS One
; 12(9): e0183794, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28910306
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