Imaging needle for optical coherence tomography.

We describe a miniature optical coherence tomography (OCT) imaging needle that can be inserted into solid tissues and organs to permit interstitial imaging of their internal microstructures with micrometer scale resolution and minimal trauma. A novel rotational coupler with a glass capillary tube is also presented that couples light from a rotating single-mode fiber to a stationary one. A prototype needle with a 27-gauge (approximately 410-microm) outer diameter has been developed and is demonstrated for in vivo imaging. The OCT needle can be integrated with standard excisional biopsy devices and used for OCT-guided biopsy.

Self-starting mode locking in a Cr:forsterite laser by use of non-epitaxially-grown semiconductor-doped silica films.

We demonstrate RF sputtered, non-epitaxially-grown semiconductor nanocrystallite-doped silica films for mode locking a Cr:forsterite laser. We controlled the size and the optical properties of the nanocrystallites by varying the ratio of InAs to SiO(2) during fabrication. Femtosecond pump-probe measurements were performed to characterize the nonlinear optical properties of these films, revealing their lower saturation fluences. Using the InAs-doped silica films as saturable absorbers permitted self-starting Kerr-lens mode locking (KLM), generating pulses of 25-fs duration with 91-nm spectral bandwidth at 1.3 microm . We also describe saturable-absorber mode-locked operation without KLM and investigate its dependence on intracavity dispersion.

Generation of 20-fs pulses by a prismless Cr(4+):YAG laser.

Ultrafast optical pulses shorter than 20 fs with 400-mW average power at a 110-MHz repetition rate have been generated by a Cr(4+):YAG laser with only double-chirped mirrors for dispersion compensation. The corresponding pulse spectrum has a peak intensity at 1450 nm and extends from 1310 to 1500 nm full width at half-maximum (FWHM). These pulses, which are believed to be the shortest generated to date from a Cr(4+):YAG laser, are only four optical cycles within the FWHM intensity width.

All-solid-state Cr:forsterite laser generating 14-fs pulses at 1.3 mum.

We report the generation of 14-fs pulses at 1.3mum with 80-mW average power at 100-MHz repetition rate by an all-solid-state Kerr-lens mode-locked Cr:forsterite laser. The laser spectrum covers wavelengths of 1230-1580 nm, with a FWHM of 250 nm. Since 1.3-mum wavelengths are close to the zero dispersion wavelength of Cr:forsterite, higher-order dispersion is the main factor limiting pulse durations. We use specially designed and fabricated double-chirped mirrors in combination with high-index PBH71 prisms to compensate for the intracavity dispersion over almost 300 nm.

Ultrahigh-resolution optical coherence tomography using continuum generation in an air-silica microstructure optical fiber.

We demonstrate ultrahigh-resolution optical coherence tomography (OCT) using continuum generation in an air-silica microstructure fiber as a low-coherence light source. A broadband OCT system was developed and imaging was performed with a bandwidth of 370 nm at a 1.3-mu;m center wavelength. Longitudinal resolutions of 2.5 microm in air and ~2 microm in tissue were achieved. Ultrahigh-resolution imaging in biological tissue in vivo was demonstrated.