Detalles de la búsqueda
1.
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
J Med Chem
; 2024 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-38687966
2.
Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography Ligand.
J Med Chem
; 66(3): 1712-1724, 2023 02 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36256881
3.
Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life.
ACS Med Chem Lett
; 14(10): 1427-1433, 2023 Oct 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37849537
4.
Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss.
J Med Chem
; 66(5): 3195-3211, 2023 03 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36802610
5.
Anti-PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC.
JCI Insight
; 7(3)2022 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35132961
6.
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling.
J Clin Invest
; 118(1): 64-78, 2008 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18079969
7.
6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3ß inhibitors.
Bioorg Med Chem Lett
; 21(5): 1429-33, 2011 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21295469
8.
Diamide amino-imidazoles: a novel series of γ-secretase inhibitors for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 21(9): 2631-6, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21269825
9.
Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: discovery of PF-3084014.
Bioorg Med Chem Lett
; 21(9): 2637-40, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21269827
10.
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Science
; 374(6575): 1586-1593, 2021 Dec 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34726479
11.
Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014.
J Pharmacol Exp Ther
; 334(1): 269-77, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20363853
12.
Insertion of scFv into the hinge domain of full-length IgG1 monoclonal antibody results in tetravalent bispecific molecule with robust properties.
MAbs
; 9(2): 240-256, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-27981887
13.
Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.
J Med Chem
; 60(18): 7764-7780, 2017 09 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28817277
14.
Differential EphA2 epitope display on normal versus malignant cells.
Cancer Res
; 63(22): 7907-12, 2003 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-14633720
15.
Effects of the cyclooxygenase inhibitor, piroxicam, in combination with chemotherapy on tumor response, apoptosis, and angiogenesis in a canine model of human invasive urinary bladder cancer.
Mol Cancer Ther
; 2(2): 183-8, 2003 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-12589035
16.
Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.
J Med Chem
; 58(1): 419-32, 2015 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-25353650
17.
Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.
J Med Chem
; 57(3): 861-77, 2014 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24392688
18.
Metabolism of a serotonin-4 receptor partial agonist 4-{4-[4-tetrahydrofuran-3-yloxy)-benzo[d]isoxazol-3-yloxymethyl]-piperidin-1-ylmethyl}-tetrahydropyran-4-ol (TBPT): identification of an unusual pharmacologically active cyclized oxazolidine metabolite in human.
J Pharm Sci
; 102(9): 3277-93, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23589342
19.
MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models.
Int J Oncol
; 40(5): 1321-30, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22327175
20.
Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive disorders.
J Med Chem
; 55(21): 9045-54, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22780914