RESUMEN
Chromosome 6 is a metacentric chromosome that constitutes about 6% of the human genome. The finished sequence comprises 166,880,988 base pairs, representing the largest chromosome sequenced so far. The entire sequence has been subjected to high-quality manual annotation, resulting in the evidence-supported identification of 1,557 genes and 633 pseudogenes. Here we report that at least 96% of the protein-coding genes have been identified, as assessed by multi-species comparative sequence analysis, and provide evidence for the presence of further, otherwise unsupported exons/genes. Among these are genes directly implicated in cancer, schizophrenia, autoimmunity and many other diseases. Chromosome 6 harbours the largest transfer RNA gene cluster in the genome; we show that this cluster co-localizes with a region of high transcriptional activity. Within the essential immune loci of the major histocompatibility complex, we find HLA-B to be the most polymorphic gene on chromosome 6 and in the human genome.
Asunto(s)
Cromosomas Humanos Par 6/genética , Genes/genética , Mapeo Físico de Cromosoma , Animales , Exones/genética , Enfermedades Genéticas Congénitas/genética , Antígenos HLA-B/genética , Humanos , Seudogenes/genética , ARN de Transferencia/genética , Análisis de Secuencia de ADNAsunto(s)
Acidosis/tratamiento farmacológico , Carcinoma de Células Pequeñas/tratamiento farmacológico , Lactatos , Neoplasias Pulmonares/tratamiento farmacológico , Antineoplásicos/uso terapéutico , Bicarbonatos/uso terapéutico , Humanos , Neoplasias Hepáticas/secundario , Masculino , Persona de Mediana Edad , Pronóstico , Bicarbonato de SodioRESUMEN
Fifteen patients with known metastatic or high-risk primary cancer, normal neurologic examinations, and new abnormalities on 99mTc bone scan were evaluated with spinal CT and magnetic resonance (MR) imaging. Four patients underwent CT metrizamide myelography. Spinal CT and MR agreed in 14 of 15 patients demonstrating spinal metastases in 12 patients and benign disease in two. In one patient spinal CT was normal, but MR showed altered marrow signal consistent with metastatic disease. Epidural tumor was demonstrated by CT metrizamide myelography in four cases, all correctly identified by MR. Further evaluation of spinal MR in this setting is warranted.