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Chem Soc Rev ; 51(20): 8652-8675, 2022 Oct 17.
Artículo en Inglés | MEDLINE | ID: mdl-36172989

RESUMEN

Carbocycles are a key and widely present structural motif in organic compounds. The construction of structurally intriguing carbocycles, such as highly-strained fused rings, spirocycles or highly-functionalized carbocycles with congested stereocenters, remains challenging in organic chemistry. Cyclopropanes, cyclobutanes and cyclopentanes within such carbocycles can be synthesized through ring contraction. These ring contractions involve re-arrangement of and/or small molecule extrusion from a parental ring, which is either a carbocycle or a heterocycle of larger size. This review provides an overview of synthetic methods for ring contractions to form cyclopropanes, cyclobutanes and cyclopentanes en route to structurally intriguing carbocycles.


Asunto(s)
Ciclobutanos , Ciclización , Ciclobutanos/química , Ciclopentanos/química , Ciclopropanos/química , Estereoisomerismo
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