RESUMEN
INTRODUCTION: While there is much information about the burden of influenza A(H1N1)pdm09 in North America, little data exist on its burden in South America. METHODS: During April to December 2009, we actively searched for persons with severe acute respiratory infection and influenza-like illness (ILI) in three sentinel cities. A proportion of case-patients provided swabs for influenza testing. We estimated the number of case-patients that would have tested positive for influenza by multiplying the number of untested case-patients by the proportion who tested positive. We estimated rates by dividing the estimated number of case-patients by the census population after adjusting for the proportion of case-patients with missing illness onset information and ILI case-patients who visited physicians multiple times for one illness event. RESULTS: We estimated that the influenza A(H1N1)pdm09 mortality rate per 100,000 person-years (py) ranged from 1.5 among persons aged 5-44 years to 5.6 among persons aged ≥ 65 years. A(H1N1)pdm09 hospitalization rates per 100,000 py ranged between 26.9 among children aged <5 years to 41.8 among persons aged ≥ 65 years. Influenza A(H1N1)pdm09 ILI rates per 100 py ranged between 1.6 among children aged <5 to 17.1 among persons aged 45-64 years. While 9 (53%) of 17 influenza A(H1N1)pdm09 decedents with available data had obesity and 7 (17%) of 40 had diabetes, less than 4% of surviving influenza A(H1N1)pdm09 case-patients had these pre-existing conditions (p ≤ 0.001). CONCLUSION: Influenza A(H1N1)pdm09 caused a similar burden of disease in Argentina as in other countries. Such disease burden suggests the potential value of timely influenza vaccinations.
Asunto(s)
Subtipo H1N1 del Virus de la Influenza A , Gripe Humana , Síndrome Respiratorio Agudo Grave , Adolescente , Adulto , Argentina , Niño , Preescolar , Femenino , Hospitalización , Humanos , Lactante , Subtipo H1N1 del Virus de la Influenza A/genética , Subtipo H1N1 del Virus de la Influenza A/patogenicidad , Gripe Humana/complicaciones , Gripe Humana/mortalidad , Gripe Humana/fisiopatología , Masculino , Persona de Mediana Edad , Pandemias , Síndrome Respiratorio Agudo Grave/complicaciones , Síndrome Respiratorio Agudo Grave/epidemiología , Síndrome Respiratorio Agudo Grave/fisiopatologíaRESUMEN
INTRODUCCION: El brote de dengue de 2009 constituyó el primero con casos autóctonos en Tucumán. Los departamentos de Río Chico y Capital fueron los más afectados. Hubo baja notificación de niños de uno a nueve años (2,6/1.000). Este hallazgo impulsó a conocer el real impacto del brote en la población infantil. OBJETIVO: Estimar la incidencia de dengue en niños de uno a nueve años. METODOS: Se realizó un estudio transversal de sero prevalencia(IgG) en julio de 2009 en Aguilares (Departamento de Río Chico),con una muestra probabilística de niños de uno a nueve años que habían residido allí en los últimos seis meses. Los criterios de exclusión fueron: hogar inhabitado, rechazo a participar o niño con enfermedad aguda. Se utilizó una prueba de neutralización por reducciónde placas. RESULTADOS: Se obtuvieron muestras de 118 niños. Hubo 18 rechazos a participar. El 24...(AU)
INTRODUCTION: The 2009 dengue outbreak became the first with autochthonous cases in Tucumán. The departments of Río Chico and Capital were the most affecte dones. There was low incidence in one- to nine-year-old children(2.6/1000). This finding led to a study to know the real impact of the outbreak on children. OBJECTIVE: To estimate dengue incidence in one- to nine-year-old children. METHODS: Across-sectional seroprevalence (IgG) study was carried out in July 2009 in Aguilares (Department of Río Chico), with aprobability sample composed by one- to nine-year-old children who had lived there in the last six months. Exclusion criteria were: uninhabited home, refusal to participate or seriously illchild. The laboratory study consisted of a plaque reduction neutralization test. RESULTS: A total of 118 samples were obtained. There were 18 refusals to participate. 24...(AU)
Asunto(s)
Humanos , Preescolar , Niño , Dengue/diagnóstico , Virus del Dengue , Estudios Transversales , Anticuerpos/inmunología , Inmunoglobulina G/inmunología , Técnicas de Laboratorio ClínicoRESUMEN
INTRODUCCIÓN: El brote de dengue de 2009 constituyó el primero con casos autóctonos en Tucumán. Los departamentos de Río Chico y Capital fueron los más afectados. Hubo baja notificación de niños de uno a nueve años (2,6/1.000). Este hallazgo impulsó a conocer el real impacto del brote en la población infantil. OBJETIVO: Estimar la incidencia de dengue en niños de uno a nueve años. MÉTODOS: Se realizó un estudio transversal de sero prevalencia(IgG) en julio de 2009 en Aguilares (Departamento de Río Chico),con una muestra probabilística de niños de uno a nueve años que habían residido allí en los últimos seis meses. Los criterios de exclusión fueron: hogar inhabitado, rechazo a participar o niño con enfermedad aguda. Se utilizó una prueba de neutralización por reducciónde placas. RESULTADOS: Se obtuvieron muestras de 118 niños. Hubo 18 rechazos a participar. El 24...
INTRODUCTION: The 2009 dengue outbreak became the first with autochthonous cases in Tucumán. The departments of Río Chico and Capital were the most affecte dones. There was low incidence in one- to nine-year-old children(2.6/1000). This finding led to a study to know the real impact of the outbreak on children. OBJECTIVE: To estimate dengue incidence in one- to nine-year-old children. METHODS: Across-sectional seroprevalence (IgG) study was carried out in July 2009 in Aguilares (Department of Río Chico), with aprobability sample composed by one- to nine-year-old children who had lived there in the last six months. Exclusion criteria were: uninhabited home, refusal to participate or seriously illchild. The laboratory study consisted of a plaque reduction neutralization test. RESULTS: A total of 118 samples were obtained. There were 18 refusals to participate. 24...