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Angew Chem Int Ed Engl
; 62(42): e202304901, 2023 Oct 16.
Artículo
en Inglés
| MEDLINE
| ID: mdl-37403384
RESUMEN
Methanobactin OB3b (Mbn-OB3b) is a unique natural product with stunning affinity for copper ions (Ka ≈Cu(I) 1034 ). Here, we report the first total synthesis of Cu(I)-bound methanobactin OB3b featuring as key transformations a cyclodehydration-thioacylation sequence, to generate the conjugated heterocyclic systems, and a copper-templated cyclization, to complete the caged structure of the very sensitive target compound.