RESUMEN
Although children with Covid-19 generally present with mild symptoms or are often asymptomatic, there is increasing recognition of a delayed multi-organ inflammatory syndrome (MIS-C) following SARS-CoV-2 infection. We report the case of MIS-C associated arrhythmic myocarditis which recovered after anti-inflammatory therapy and immunoglobulin infusion.
Asunto(s)
COVID-19 , Miocarditis , Adolescente , COVID-19/complicaciones , Niño , Humanos , Masculino , Miocarditis/diagnóstico , Miocarditis/etiología , SARS-CoV-2 , Síndrome de Respuesta Inflamatoria Sistémica/diagnóstico , Síndrome de Respuesta Inflamatoria Sistémica/etiologíaRESUMEN
The goal of this paper is to analyze a model of cancer-immune system interactions from [16], and to show how the introduction of control in this model can dramatically improve the hypothetical patient response and in effect prevent the cancer from growing. We examine all the equilibrium points of the model and classify them according to their stability properties. We identify an equilibrium point corresponding to a survivable amount of cancer cells which are exactly balanced by the immune response. This situation corresponds to cancer dormancy. By using Lyapunov stability theory we estimate the region of attraction of this equilibrium and propose two control laws which are able to stabilize the system effectively, improving the results of [16]. Ultimately, the analysis presented in this paper reveals that a slower, continuous introduction of antibodies over a short time scale, as opposed to mere inoculation, may lead to more efficient and safer treatments.
Asunto(s)
Inmunoterapia/métodos , Neoplasias/fisiopatología , Neoplasias/terapia , Algoritmos , Animales , Anticuerpos/química , Vacunas contra el Cáncer/química , Proliferación Celular , Simulación por Computador , Humanos , Sistema Inmunológico , Ratones , Modelos Biológicos , Modelos Estadísticos , Neoplasias/inmunologíaRESUMEN
Recently, a new approach for the controllability of a two-dimensional quantum system S has been proposed, based on its interaction with an initially uncorrelated two-dimensional probe P whose initial state can be arbitrarily modified. Following this scheme and considering a particular model for the environment, we show that, in some specific cases, the environment-induced entanglement is rich enough to completely control the dynamics of S. Under suitable conditions on the interaction of S, P, and the environment, we prove that the state of S can be driven to an arbitrary target state by varying the initial state of P.