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1.
J Intellect Disabil Res ; 66(3): 250-264, 2022 03.
Artículo en Inglés | MEDLINE | ID: mdl-34931390

RESUMEN

BACKGROUND: To describe of the experiences of parents regarding the transition to sexual development of their adolescents with intellectual disabilities who are 15-19 years old. METHODS: This study employs a descriptive interpretative approach and uses Meleis's transitions theory as its theoretical frame of reference. This study uses purposive sampling methods for recruitment. We collected data through individual semi-structured interviews (n = 11) and researcher observations between February 2021 and April 2021 and employed an inductive content analysis approach. RESULTS: Three main themes emerged from the data: parental factors driving the transition process, parents' needs regarding the transition process, and outcomes of the transition process. In addition, most parents struggled to remodel their identities following the transition due to concerns over their adolescent's ability to cope with the challenges of adulthood. CONCLUSION: Considered in the context of middle-range transitions theory, we suggest that parental experiences regarding adolescents' transition to sexual development stem from varying levels of uncertainty and depend on the situation, preferences, and family needs of each individual parent. It is useful to utilise Meleis's transitions theory to understand deeply and explore the impact of the sexual development of adolescents with intellectual disabilities on parents.


Asunto(s)
Discapacidad Intelectual , Adaptación Psicológica , Adolescente , Adulto , Humanos , Padres , Investigación Cualitativa , Conducta Sexual , Adulto Joven
2.
J Laryngol Otol ; 137(3): 259-262, 2023 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-35950484

RESUMEN

OBJECTIVE: To examine the complication rate in adult patients during and after cochlear implantation. METHODS: A retrospective chart review was conducted of patients who had undergone cochlear implantation at a tertiary referral centre between 2009 and 2018. All complications and their treatments were categorised as either minor or major, as well as intra- or post-operative. RESULTS: The records of 392 patients with 395 implants were reviewed. The mean follow-up period was 89 ± 65.5 months (range, 6-408 months). The mean age of patients was 46 ± 15.2 years (range, 19-84 years). Sixty-two patients (16 per cent) had minor complications and 31 (8 per cent) had major complications. CONCLUSION: Although cochlear implantation has the potential for significant intra- and post-operative complications, the actual complication rate is relatively low, and it can therefore be considered a safe procedure.


Asunto(s)
Implantación Coclear , Implantes Cocleares , Humanos , Adulto , Adulto Joven , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Implantación Coclear/efectos adversos , Implantación Coclear/métodos , Estudios Retrospectivos , Implantes Cocleares/efectos adversos , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Centros de Atención Terciaria
3.
J Laryngol Otol ; 135(4): 327-331, 2021 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-33829979

RESUMEN

OBJECTIVE: This study aimed to evaluate and compare cases of simultaneous and consecutive bilateral cochlear implantation from the perspective of the duration of anaesthesia, surgical complications and hospitalisation. METHOD: Fifty patients with simultaneous bilateral cochlear implantation (group 1) and 47 patients with consecutive bilateral cochlear implantation (group 2) were included in this study. The two groups were compared in terms of the duration of anaesthesia, the duration of surgery, radiological findings, the complications and the post-operative hospitalisation time. RESULTS: Group 1 had a significantly shorter operation time than group 2 (p < 0.01). The mean total operation time was 189 minutes in group 1. In group 2, the mean operation times for the first and second surgery were 134 minutes and 136 minutes, respectively, and the total operation time for both surgical procedures in group 2 was 270 minutes. The duration of post-operative hospitalisation of the patients in group 1 was significantly shorter than the total post-operative hospitalisation after both operations for the patients in group 2 (p < 0.01). CONCLUSION: In conclusion, if there is no anatomical problem that may lead to a prolonged operation time or any risk regarding anaesthesia, simultaneous bilateral cochlear implantation can be performed safely.


Asunto(s)
Anestesia/estadística & datos numéricos , Implantación Coclear/métodos , Tiempo de Internación/estadística & datos numéricos , Tempo Operativo , Preescolar , Femenino , Humanos , Lactante , Masculino , Estudios Retrospectivos , Factores de Tiempo , Resultado del Tratamiento
4.
Minim Invasive Neurosurg ; 53(2): 60-4, 2010 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-20549602

RESUMEN

INTRODUCTION: Unilateral hemilaminotomy (ULH) and/or bilateral hemilaminotomy (BLH) with limited facetectomy are defined approaches to decompress the thecal sac and exiting lumbar nerve roots without increasing the risk of subsequent spinal instability. METHODS: We retrospectively analyzed 18 cases with degenerative lumbar spinal stenosis (LSS) with BLH or ULH that was performed in 11 and 7 cases, respectively. Magnetic resonance imaging (MRI) was performed at the follow-up examination and dural sac area (DSA) was calculated on T(2)-weighted MRI images and then compared statistically. In addition, the economic and functional status of the patients were evaluated with the Prolo scale. RESULTS: The mean preoperative values on the visual analogue scale (VAS) were 7.1 for lumbalgia and 7.0 for leg pain, respectively. These values were calculated as 4.8 and 4.4 at the follow-up, respectively. The VAS was significantly improved after operation compared to preoperative values (p=0.001). The mean value of the DSA was 84 (+/-32) mm(2) before the operation and 126 (+/-35) mm(2) at the follow-up and the comparison was statistically significant (p=0.001). No statistical correlation was found between VAS and DSA or between VAS and ULH-BLH groups, however, DSA of the BLH cases was significantly higher than in the ULH group (p=0.035). There was a significant negative correlation between VAS scores (back and leg pain) and Prolo status. However, there was no significant difference between DSA and Prolo scores, and between ULH or BLH groups in terms of Prolo scores. CONCLUSION: A unilateral approach with bilateral decompression and bilateral approach with bilateral hemilaminotomy are both minimal invasive, adequate and safe approaches with excellent prognosis. However, BLH leads to a bigger expansion of DSA.


Asunto(s)
Duramadre/cirugía , Laminectomía/métodos , Vértebras Lumbares/cirugía , Estenosis Espinal/cirugía , Anciano , Descompresión Quirúrgica/métodos , Femenino , Humanos , Dolor de la Región Lumbar/cirugía , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Estudios Retrospectivos , Resultado del Tratamiento
5.
Neurocirugia (Astur) ; 20(2): 159-62, 2009 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-19448960

RESUMEN

Spinal epidural abscess due to Brucella species is usually associated with spondylodiscitis. Urgent surgical decompression should be performed in cases with moderate to severe neurological deficits particularly if progressive. We report clinical features of two cases operated for lumbar epidural abscess caused by Brucella species. Early surgical decompression combined with medical treatment could decrease progression of neurological findings or the severity of complications. Iatrogenic dural tear at the operation should be repaired immediately with fine sutures and fibrin tissue glue to prevent further innoculation into the cerebrospinal axis. These cases should be cautiously followed for any recurrence or neurobrucellosis.


Asunto(s)
Brucella/patogenicidad , Brucelosis/complicaciones , Absceso Epidural , Vértebras Lumbares/patología , Adulto , Brucelosis/patología , Descompresión Quirúrgica , Discitis/etiología , Discitis/microbiología , Absceso Epidural/etiología , Absceso Epidural/microbiología , Femenino , Humanos , Masculino , Persona de Mediana Edad
6.
Neurocirugia (Astur) ; 20(5): 467-9, 2009 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-19830370

RESUMEN

Orbital penetrating injuries may cause significant harm to the optic nerves and eyeball as well as to the brain and cerebral vessels. Management of orbital foreign bodies should include prompt recognition of the extent of the injury, broad-spectrum parenteral antibiotics, tetanus prophylaxis, anticonvulsant medication and early surgical intervention under direct vision to remove the foreign body and to avoid immediate and long-term complications. We report a penetrating orbital injury caused by a bread knife that extended from the orbit to the tegmental dura mater of the temporal bone. The knife's main trajectory coursed through the temporal lobe. Adjacent cerebral structures were explored before removal of the knife.


Asunto(s)
Ceguera/etiología , Lesiones Oculares Penetrantes/cirugía , Traumatismos Penetrantes de la Cabeza/cirugía , Órbita/lesiones , Lóbulo Temporal/lesiones , Adulto , Antibacterianos/uso terapéutico , Anticonvulsivantes/uso terapéutico , Urgencias Médicas , Lesiones Oculares Penetrantes/tratamiento farmacológico , Traumatismos Penetrantes de la Cabeza/tratamiento farmacológico , Traumatismos Penetrantes de la Cabeza/patología , Humanos , Masculino , Órbita/cirugía , Trastornos de la Pupila/etiología , Lóbulo Temporal/cirugía , Toxoide Tetánico
7.
Transplant Proc ; 40(1): 39-41, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18261541

RESUMEN

INTRODUCTION: The gap between cadaver organ donation and waiting list forces us to develop new strategies. Many institutions have turned to emergency departments (ED). METHODS: Patients evaluated as potential organ donors were studied prospectively. RESULTS: Organ Procurement Organizations (OPO) were established in 2006. The Transplantation Department has two coordinators who initiated educational seminars and organized campaigns to improve public awareness about organ donation. A new law that it was mandatory to declare brain death for donors has been accepted. Thereafter, 19 patients were assessed as potential donors, 6 of whom were from the ED. Family consent was obtained for harvest from 9. DISCUSSION: Deaths in the ED are often sudden, unexpected, and traumatic, involving young patients. The emergency physician (EP) has an obligation to care for a dying person to the best of one's abilities. Then, the duty of care is owed to the relatives and friends of the deceased to meet their needs. Finally, the EP should use resources of the health care system in the most efficient manner. Any patient who has been declared brain dead or is scheduled to be taken off life-support measures should be seen as a candidate for transplantation. The coordination between the EP and OPO can change a life lost at the ED into a source of light for others waiting for transplantation. Emergency staff must be alert while evaluating people suffering sudden traumatic and medical death for the possibility that they might be added to the donor pool. CONCLUSION: Educational support and proper management from OPO-like organizations to emergency medical staff will provide better outcomes.


Asunto(s)
Servicio de Urgencia en Hospital , Donantes de Tejidos/estadística & datos numéricos , Adulto , Cadáver , Muerte Súbita , Hospitales Universitarios , Humanos , Unidades de Cuidados Intensivos , Persona de Mediana Edad , Selección de Paciente , Personal de Hospital/educación , Recolección de Tejidos y Órganos/métodos , Obtención de Tejidos y Órganos/métodos , Obtención de Tejidos y Órganos/estadística & datos numéricos , Turquía
8.
Transplant Proc ; 40(1): 310-2, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18261614

RESUMEN

Posttransplant renal dysfunction episodes can result from a variety of causes, including polyomavirus (BK virus)-associated nephropathy (PVAN). It is a well-recognized entity with a high incidence of graft failure. The delicate balance of viral infection and immune regulation in the transplant population would allow development of successful long-term strategies. In this presentation, we have described two PVAN cases of our institution and reviewed the literature.


Asunto(s)
Virus BK , Enfermedades Renales/cirugía , Enfermedades Renales/virología , Trasplante de Riñón/fisiología , Infecciones por Polyomavirus/complicaciones , Adolescente , Niño , Femenino , Humanos , Inmunosupresores/uso terapéutico , Riñón/patología , Riñón/virología , Trasplante de Riñón/inmunología , Resultado del Tratamiento
9.
Transplant Proc ; 40(1): 299-301, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18261610

RESUMEN

Systemic donor infections especially with gram-negative organisms are regarded as an absolute contraindication to cadaveric organ donation for transplantation. This is largely due to fear of transmitting the pathogenic organisms to the immunosuppressed recipient. However, due to the current shortage of organs available for transplantation, clinicians are faced with the option to use organs from infected donors. Between 1996 to January 2006, we collected 44 solid organs. Two out of nine donors had microorganisms from blood cultured. Case 1 was of 23-year old woman whose cause of brain death was intracerebral bleeding due to a traffic accident. The donor had stayed 9 days in the intensive care unit prior to brain death. Two kidneys, two livers (split), and or heart were used. Klebsiella was the organism on blood culture. Case 2 was of 35-year-old man; cause of brain death was cerebral hematoma due to traffic accident. The donor had stayed 6 days prior to brain death onset. The liver and two kidneys were used. Acinetobacter baumannii was yielded upon blood culture. All donors were treated with appropriate antibiotics for at least 48 hours prior to organ procurement with consequent negative blood cultures, while the recipients received the same culture-specific antibiotics for 10 days following transplantation. One donor (case 1) heart and both donor corneas were not used due to infection. All patients are alive with excellent graft function at a median of 90 days following transplantation. In conclusion, our results suggested that bacteremic donors with severe sepsis under proper treatment can be considered for transplantation.


Asunto(s)
Cadáver , Sepsis , Donantes de Tejidos , Recolección de Tejidos y Órganos , Adulto , Antibacterianos/uso terapéutico , Femenino , Humanos , Trasplante de Riñón/fisiología , Trasplante de Hígado/fisiología , Masculino , Selección de Paciente , Sepsis/tratamiento farmacológico
10.
Appl Ergon ; 39(3): 368-78, 2008 May.
Artículo en Inglés | MEDLINE | ID: mdl-17959136

RESUMEN

Ergonomics is a broad science encompassing the wide variety of working conditions that can affect worker comfort and health, including factors such as lighting, noise, temperature, vibration, workstation design, tool design, machine design, etc. This paper describes noise-human response and a fuzzy logic model developed by comprehensive field studies on noise measurements (including atmospheric parameters) and control measures. The model has two subsystems constructed on noise reduction quantity in dB. The first subsystem of the fuzzy model depending on 549 linguistic rules comprises acoustical features of all materials used in any workplace. Totally 984 patterns were used, 503 patterns for model development and the rest 481 patterns for testing the model. The second subsystem deals with atmospheric parameter interactions with noise and has 52 linguistic rules. Similarly, 94 field patterns were obtained; 68 patterns were used for training stage of the model and the rest 26 patterns for testing the model. These rules were determined by taking into consideration formal standards, experiences of specialists and the measurements patterns. The results of the model were compared with various statistics (correlation coefficients, max-min, standard deviation, average and coefficient of skewness) and error modes (root mean square error and relative error). The correlation coefficients were significantly high, error modes were quite low and the other statistics were very close to the data. This statement indicates the validity of the model. Therefore, the model can be used for noise control in any workplace and helpful to the designer in planning stage of a workplace.


Asunto(s)
Lógica Difusa , Industrias , Ruido en el Ambiente de Trabajo/prevención & control , Lugar de Trabajo , Humanos , Modelos Organizacionales , Turquía
11.
Eur Ann Otorhinolaryngol Head Neck Dis ; 134(4): 213-216, 2017 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-28109729

RESUMEN

OBJECTIVE: Olfactory dysfunction is one of the comorbidities associated with allergic rhinitis (AR) and AR is one of the common causes of olfactory problems. We aimed to evaluate by the Sniffin' Sticks test the effects on olfactory functions of nasal steroids and leukotriene antagonists used for allergic rhinitis. METHODS: Thirty patients with seasonal rhinitis were included in this study. Patients were randomly divided into three groups of 10 patients; group 1 received montelukast sodium and mometasone furoate (MF) therapy, group 2 received only montelukast, and group 3 only MF. Patients' olfactory functions were determined using the Sniffin' Sticks olfactory test before and after a month treatment. RESULTS: Threshold, discrimination, identification, and the sum of threshold, discrimination, and identification (TDI) values were not significantly different among the groups before treatment. For Group 1 and Group 3 patients, there were statistically significant differences in threshold, discrimination, identification, and TDI values before and after treatment (P<0.05) (Wilcoxon signed ranks analysis). For Group 2 patients, the before and after treatment values of threshold, discrimination, identification, and TDI showed no significant difference (P>0.05). CONCLUSION: According to the findings of our study, MF is superior to montelukast in improving olfactory function. Although montelukast has been shown to be effective against AR symptoms, its effect on olfactory function was not demonstrated in this study.


Asunto(s)
Acetatos/administración & dosificación , Antialérgicos/administración & dosificación , Glucocorticoides/administración & dosificación , Trastornos del Olfato/tratamiento farmacológico , Quinolinas/administración & dosificación , Rinitis Alérgica/tratamiento farmacológico , Olfato/efectos de los fármacos , Administración Intranasal/métodos , Adolescente , Adulto , Anciano , Ciclopropanos , Humanos , Trastornos del Olfato/etiología , Estudios Prospectivos , Rinitis Alérgica Estacional/tratamiento farmacológico , Umbral Sensorial , Sulfuros , Resultado del Tratamiento
12.
Transplant Proc ; 38(2): 543-7, 2006 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-16549170

RESUMEN

Urologic complications, observed since the beginning of renal transplantation, cause significant morbidity and mortality. In the first few years the procedure was performed, incidence of urologic complications was reported to be 10% to 25%. Recently, the incidence of urologic complications after renal transplantation has decreased to 2.5% to 12.5%; unfortunately, a higher incidence exists in pediatric recipients, reaching approximately 20% with an associated 58% and 74% graft survival rates for cadaveric and living-related transplantation, respectively. We retrospectively analyzed the postoperative urologic complications reported in the medical charts of 1523 consecutive kidney transplantations (1130 men, 74.2%; 393 women, 25.8%; mean age, 31.9 +/- 10.9 years; range, 7 to 64 years; 354 cadaveric, 23.2%; 1169 living, 76.8%) performed by our team since 1975. The first 321 procedures took place at Hacettepe University Hospital in Ankara, Turkey, and the remaining 1202 were performed at Baskent University Hospital in Ankara. Urologic complications occurred in 46 (3%) recipients. Twenty-three (1.5%) of these patients had urine leakage, 15 (1%) had urinary obstruction due to ureteral stricture, 6 (0.4%) had distal ureter necrosis, and 2 (0.1%) developed renal calculi in the late postoperative period. Twenty-four out of 46 required reoperation for urologic complications. The remaining 22 patients were treated conservatively in our interventional radiology department with excellent results. In conclusion, urologic complications will always occur in the posttransplant period. Early diagnosis by experienced personnel and use of interventional radiology can greatly reduce the need for surgical treatment.


Asunto(s)
Trasplante de Riñón/efectos adversos , Enfermedades Urológicas/epidemiología , Adolescente , Adulto , Niño , Femenino , Supervivencia de Injerto , Humanos , Terapia de Inmunosupresión/métodos , Incidencia , Trasplante de Riñón/inmunología , Trasplante de Riñón/métodos , Donadores Vivos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Enfermedades Ureterales/epidemiología , Enfermedades Urológicas/clasificación , Enfermedades Urológicas/etiología
13.
Transplant Proc ; 38(2): 559-61, 2006 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-16549174

RESUMEN

BACKGROUND AND AIM: Some patients who undergo donor hepatectomy for adult living donor liver transplantation develop hypophosphatemia postoperatively. Since this imbalance appears to be a factor in postoperative complications, some authors advocate routine supratherapeutic phosphorus repletion. The purpose of this study was to determine the frequency of hypophosphatemia after elective donor lobectomy for liver transplantation and to assess whether phosphorus repletion is necessary in this patient group. METHODS: The cases of 26 patients who donated 19 right lobe and seven left lateral lobe grafts between August 2004 and March 2005 were evaluated. Postoperative phosphorus levels and other relevant data were obtained from our institution's transplant database. Presence/severity of hypophosphatemia was categorized as follows: normal (>2.5 mg/dL), mild (1.5 to 2.5 mg/dL), moderate (1.1 to 1.5 mg/dL), and profound (<1.0 mg/dL). RESULTS: No patients undergoing donor hepatectomy suffered profound or life-threatening hypophosphatemia and no donor required hyperalimentation for phosphate repletion. Twenty one donors (80.7%) did not have postoperative hypophosphatemia. In addition there appears to be no increased morbidity related to hypophosphatemia. A left lateral segment donor (3.8%) had moderate hypophosphatemia that alleviated with oral intake gradually. Four patients (15.5%; three of right lobe donor, one of left lateral segment donor) had mild hypophosphatemia. We also appropriately corrected the hypophosphatemia with encouragement of normal oral intake. By postoperative day 5, essentially all donor phosphorus levels were corrected to normal range. CONCLUSIONS: The results suggest that hypophosphatemia after donor hepatectomy is not as common as previously reported. We find that appropriate early oral intake postoperatively effectively prevents/minimizes hypophosphatemia in patients who undergo donor hepatectomy.


Asunto(s)
Hepatectomía/efectos adversos , Hipofosfatemia/epidemiología , Trasplante de Hígado , Donadores Vivos , Adulto , Bases de Datos Factuales , Humanos , Persona de Mediana Edad , Fósforo/sangre , Complicaciones Posoperatorias/epidemiología , Cuidados Preoperatorios , Estudios Retrospectivos , Recolección de Tejidos y Órganos/efectos adversos
14.
Transplant Proc ; 38(2): 575-8, 2006 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-16549179

RESUMEN

INTRODUCTION: Liver transplantation is the only curative treatment for patients with cirrhosis and unresectable hepatocellular carcinoma (HCC) without extrahepatic dissemination. Since criteria for transplantation in HCC are controversial, we evaluated our early results of liver transplantation for unresectable HCC. MATERIALS AND METHODS: Three women and 14 men (age range, 1.1 to 64 years) with preoperatively diagnosed or incidentally discovered HCC underwent liver transplantation. Six grafts were obtained from cadaveric donors, and each of the remaining 11 grafts from a living related donor. Criteria for participation, independent of tumor size and number of tumor nodules, were no invasion of major vascular structure and no evidence of extrahepatic disease. In nine patients, tumors were beyond the Milan criteria. Twelve patients (86.7%) received tacrolimus and 2 (13.30%), rapamycin monotherapy with early withdrawal of corticosteroid therapy. Two patients underwent neoadjuvant chemoembolization before transplantation; none received adjuvant chemotherapy. Seven patients with hepatitis B virus infection underwent antiviral prophylaxis with antibody to hepatitis B surface antigens and lamivudine. RESULTS: During follow-up (range, 1 to 17 months), all patients exhibited excellent graft function. Imaging studies revealed no evidence of tumor recurrence and no elevation of alpha fetoprotein or carcinoembryonic antigen levels. DISCUSSION: Low-dose immunosuppressive therapy and expanded criteria for liver transplantation in patients with HCC, especially when donation from a living related donor is possible, appear to inhibit disease recurrence and improve outcomes.


Asunto(s)
Carcinoma Hepatocelular/cirugía , Neoplasias Hepáticas/cirugía , Trasplante de Hígado/métodos , Adolescente , Adulto , Anciano , Cadáver , Preescolar , Femenino , Estudios de Seguimiento , Humanos , Lactante , Donadores Vivos , Masculino , Persona de Mediana Edad , Selección de Paciente , Donantes de Tejidos , Resultado del Tratamiento
15.
Transplant Proc ; 38(2): 584-8, 2006 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-16549181

RESUMEN

Biliary complications are one of the most important problems in liver transplantation. Despite various refinements of surgical technique, liver transplantation is associated with significant numbers of biliary problems. In this article, we describe our novel "intraoperative transhepatic biliary catheter insertion" technique for biliary reconstruction in 29 patients, since November 2004 comparing results before and after its implementation. 5-F Kumpe catheter is inserted into the biliary system in two steps. The first is completed at the back table, and the second during the recipient operation. The grafts were from cadavers in 10 cases, with the remaining ones from living donors. Ten patients received whole-liver grafts, 11 received a right lobe, and eight received a left-lateral lobe or left lobe. The mean weight of the living donor grafts was 598 g (range = 270 to 975 g). The mean graft weight-to-body weight ratio in the living donor liver transplantations was 1.6% +/- 1.0% (range, 0.8% to 4.1%). Intraoperative transhepatic biliary catheter insertion was performed with a duct-to-duct anastomosis in 27 cases and with a Roux-en-Y hepaticojejunostomy in two cases. The only biliary complication was one case (3.4%) of bile leakage from the anastomotic site. This rate is significantly lower than that for duct-to-duct biliary reconstructions prior to the new catheter technique (13.0%; P < .05). This new technique of biliary reconstruction with intraoperative biliary catheter insertion has significantly reduced our biliary complication rate. Transhepatic biliary stenting prevents biliary complications and makes it simple to maintain percutaneous access in case such problems arise. However, further studies are needed to compare incidence rates of biliary complications when our novel technique is used versus other surgical techniques.


Asunto(s)
Conductos Biliares/cirugía , Trasplante de Hígado/métodos , Cadáver , Hepatectomía/métodos , Humanos , Donadores Vivos , Procedimientos de Cirugía Plástica , Estudios Retrospectivos , Donantes de Tejidos , Recolección de Tejidos y Órganos/métodos
16.
Transplant Proc ; 38(2): 426-9, 2006 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-16549138

RESUMEN

INTRODUCTION: Various immunological, metabolic, and technical factors render pediatric recipients with end-stage renal disease unique from their adult counterparts. In addition, the potential for complications after renal transplantation is far greater in children than in adults. In this study, we retrospectively analyzed 83 pediatric recipients who underwent kidney transplantation at our institution from 1975 to 2004. MATERIALS AND METHODS: From November 1975 to December 2004, 1523 renal transplantations were performed at our institution with 56 procedures in 83 pediatric patients (44 boys and 39 girls; age range, 7 to 17 years; mean age, 14.9 +/- 2.2 years). RESULTS: Long-term follow-up revealed the following morbidities in 14 (16.3%) recipients: lymphocele in 7 (8.1%) patients, perirenal hematoma in 2 (2.3%), graft renal artery stenosis in 2 (2.3%), ureteral stenosis in 2 (2.3%), and ureteral anastomotic leak in 1 (1.2%). Six (7.2%) recipients with a functioning graft died during follow-up (five deaths were infection related, and the cause of one death was unknown). Five grafts failed (four for immunological reasons and one as a result of recurrent disease). The 1-, 3-, 5-year patient and graft survival rates were 98%, 93%, 92% and 91%, 78%, 67% for living related transplantations versus 98%, 91%, 90% and 92%, 76%, 65% for cadaveric transplantations, respectively. DISCUSSION: Better outcomes for renal transplantation in children may be obtained by strict adherence to precise surgical techniques, better immunosuppressive management, and early diagnosis/effective treatment of complications.


Asunto(s)
Enfermedades Renales/cirugía , Trasplante de Riñón/estadística & datos numéricos , Adolescente , Cadáver , Niño , Femenino , Humanos , Enfermedades Renales/clasificación , Trasplante de Riñón/efectos adversos , Donadores Vivos , Masculino , Complicaciones Posoperatorias/clasificación , Estudios Retrospectivos , Donantes de Tejidos , Insuficiencia del Tratamiento , Resultado del Tratamiento , Turquía
17.
Transplant Proc ; 38(2): 548-51, 2006 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-16549171

RESUMEN

In this study we present our new technique, which will simplify reconstruction of even a small-caliber ureter. Our transplantation team has performed 1523 renal transplantation since 1975. From 1975 to 1983, we performed 300 ureteroneocystostomies using the modified Politano-Leadbetter technique. Since 1983, the extravesical Lich-Gregoir technique was used in combination with temporary ureteral stenting in 1141 patients. After September 2003, we began a corner-saving technique. Eighty-two (62 living related, 20 cadaver) renal transplantations have been performed since September 2003. The mean recipient age was 32.2 +/- 10.9 years (range, 7 to 63). Mean donor age was 38.9 +/- 13.1 years. For ureteral reimplantation, a running suture is started from 3 mm ahead from the middle of the posterior wall and finished 3 mm afterward. After the last stitch, both ends of the suture material are pulled and the posterior wall of the ureter and bladder are approximated tightly. The anterior wall is sewn either with the same suture or another running suture. Since using this technique, we have not employed a double J or any other stent to prevent ureteral complications at the anastomosis side. We have seen only two (2.4%) ureteral complications. In conclusion, due to the low complication rate, we believe that our new technique is the safest way to perform a ureteroneocyctostomy.


Asunto(s)
Trasplante de Riñón/métodos , Uréter/cirugía , Adolescente , Adulto , Cadáver , Niño , Femenino , Humanos , Donadores Vivos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Stents , Donantes de Tejidos , Vejiga Urinaria/cirugía , Urotelio/cirugía
18.
Transplant Proc ; 38(2): 496-8, 2006 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-16549158

RESUMEN

BACKGROUND: There are numerous recent reports on the use of lamivudine for hepatitis B virus (HBV) infection after renal transplantation. However, the optimal strategy (prophylactic, preemptive, or salvage approach) for starting lamivudine treatment in this patient group has not been determined. The aim of this study was to assess how the timing of lamivudine therapy affected the HBV serological status and the transaminase levels in renal allograft recipients with chronic HBV infection. METHODS: We investigated outcomes for patients who were seropositive for hepatitis B surface antigen (HBsAg) and underwent transplantation before or after October 2004 (the date our institution implemented a prophylactic lamivudine treatment strategy against HBV). The data included serum liver enzyme levels and polymerase chain reaction (PCR) screening results for HBV-DNA in serum. RESULTS: Fifteen patients (11 before October 2004, four after October 2004) were included in the study. Preoperatively all patients had normal transaminases levels and 2 of 15 patients had detectable HBV-DNA on PCR. Eight of the 15 total HBsAg-positive patients in our series were not placed on lamivudine at the time of renal transplantation. Half of those who were not treated initially showed transaminase elevations in the first year of follow-up requiring lamivudine therapy at that time. In contrast, all seven individuals who received lamivudine at the time of transplantation were negative for HBV-DNA throughout the follow-up. CONCLUSION: To prevent viral replication in HBsAg-positive patients who are scheduled for renal transplantation, it is best to initiate lamivudine therapy before or immediately after transplantation.


Asunto(s)
Antígenos de Superficie de la Hepatitis B/sangre , Hepatitis B/tratamiento farmacológico , Trasplante de Riñón/fisiología , Lamivudine/uso terapéutico , Antivirales , ADN Viral/genética , ADN Viral/aislamiento & purificación , Hepatitis B/prevención & control , Humanos , Reacción en Cadena de la Polimerasa , Recurrencia , Estudios Retrospectivos
19.
Transplant Proc ; 37(1): 355-8, 2005.
Artículo en Inglés | MEDLINE | ID: mdl-15808642

RESUMEN

OBJECTIVES: Radionuclide imaging is a valuable tool during the early posttransplantation period for evaluating the functional status of renal and liver allografts. The aim of this study was to compare the early postoperative function of renal and liver allografts with serial radionuclide imaging. METHODS: Twenty-two renal and 22 liver allograft recipients were evaluated with serial radionuclide imaging. All grafts were from living related donors. For renal scintigraphy, recipients were injected with Tc-99m DTPA, and imaging was performed on postoperative days 3 and 7. Liver allograft recipients were evaluated with Tc-99m mebrofenin hepatobiliary scintigraphy within the first postoperative week and as required thereafter. The following parameters were computed for each scintigraphy: uptake, time to excretion of the radiopharmaceutical (T(ex)), and retention of radioactivity at the end of the study. RESULTS: Among 22 renal transplant recipients, 19 (86%) had normal uptake and T(ex) values on day 7 posttransplantation. Nine (41%) renal grafts exhibited retention. Among 22 liver transplant recipients, 7 (32%) had normal findings on the first hepatobiliary scan. All except eight liver grafts (64%) had a delay in T(ex), and 15 (68%) had parenchymal retention on the first scan, with improvement of function observed on serial scintigraphies obtained during follow-up. Decreases in uptake were seen less frequently and correlated with a prolonged postoperative hospital stay. CONCLUSION: Renal transplant recipients are more likely than liver allograft recipients to have a normal scintigraphy in the early posttransplantation period. Retention of radioactivity at the end of the study was the most frequently observed abnormality for both renal and liver allografts. Most liver transplant recipients exhibited a delay in excretion, and parenchymal retention, of radioactivity on the first evaluation, with subsequent improvement on follow-up serial scintigraphy studies.


Asunto(s)
Trasplante de Riñón/fisiología , Riñón/diagnóstico por imagen , Trasplante de Hígado/fisiología , Hígado/diagnóstico por imagen , Humanos , Donadores Vivos , Periodo Posoperatorio , Cintigrafía , Radiofármacos/farmacocinética , Pentetato de Tecnecio Tc 99m/farmacocinética , Distribución Tisular , Trasplante Homólogo , Resultado del Tratamiento
20.
Transplant Proc ; 37(2): 1070-3, 2005 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-15848625

RESUMEN

AIMS: The aim of this study was to evaluate liver arteries to depict variations by using multidetector computed tomography (CT) in donor candidates for living related liver transplantation. METHODS: Computed tomographic hepatic angiography was carried out using a multidetector 16-row CT scanner (Sensation 16; Siemens) in 48 candidates between April 2003 and August 2004. Multidetector CT was performed after intravenous injection of 150 mL of contrast material at a rate of 4 mL/s. Arterial phase images were acquired after contrast injection. Afterward, maximum intensity projections and volume-rendered images were produced from the axial image data. Twenty-eight of these patients underwent conventional catheter angiography. RESULTS: Excellent arterial opacification was shown on multidetector CT scans in all patients; arteries up to tertiary branches were identified with CT. Of 28 patients who had both multidetector CT angiography and conventional angiography, only a branch of hepatic artery originating from superior mesenteric artery that supplied the posterior segment of the right lobe was not identified on multidetector CT angiography. In 27 donors, hepatic arterial anatomy depicted at multidetector CT angiography was identical to that at conventional angiography. We identified hepatic vascular variants in 22 of 48 patients with multidetector CT. The most common arterial variant was an accessory hepatic artery arising from the left gastric artery. CONCLUSIONS: Preoperative imaging evaluation of hepatic vascular anatomy is crucial for surgical planning in living related transplant donors. Multidetector CT is useful to depict hepatic arterial anatomy with high accuracy.


Asunto(s)
Hepatectomía/métodos , Arteria Hepática/anatomía & histología , Arteria Hepática/diagnóstico por imagen , Procesamiento de Imagen Asistido por Computador/métodos , Trasplante de Hígado/métodos , Donadores Vivos , Recolección de Tejidos y Órganos/métodos , Adolescente , Adulto , Angiografía , Niño , Preescolar , Femenino , Arteria Hepática/anomalías , Humanos , Lactante , Masculino , Persona de Mediana Edad , Sensibilidad y Especificidad , Tomografía Computarizada por Rayos X
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