Translation of the National Institutes of Health Diabetes Prevention Program in African American churches.

OBJECTIVE: To translate the Diabetes Prevention Program (DPP) for delivery in African American churches. METHODS: Two churches participated in a 6-week church-based DPP and 3 churches participated in a 16-week church-based DPP, with follow-up at 6 and 12 months. The primary outcomes were changes in fasting glucose and weight. RESULTS: There were a total of 37 participants; 17 participated in the 6-session program and 20 participated in the 16-session program. Overall, the fasting glucose decreased from 108.1 to 101.7 mg/dL post intervention (p=.037), and this reduction persisted at the 12-month follow-up without any planned maintenance following the intervention. Weight decreased 1.7 kg post intervention with 0.9 kg regained at 12 months. Body mass index (BMI) decreased from 33.2 to 32.6 kg/m2 post intervention with a final mean BMI of 32.9 kg/m2 at the 12-month check (P<.05). Both the 6- and 16-session programs demonstrated similar reductions in glucose and weight; however, the material costs of implementing the modified 6-session DPP were $934.27 compared to $1075.09 for the modified 16-session DPP. CONCLUSION: Translation of DPP can be achieved in at-risk African Americans if research teams build successful community-based relationships with members of African American churches. The 6-session modified DPP was associated with decreased fasting glucose and weight similar to the 16-session program, with lowered material costs for implementation. Further trials are needed to test the costs and effectiveness of church-based DPPs across different at-risk populations.

A qualitative inquiry into the community and programmatic dimensions associated with successful implementation of church-based diabetes prevention programs.

PURPOSE: This study explored church members' perspectives regarding implementation of a church-based diabetes prevention program (CBDPP) within African American churches. METHODS: Qualitative exploration of themes associated with planning for program implementation and good program outcomes was conducted using a series of four focus groups in churches located in the southeastern United States. Three of these focus groups were conducted with church leaders during the planning phases of program initiation and one focus group involved program participants who had realized the most weight loss and decrease in fasting glucose. Focus group transcripts were subject to content analysis. Participants discussed their views about how to implement a CBDPP within their church and how both the program and broader church community had helped them succeed. RESULTS: Two broad thematic domains emerged with respect to successful CBDPP implementation. The first domain covered church functions and program integration within the church. This was further divided into three thematic clusters relating to church organization, promotion from the pulpit and program visibility, and church service. The second domain addressed the motivational and relationship factors associated with successful program involvement. This was divided into three clusters relating to individuals' motives and beliefs, learning from others, and the support of others. CONCLUSIONS: Implementation of a CBDPP depends on the endorsement by the church leadership, congregational awareness of the program objectives, and active community and program support of CBDPP participants. These occur through a variety of formal and informal channels within the church community.

The effects of a patient-based risk assessment prompt on diabetes screening.

OBJECTIVE: Previous research has determined that nurse-based diabetes risk assessment increases screening and preventive services for patients at risk for type 2 diabetes. This pilot study tested the impact of a diabetes risk assessment completed by patients without nursing assistance. RESEARCH DESIGN AND METHODS: Patients from a family medicine residency clinic completed an American Diabetes Association Risk Assessment questionnaire. Intervention subjects presented completed questionnaires to their physicians. Control subjects returned the questionnaire to the research assistant. Primary endpoints were the number of persons receiving diabetes screening and the number of persons with newly diagnosed diabetes. The associations between the intervention and diabetes screening and diagnosis were assessed using univariate and multivariate logistic regression models. RESULTS: This study included 511 subjects (256 in the intervention group and 255 in the control group). Comparing intervention to control subjects, there was no difference in fasting glucose screening rates. However, odds of diabetes diagnoses were significantly higher using univariate analysis (OR 5.2; 95% CI 1.1-24.3, p=.036) and approached statistical significance after adjusting for other risk factors (OR 4.6; 95% CI 0.92-23.2, p=.063). CONCLUSIONS: A simple patient-based risk assessment used in the outpatient setting may represent a simple, economical method for discovering previously-undiagnosed type 2 diabetes.

Implementing a diabetes prevention program in a rural African-American church.

OBJECTIVES: The purpose of this study was to determine the feasibility of implementing a diabetes prevention program (DPP) in a rural African-American church. METHODS: A six-session DPP, modeled after the successful National Institutes of Health (NIH) DPP, was implemented in a rural African-American church. Adult members of the church identified as high risk for diabetes, based on results of a risk questionnaire, were screened with a fasting glucose. Persons with prediabetes, a fasting glucose of 100-125 mg/dL, participated in the six-session, Lifestyle Balance Church DPP. The primary outcomes were attendance rates and changes in fasting glucose, weight and body mass index measured at baseline, six- and 12-month follow-up. RESULTS: Ninety-nine adult church members were screened for diabetes risk. Eleven had impaired fasting glucose. Ten of 11 participated in the six-session intervention, for an attendance rate of 78%. After the intervention and 12-month follow-up, there was a mean weight loss of 7.9 lbs and 10.6 lbs, respectively. CONCLUSIONS: This pilot project suggests that a modified six-session DPP can be translated to a group format and successfully implemented in a church setting. Further randomized studies are needed to determine the effectiveness of such an intervention.

Ethnic and gender differences in lifestyle risk factors in a bi-ethnic primary care sample: prevalence and clinical implications.

OBJECTIVE: To demonstrate how simple screening methods can be used to define modifiable lifestyle risk factors in primary care settings and educate clinicians regarding ethnic and gender differences in risk factor profiles. DESIGN: Observational study PARTICIPANTS: 3286 patients (1613 African Americans, 1673 non-Hispanic Whites) INTERVENTION: Lifestyle risk factor assessment using nine-question health habits questionnaire and vital signs measurement. MAIN OUTCOME MEASURES: Rates of tobacco use, risky drinking, obesity, and inactivity RESULTS: 29.8% of patients reported tobacco use, 68.9% exercised less than three times per week, 41.1% were obese, and 9.5% screened positive for risky drinking. Whites reported more tobacco use (34.5% vs 24.9%) and risky drinking (10.3% vs 8.8%), while African Americans were more likely to be obese (46.1% vs 36.3%) and inactive (73.2% vs 64.7%). Risky drinking declined in all groups except African American males after age 65. CONCLUSIONS: Simple questionnaires and vital signs measurements are useful in screening for modifiable lifestyle risk factors in primary care clinics. Results can be used to identify risk factor patterns in different ethnic, age, and gender groups and to prioritize prevention interventions for individual patients. Simplified methods of assessing overweight and obesity are needed.

Hemoglobin A1c levels in diagnosed and undiagnosed black, Hispanic, and white persons with diabetes: results from NHANES 1999-2000.

PURPOSE: Although the prevalence of diabetes among various racial/ethnic groups has been well studied, little is known about the racial/ ethnic differences in Hemoglobin A1c (HbA1c) in diagnosed and undiagnosed diabetes. HbA1c correlates with morbidity and mortality in diabetes. Knowledge of the racial/ethnic differences in HbA1c would impact screening and intervention in primary care settings. This study describes racial/ethnic differences in HbA1c among US Black, Hispanic, and White diagnosed and undiagnosed persons with diabetes. METHODS: This study included participants in the 1999-2000 National Health and Nutrition Examination Survey who were > or =20 years old with a HbA1c measurement. The association between HbA1c and race in diagnosed and undiagnosed persons with diabetes (with body mass index [BMI] and age as covariates) was determined. The distribution of HbA1c and mean HbA1c in diagnosed and undiagnosed diabetes and the rates of diagnosed and undiagnosed diabetes with their corresponding HbA1c levels are described by race/ethnicity. RESULTS: Estimated diabetes prevalence in US persons > or =20 years is 8.2%, with 2.3% having undiagnosed diabetes. Whites with diabetes had lower mean HbA1c levels (7.6%, standard error [SEI 0.2) than Blacks (8.1%, SE 0.3) or Hispanics (8.2%, SE .3). Whites with diagnosed diabetes were less likely to have HbA1c> or =11% (1.7%) than Blacks (11.1%) or Hispanics (10.4%). Hispanics with undiagnosed diabetes were more likely to have HbA1c-7% (60.5%) than Blacks (39.3%) or Whites (37.8%). CONCLUSIONS: Significant numbers of persons with diabetes are undiagnosed. There are significant racial/ethnic differences in HbA1c levels, which are significantly higher in Blacks and Hispanics. Comprehensive risk-based screening and intervention for diabetes is needed in order to address racial and ethnic disparities, especially in minorities.

Awareness of diabetes risks is associated with healthy lifestyle behavior in diabetes free American adults: evidence from a nationally representative sample.

PURPOSE: The purpose of this study was to examine whether diabetes free healthy non-Hispanic Whites (NHW), non-Hispanic Blacks (NHB), and Mexican-Americans (MA) who are told of their diabetes risk were more likely to adopt healthy lifestyle behavior defined as current weight control, physical activity and reduced fat/calories intake than those who were not told that they were at increased risk. METHODS: A nationally representative data (n=5073) from the 2007-2008 U.S. National Health and Nutrition Examination Surveys were used for this investigation. Odds ratio from multiple logistic regression analysis was used to determine whether diabetes free NHW, NHB, and MA who are told of their increased diabetes risk were more likely than those who are not told of their diabetes risk to adopt healthy lifestyle behavior. RESULTS: Being told of increased diabetes risk was associated with increased adoption of healthy lifestyle behaviors as indicated by odds ratio of 2.38 (95% CI=1.34-4.05) in NHW, 2.46 (95% CI=1.20-5.05) in NHB and 2.27 (95% CI=1.32-3.89) in MA who have no diabetes, after adjusting for age, sex, race/ethnicity, hypertension, education, household income and total cholesterol. CONCLUSIONS: Awareness of increased risk for diabetes is associated with implementing healthy lifestyle behaviors in diabetes free healthy American adults. Population-based programs designed to assess and communicate diabetes risk may be helpful in preventing or delaying the onset of type 2 diabetes. Programs designed along racial/ethnic line may be needed to reduce racial/ethnic differences in rates of type 2 diabetes.

Applicability of a combination of hemoglobin A(1c) and fasting plasma glucose in population-based prediabetes screening.

BACKGROUND: The purpose of this study is to determine: (i) the concordance between a combination of hemoglobin A(1c) (Hb(A1c)) and fasting plasma glucose (FPG) (Hb(A1c) + FPG) and a combination of FPG and 2-h plasma glucose (2hPG) (FPG + 2hPG); and (ii) whether substituting FPG + 2hPG with Hb(A1c) + FPG can enhance the detection of prediabetes in diabetes-free non-Hispanic Whites, non-Hispanic Blacks, and Mexican-Americans adults. METHODS: Data (n = 1376) from the 2007 to 2008 U.S. National Health and Nutrition Examination Surveys were used for this investigation. Prediabetes cut points were determined using 5.7-6.4%, 100-125, and 140-199 mg/dL for Hb(A1c), FPG, and 2hPG, respectively. Concordances between Hb(A1c) and FPG, Hb(A1c) and 2hPG, Hb(A1c) + FPG and FPG + 2hPG in screening for undiagnosed prediabetes were determined using sensitivity, specificity, and positive and negative likelihood ratios. RESULTS: The overall concordance between Hb(A1c) + FPG and FPG + 2hPG in screening for prediabetes was high, as indicated by a sensitivity of 92.4% (95% CI = 90.5-94.5) and specificity of 84.1% (81.2-87.0). The application of Hb(A1c) + FPG was associated with a higher prevalence of prediabetes compared to FPG + 2hPG. Compared with FPG + 2hPG, screening with Hb(A1c) + FPG was associated with 3.2%, 24.3%, and 4.2% relative increases in the identification of prediabetes in nondiabetic non-Hispanic Whites, non-Hispanic Blacks and Mexican-Americans, respectively. CONCLUSIONS: The enhanced prevalence of prediabetes using Hb(A1c) + FPG compared with FPG + 2hPG calls for the need to redefine at a more basic and practical level how to apply Hb(A1c) in screening for prediabetes. A redefined Hb(A1c) that incorporates FPG, age, race/ethnicity, and body mass index may be a better way to use Hb(A1c) in population-based and clinical settings.

Trends and clustering of cardiometabolic risk factors in American adolescents from 1999 to 2008.

AIM: To characterize trends and clustering of cardiometabolic risk factors in 12-17-year-old non-Hispanic white, non-Hispanic black (NHB), Mexican-American (MA), and multiracial American (MRA) adolescents. METHODS: Data from the 1999-2000 to 2007-2008 U.S. National Health and Nutrition Examination Surveys were used for this investigation. Clustering of cardiometabolic risk factors was determined using cardiometabolic risk factor clustering score (cMetS) computed by aggregating z scores of mean arterial blood pressure, triglycerides, fasting blood glucose, waist circumference, and high-density lipoprotein cholesterol. RESULTS: There were significant increases in waist circumference and high-density lipoprotein cholesterol, and decreases in low density lipoprotein cholesterol, triglycerides, and mean arterial blood pressure in the 10-year period between 1999-2000 and 2007-2008. There were gender and racial/ethnic differences in cMetS, with NHB having a more favorable cMetS for each studied time point. Overall, cMetS decreased by 93% in the 10-year period between 1999-2000 and 2007-2008. cMetS decreased by 98% and 77.3% for male and female adolescents, respectively, in the period between 1999-2000 and 2007-2008. With the exception of Mexican-American and multiracial American female adolescents, all racial/ethnic groups had improved cMetS values on comparing mean cMetS values of 1999-2000 with mean values of 2007-2008. Compared with other racial/ethnic groups, NHB male and female adolescents had the most improved cMetS. CONCLUSION: Because clustering of cardiometabolic risk factors is predictive of adult health status, early lifestyle intervention in adolescence may help slow down the progress and delay or prevent the onset of cardiovascular diseases in adulthood.

Validity of a continuous metabolic risk score as an index for modeling metabolic syndrome in adolescents.

PURPOSE: Although continuous values of metabolic syndrome risk scores (cMetS) has been suggested for modeling the association between potential risk factors and metabolic syndrome (MetS) in young people, the construct validity of cMetS has not been sufficiently examined in a representative sample of youngsters. This study examined: (i) sex and race/ethnic-specific optimal cut-off points of cMetS that are associated with MetS and (ii) the construct validity of cMetS in 12- to 19-year old non-Hispanic white (NHW), non-Hispanic black (NHB), and Mexican-American (MA) subjects. METHODS: Data (n = 1239) from the 2003 to 2004 and 2005 to 2006 National Health and Nutrition Examination Surveys were used in this study. cMetS was derived by aggregating age- and sex-standardized residuals of arterial blood pressure, triglycerides, glucose, waist circumference, and high-density lipoprotein cholesterol. Receiver operating characteristics analysis was used to determine the validity and performance of cMetS. The overall performance of the receiver operating characteristics test was quantified with area under the curve (AUC). RESULTS: A graded relationship between cMetS and increased number of MetS factors was observed, with MetS factors of 3 or greater yielding the greatest cMetS. In male adolescents, the optimal cMetS cut-off points of cMetS that are associated with MetS in NHW, NHB, and MA were 2.01, 2.45, and 2.34, respectively. The corresponding values in female adolescents for NBW, NHB, and MA were 1.93, 2.12, and 2.23, respectively. The construct validity of cMetS for MetS was high (AUC ≥0.885; sensitivity ≥66.7; specificity ≥74.8%). CONCLUSIONS: cMetS appears to be a suitable index for investigating the association between potential risk factors and MetS in adolescents. An understanding of the role of genetic and environmental risk factors in MetS in children may be enhanced with the use of cMetS.

Continuous metabolic syndrome risk score, body mass index percentile, and leisure time physical activity in American children.

The objective of this study was to determine independent and joint association of body mass index (BMI) percentile and leisure time physical activity (LTPA) with continuous metabolic syndrome (cMetS) risk score in 12- to 17-year-old American children. The 2003 to 2004 US National Health and Nutrition Examination Survey data were used for this investigation. LTPA was determined by self-report. cMetS risk score was calculated using standardized residuals of arterial blood pressure, triglycerides, glucose, waist circumference, and high-density lipoprotein cholesterol. Multiple linear regression analysis was used to evaluate association of BMI percentile and LTPA with cMetS risk score, adjusting for confounders. Increased BMI percentile and LTPA were each associated with increased and decreased cMetS risk score, respectively ((P<.01). There was a gradient of increasing cMetS risk score by BMI percentile cutpoints, from healthy weight (-0.77) to overweight (3.43) and obesity (6.40) ((P<.05). A gradient of decreasing cMetS risk score from sedentary (0.88) to moderate (0.17) and vigorous (-0.42) LTPA levels was also observed (P<.01). The result of this study suggests that promoting LTPA at all levels of weight status may help to reverse the increasing trends of metabolic syndrome in US children.