A Call to Action: Current Challenges and Considerations for COVID-19 Vaccination in Immunocompromised Populations.

The heightened risk of infection and complexities of preventing disease in immunocompromised individuals are at the forefront of public health strategies. The COVID-19 pandemic highlighted the increased vulnerability and susceptibility to serious outcomes in this population. COVID-19 prevention efforts led to the development of vaccines, including mRNA-based options, which were initially recommended as a 2-dose primary schedule for both immunocompromised and immunocompetent individuals. However, post-rollout assessments led to updated recommendations specific to immunocompromised populations. As COVID-19 potentially transitions to become endemic disease, immunocompromised individuals will remain at high risk of severe disease; thus, the evaluation of current vaccination challenges remains crucial for guiding effective public health efforts. This article summarizes key findings from the previous articles of this supplement, highlighting current vaccination challenges for at-risk immunocompromised groups and exploring solutions to ensure protection against COVID-19 for these vulnerable populations.

Global Safety Assessment of Adverse Events of Special Interest Following 2 Years of Use and 772 Million Administered Doses of mRNA-1273.

Background: Large-scale use of mRNA COVID-19 vaccines during the pandemic was associated with enhanced safety monitoring to ensure accurate and timely review of safety. We reviewed the mRNA-1273 (original strain) safety profile following 2 years of use (>772 million administered doses), primarily focusing on predefined safety topics (ie, adverse events of special interest [AESIs]) proposed in advance of COVID-19 vaccine use. Methods: Cumulative mRNA-1273 safety data were included from spontaneous adverse event (AE) cases reported to Moderna's global safety database between 18 December 2020 and 17 December 2022. Reporting rates of AESIs were calculated per 1 million doses of mRNA-1273 administered. Observed-to-expected (OE) ratios were computed by comparing observed rates of AESIs with the background/expected rate for these events to evaluate potential associations with mRNA-1273. Results: There were 658 759 identified case reports associated with 2 517 669 AEs. Most AEs were nonserious (83.4%; 2 098 954/2 517 669). Overall 0.7% (17 751/2 517 669) were fatal. AESIs represented 13.7% of all AEs (344 921/2 517 669), with reporting rates for most AESIs below the expected background incidence. Exceptions included anaphylaxis (OE ratio 3 days after vaccination, 2.09; 95% CI, 1.93-2.25) and, among individuals aged 12 to 40 years, myocarditis (OE ratio 7 days after any dose, 3.89 [3.50-4.32]; among men after dose 2, 8.57 [6.88-10.68]) and pericarditis (OE ratio 7 days after vaccination, 3.47; 2.89-4.16). Conclusions: This safety analysis of mRNA-1273 identified evidence of increased risk for anaphylaxis, myocarditis, and pericarditis but not for other AESIs identified for enhanced monitoring ahead of COVID-19 vaccine use.

Phase 3 trial to evaluate the safety, tolerability, and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, followed by 23-valent pneumococcal polysaccharide vaccine 6 months later, in at-risk adults 18-49 years of age (PNEU-DAY): A subgroup analysis by baseline risk factors.

Immunocompetent adults with certain medical and behavioral factors are at increased risk of pneumococcal disease. In some countries, sequential vaccination with 13-valent pneumococcal conjugate vaccine (PCV13) followed by 23-valent pneumococcal polysaccharide vaccine (PPSV23) is recommended for at-risk adults. This subgroup analysis from a phase 3 study evaluated the safety, tolerability, and immunogenicity of sequential administration of either V114 (a 15-valent PCV containing serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F, and 33F) or PCV13, followed 6 months later by PPSV23, in immunocompetent adults 18-49 years of age with pre-defined risk factors for pneumococcal disease. Safety and immunogenicity post-vaccination were analyzed by type and baseline number of risk factors for pneumococcal disease (1 and ≥2 risk factors). This analysis included 1,131 participants randomized 3:1 to receive either V114 or PCV13, followed by PPSV23. The majority (73.1%) of participants had at least one risk factor. Safety and tolerability profiles of V114 and PCV13 were similar across risk factor groups. V114 administered either alone or sequentially with PPSV23 6 months later was immunogenic for all 15 serotypes, including those not contained in PCV13, regardless of the number of baseline risk factors. V114 has the potential to broaden serotype coverage for at-risk adults.

When the Sailor's Handshake Fails: A Case of Syphilitic Hepatitis in an HIV Patient With Nonspecific Liver Biopsy and Atypical Cutaneous Presentation.

Secondary syphilis has variable systemic manifestations, impersonating the presentation of more common pathologies, deceiving clinicians, and creating a difficult-to-diagnose patient. The case discussed combines hepatic syphilis with an uncommon syphilitic dermatologic presentation in a patient with HIV and a history of hepatitis A and B. Due to the challenge of diagnosis, the relative ease of confirming the diagnosis with serological assays, and reversibility of hepatic injury, the inclusion of syphilitic hepatitis on a differential diagnosis of hepatitis is warranted.

Clinical and economic burden of HPV-related cancers in the US veteran population.

BACKGROUND: Human papillomavirus (HPV) is one of the most common sexually transmitted infection in the United States and can lead to cervical, vulvovaginal, anal, penile, and oropharyngeal cancers. Compared with the general population, US military members are at a higher risk of HPV-related conditions, yet vaccination rates are relatively low in this population. As many service members may not be diagnosed with HPV-related cancers until after they leave active service, the objective of this study was to determine the incidence, prevalence, and economic burden of HPV-related cancers among US veterans. METHODS: The study used the 2014-2018 Veterans Health Administration (VHA) database to identify newly diagnosed adult patients (cases) with HPV-related cancers, including cervical, vulvovaginal, anal, penile, and oropharyngeal cancers. Cases were matched by age, race, and sex to patients without HPV related cancer (controls). Outcome measures included annual incidence, prevalence, health care resource utilization (HCRU), and costs. These outcomes were calculated from the index date (first cancer diagnosis) through the earliest of 24 months, death, or end of study period. Adjusted results were examined using generalized linear models. RESULTS: The annual prevalence and incidence rates of HPV-related cancers ranged from 43 (anal) to 790 (oropharyngeal) cases per million (CPM), and four (anal) to 131 (cervical) CPM, respectively. Compared with controls, cases had significantly higher annual HCRU. Mean numbers of annual inpatient hospitalizations were several times higher compared to controls (cervical: 6.7-times (×); vulvovaginal: 2.7×; penile: 6.6×; oropharyngeal: 10.2×; and anal: 14.9×; all p < 0.01). Similarly, cases had significantly higher all-cause healthcare costs vs. matched controls across all cancer types: cervical ($24,252 vs. $10,402), vulvovaginal ($34,801 vs. $10,913), penile ($42,772 vs. $9,139), oropharyngeal ($82,763 vs. $10,017), and anal ($98,146 vs. $8,339); (all p < 0.01). CONCLUSIONS: HPV-related cancers may cause significant clinical and economic burden within the VHA system. Given the consequences of HPV-related cancers among veterans who did not have access to the vaccine, HPV vaccination of active military and eligible veterans should be considered a healthcare priority.

Sedation assessment using the Ramsay scale.

Patients undergoing sedation in emergency departments (EDs) must be monitored carefully to ensure that, when they are being transferred to different departments, they are safe and that information about them is accurate. However, sedation scoring, for which several tools are available, should not be confused with assessment of consciousness, which is undertaken using the Glasgow Coma Scale. This article considers the validity and reliability of sedation scoring tools, and discusses how ED staff can choose and integrate them into patient care pathways.

The Role of the General Practitioner in Evaluation and Treatment of Girls with Menstrual-Related Complaints.

A common scenario a pediatrician or general practitioner may encounter in the care of adolescent girls is menstrual concerns. A frequent complaint may be of irregular periods that may be coming twice a month or possibly only every other month. Sometimes the teenage patient may complain of heavy bleeding or prolonged periods lasting longer than 7 days. The typical patient with this complaint could be a 14-year-old girl with periods that started at age 13 years who has had no periods for 3 months after onset of menarche. However, once the second period comes, the patient complains of periods happening often, lasting for 5 days, and with the need to change feminine products about 3 times per day. She is otherwise healthy with no medical issues and no surgeries. The family may question if this is considered normal or if something is potentially wrong with the adolescent's pubertal development. [Pediatr Ann. 2019;48(5):e187-e189.].

Birth Control Management for the Primary Care Provider.

Contraceptive management is occurring more frequently in the primary care setting. Pediatricians should be familiar with the most common methods of contraception due to the fact that families are comfortable seeking care for their adolescents at the primary care office for these types of concerns. Contraceptive methods are often used for noncontraceptive benefits as well, which makes it even more important to feel comfortable prescribing contraceptives at pediatricians' offices. [Pediatr Ann. 2019;48(2):e51-e55.].

The Truth About Obesity, Exercise, and Nutrition.

There is a plethora of misinformation regarding obesity, diet, and exercise due to lack of supporting evidence on these topics. There are myths and facts about what exactly encompasses a healthy lifestyle that interfere with the ability to lose weight and stay healthy. These include topics such as the effects of small sustained increases in energy intake or expenditure, establishment of realistic goals, rapid weight loss, readiness for weight loss, physical activity, breast-feeding as well as the effects of eating breakfast daily, early childhood experiences, eating fruits and vegetables, weight that cycles up and down, snacking, and the environment. There are evidence-based approaches that can help guide people in their pursuit of a healthy lifestyle, weight loss, and physical activity. Pediatricians and health care providers should be aware of these approaches when counseling patients on a healthy lifestyle. [Pediatr Ann. 2018;47(11):e427-e430.].

Depression in Children and Adolescents: The Pediatrician at the Front Lines.

Pediatricians are the primary care providers for most children and adolescents in the United States, so they need to feel comfortable caring for children and teens with depression. This topic is an extremely important one because the top three reasons teens die or get injured are related to accidents (3.7 per 100,000 for those ages 5-14 years and 28.5 per 100,000 for those ages 15-24 years), suicide (1 per 100,000 in the younger age group, and 12.5 deaths per 100,000 in those ages 5-14 years), and homicide (0.7 per 100,000 in those age 5-14 years, and 10.8 per 100,000 in those age 15-24 years). Each year, 21% of children ages 9 to 17 years are diagnosed with a mental or addictive disorder associated with at least minimum impairment, with 11% of these children having significant functional impairment and another 5% demonstrating extreme functional impairment. We know that one-half of all lifetime cases of mental health disorders start by age 14 years. This includes serious adult psychiatric illnesses such as major depressive disorder, anxiety disorders, and substance abuse. Three-quarters are present by age 24 years; therefore, interventions aimed at prevention or early treatment need to focus on youth. [Pediatr Ann. 2018;47(7):e261-e265.].

Adolescent Sexual Health and Education: Where Does the Pediatrician's Responsibility Fall?

Adolescence is a stressful time with a considerable amount of change, not only physically, with all the changes expected throughout puberty, but also emotionally, spiritually, and psychosocially. Teens are learning how to build and sustain relationships, learning boundaries in all areas of their lives, experimenting, as well as setting values that will sustain them throughout their lives. Home, school, various social settings, and places of worship all contribute to where adolescents learn what their values are, what they want their values to be, and how they start to make choices about their personal beliefs, which may not always align with their family values. Adolescents spend most of their time in school, so the classroom is a logical place where certain discussions, such as puberty and sexuality, should happen regarding changes that are occurring with their bodies. The home environment, as well as the willingness of parents to have open, honest dialogue about sexual education, is also a vital component of ensuring that adolescents feel safe to openly discuss this topic. Pediatric clinicians also play an important role in helping to inform adolescents and their families about sexual health and development. [Pediatr Ann. 2018;47(4):e136-e139.].

Improving human papilloma virus vaccination rates throughout military treatment facilities.

OBJECTIVES: The four objectives of this study were to (1) educate military healthcare providers on HPV disease and vaccine, (2) assess short term recall of information presented at educational sessions, (3) assess provider comfort level with the vaccine, and (4) assess improvement in HPV vaccination rates. METHODS: Standardized interactive educational sessions were conducted at military primary care clinics with pre- and post-educational quizzes administered before and immediately following the sessions. Provider attitudes were assessed using Likert scale questionnaires. Vaccination rates in children and young adolescents ages 11-18 at one of the participating regions that had a champion and started a Quality Improvement (QI) project were assessed at baseline, at 3-months and at 6-months post sessions. RESULTS: 200 providers were reached at 48 primary care clinics during May 2014 through October 2015 with 200 quizzes and Likert scale questionnaires returned. There was increase in knowledge following the educational sessions as revealed in the pre- and post- test scores [t(57) = -5.04, p < 0.001]. There was a significant overall increase in comfort in answering patients' and parents' questions about HPV vaccine [p = 0.003]. There was a significant increase in the number of vaccines given at all the clinics 3-months after the educational sessions at the region who had a champion dedicated to monitoring vaccine rates and ensuring implementation efforts [p = 0.01] and started a QI project. This increase was not sustained at 6-months [p = 0.324]. CONCLUSIONS: Improvement in provider short term knowledge recall and comfort level in answering parents' questions was seen. We found that educational sessions can improve HPV vaccination rates in military clinics that have a vaccine champion for up to 3-months. Further research into the effects of having clinic vaccine champions is critical.

Outcomes of an Adolescent School-Based Health Initiative Needs Assessment.

Adolescent School-Based Health Initiatives (ASBHIs) are designed to increase adolescent access to medical homes and services that are not otherwise available without significant barriers. ASBHIs have been proven to increase access to care for school-aged adolescents with unique needs and limited access to these much-needed medical services. For this descriptive study we conducted a needs assessment to understand and determine the needs and desires for a school-based health initiative in a middle school in the community. Survey topics included demographics, health care needs, and desired health resources. Most teachers (94%) and parents (83%) indicated that they would encourage their student/child to participate in an ASBHI program, and 57% of students reported that they would use an ASBHI program. Both parents (71%) and teachers (94%) indicated that student attendance would improve with an Adolescent School-Based Health Initiative. There is sufficient evidence for the need and utilization of an ASBHI program in this community.

Talking to Adolescents About Social Media.

I see a large number of adolescents in my clinic with issues related to their social media use. These issues range from lack of sleep, to depression, to cyberbullying, and even sex trafficking, all secondary to constant social media exposure. Pediatricians should ask about social media use when they see children and adolescents who already have access to electronic devices. They should also ask parents about controls that are set in place to monitor social media use, content, and friend connections on those sites. They should ensure that their children know personally everyone they are connected to on social media and that their accounts are always private and not public. This will help reduce many of the issues associated with the potential consequences of social media use. [Pediatr Ann. 2017;46(8):e274-e276.].

Addressing Eating Disorders and Weight Control in Children and Adolescents.

How often do we look at a patient's body mass index (BMI) and only make a comment if the BMI is above normal in the overweight or obese category? As pediatricians, we often do not give it a second thought when the BMI is normal, and we generally do not counsel on healthy eating practices in these cases. However, when people are overweight, obese, and sometimes even normal weight they are told by family, friends, as well as physicians that they need to either not gain any more weight, or that they need to lose weight. As clinicians, we should be aware that comments like that may trigger a disordered pattern of eating for some people, which can lead to an eating disorder. [Pediatr Ann. 2017;46(5):176-e179.].

The Impact of Service Dogs on Engagement in Occupation among Females with Mobility Impairments: A Qualitative Descriptive Study.

It is becoming more common for people with disabilities to procure service dogs as a form of assistive technology (AT). However, there is little qualitative research examining the impact of service dogs on engagement in valued daily activities (occupations) among persons with mobility impairments. This study used a qualitative descriptive methodology to learn about the experiences of four female service dog owners with mobility impairments, with a focus on the impact of service dog use on the performance of daily occupations and participation in social activities, and their experiences utilizing a service dog as a form of AT. Data analysis indicated that each participant's service dog made a significant impact on their everyday lives and their ability to independently perform everyday activities; however, there are also unique challenges associated with service dog ownership that must be considered when evaluating benefits of service dog partnership. Overall, the positive outcomes reported by participants indicate that service dogs can be considered a beneficial, adaptable form of AT for some persons with mobility impairments.

School-Based Health Center Model Within the Military Health System: The Role of the Adolescent Medicine Physician.

Adolescents are less motivated to seek medical care for various reasons. Within the military health care system, access barriers, although less encountered, can still be a burden not only to the adolescent, but also the school system. This article describes the development of a school-based health center within a school district on a military installation. The school clinic was created by adolescent medicine specialists to maximize access to care. Students of adolescent age utilized the clinic for evaluation of acute and chronic conditions, preventative services, preparticipation evaluation, and other general complaints. After receiving signed consent forms, 30% of students were eligible for health care. There was minimal cost to initiate the service. Development of school-based health center programs at other military installations could potentially improve the status of the military health system during a time of high stress among military dependents.