RESUMEN
A series of oxygenated cholesterol derivatives were prepared from new synthetic methods and evaluated for their in vitro antimicrobial properties against human pathogens. The activity was highly dependent on the structure of the different compounds involved. The best results were obtained with hydroxy ketones 2, 4 and 5 and diketone 7 exhibiting activities against S. cerevisiae (ATCC 28383) and Candida albicans (CIP 1663-86). For example, compound 2 exhibited high activities against C. albicans (CIP 1663-86) and Amphotericine B and miconazole resistant strain C. albicans (CIP 1180-79) at a concentration of 1.5 microg/mL.
Asunto(s)
Antifúngicos/síntesis química , Colesterol/síntesis química , Colesterol/farmacología , Anfotericina B/farmacología , Antifúngicos/farmacología , Candida albicans/efectos de los fármacos , Resistencia a Medicamentos , Humanos , Cetonas , Miconazol/farmacología , Oxígeno/química , Saccharomyces cerevisiae/efectos de los fármacos , Relación Estructura-ActividadRESUMEN
A series of hydrazones synthesized from various cholesterol derivatives were evaluated for their in vitro antimicrobial properties against human pathogens. The activity was highly dependent on the structure of the different compounds involved. The best results have been obtained with tosylhydrazone cholesterol derivatives 8 and 9 exhibiting activities against Candida albicans (CIP 1663-80) at a concentration of 1.5 microg/ml.
Asunto(s)
Antifúngicos/síntesis química , Colesterol/análogos & derivados , Hidrazonas/síntesis química , Antibacterianos/síntesis química , Antibacterianos/farmacología , Antifúngicos/farmacología , Colesterol/síntesis química , Colesterol/farmacología , Hidrazonas/farmacologíaRESUMEN
The volatile oils of the aerial parts and roots from a pasture plant, Elionurus elegans, were studied by GC-MS analyses. Both organs studied contained only terpenic constituents. The main components found in the extract essential oils of the aerial parts were campherenone (43.0%), caryophyllene oxide (4.9%), and bisabolone (4.9%), whereas those found in the root essential oils were campherenone (39.0%), epi-beta-santalene (12.0%), and caryophyllene oxide (4.6%). Furthermore, the oils were tested for antibacterial and antifungal activities. The results obtained led to a nonsignificant inhibitory effect, although an increase of the lag stage was shown for the kinetics growth of Candida albicans, Saccharomyces cerevisiae, Enterococcus hirae, and Staphylococcus aureus. When alpha-tocopherol is used as a control, the antioxidant activities of the oils obtained from the aerial parts and roots were 30 and 46% IC(50), respectively.
Asunto(s)
Aceites Volátiles/química , Poaceae/química , Antioxidantes/farmacología , Candida albicans/efectos de los fármacos , Candida albicans/crecimiento & desarrollo , Enterococcus/efectos de los fármacos , Enterococcus/crecimiento & desarrollo , Cromatografía de Gases y Espectrometría de Masas , Aceites Volátiles/farmacología , Extractos Vegetales/química , Extractos Vegetales/farmacología , Aceites de Plantas/química , Raíces de Plantas/química , Saccharomyces cerevisiae/efectos de los fármacos , Saccharomyces cerevisiae/crecimiento & desarrollo , Staphylococcus aureus/efectos de los fármacos , Staphylococcus aureus/crecimiento & desarrollo , Terpenos/análisisRESUMEN
The essential oil of Artemisia annua aerial parts, consisting of camphor (44%), germacrene D (16%), trans-pinocarveol (11%), beta-selinene (9%), beta-caryophyllene (9%) and artemisia ketone (3%), was screened for its antimicrobial activity. The essential oil remarkably inhibited the growth of tested Gram-positive bacteria Enterococcus hirae and both tested fungi. This oil has shown an antioxidant activity equivalent to 18% of the reference compound (alpha-tocopherol).