RESUMEN
Quaternary ammonium compounds (QACs), a large class of chemicals that includes high production volume substances, have been used for decades as antimicrobials, preservatives, and antistatic agents and for other functions in cleaning, disinfecting, personal care products, and durable consumer goods. QAC use has accelerated in response to the COVID-19 pandemic and the banning of 19 antimicrobials from several personal care products by the US Food and Drug Administration in 2016. Studies conducted before and after the onset of the pandemic indicate increased human exposure to QACs. Environmental releases of these chemicals have also increased. Emerging information on adverse environmental and human health impacts of QACs is motivating a reconsideration of the risks and benefits across the life cycle of their production, use, and disposal. This work presents a critical review of the literature and scientific perspective developed by a multidisciplinary, multi-institutional team of authors from academia, governmental, and nonprofit organizations. The review evaluates currently available information on the ecological and human health profile of QACs and identifies multiple areas of potential concern. Adverse ecological effects include acute and chronic toxicity to susceptible aquatic organisms, with concentrations of some QACs approaching levels of concern. Suspected or known adverse health outcomes include dermal and respiratory effects, developmental and reproductive toxicity, disruption of metabolic function such as lipid homeostasis, and impairment of mitochondrial function. QACs' role in antimicrobial resistance has also been demonstrated. In the US regulatory system, how a QAC is managed depends on how it is used, for example in pesticides or personal care products. This can result in the same QACs receiving different degrees of scrutiny depending on the use and the agency regulating it. Further, the US Environmental Protection Agency's current method of grouping QACs based on structure, first proposed in 1988, is insufficient to address the wide range of QAC chemistries, potential toxicities, and exposure scenarios. Consequently, exposures to common mixtures of QACs and from multiple sources remain largely unassessed. Some restrictions on the use of QACs have been implemented in the US and elsewhere, primarily focused on personal care products. Assessing the risks posed by QACs is hampered by their vast structural diversity and a lack of quantitative data on exposure and toxicity for the majority of these compounds. This review identifies important data gaps and provides research and policy recommendations for preserving the utility of QAC chemistries while also seeking to limit adverse environmental and human health effects.
Asunto(s)
COVID-19 , Desinfectantes , Humanos , Compuestos de Amonio Cuaternario/química , Pandemias , AntibacterianosRESUMEN
1,4-Dioxane is a persistent and mobile organic chemical that has been found by the United States Environmental Protection Agency (USEPA) to be an unreasonable risk to human health in some occupational contexts. 1,4-Dioxane is released into the environment as industrial waste and occurs in some personal-care products as an unintended byproduct. However, limited exposure assessments have been conducted outside of an occupational context. In this study, the USEPA simulation modeling tool, Stochastic Human Exposure and Dose Simulator-High Throughput (SHEDS-HT), was adapted to estimate the exposure and chemical mass released down the drain (DTD) from drinking water consumption and product use. 1,4-Dioxane concentrations measured in drinking water and consumer products were used by SHEDS-HT to evaluate and compare the contributions of these sources to exposure and mass released DTD. Modeling results showed that compared to people whose daily per capita exposure came from only products (2.29 × 10-7 to 2.92 × 10-7 mg/kg/day), people exposed to both contaminated water and product use had higher per capita median exposures (1.90 × 10-6 to 4.27 × 10-6 mg/kg/day), with exposure mass primarily attributable to water consumption (75-91%). Last, we demonstrate through simulation that while a potential regulatory action could broadly reduce DTD release, the proportional reduction in exposure would be most significant for people with no or low water contamination.
Asunto(s)
Agua Potable , Contaminantes Químicos del Agua , Dioxanos/análisis , Exposición a Riesgos Ambientales/análisis , Humanos , Compuestos Orgánicos , Medición de Riesgo , Estados Unidos , Contaminantes Químicos del Agua/análisisRESUMEN
Surfactants are high production volume chemicals used in numerous domestic and industrial applications and, after use, the most abundant organic contaminants in wastewater. Their discharge might jeopardize the receiving aquatic ecosystems, including sediments, where they tend to accumulate. This is the first comprehensive study on their distribution and fate in this environmental compartment as we performed simultaneous analysis of the three main classes of surfactants (anionic: LAS; nonionic: NPEO and AEO; cationic: DTDMAC, DADMAC, BAC, and ATMAC) and some of their transformation products (SPC, NP, NPEC, and PEG). To account for spatial and time trends, surface sediments and dated cores were collected from Jamaica Bay, a heavily sewage-impacted estuary in New York City. The concentrations of surfactants in surface sediments were between 18 andâ¯>â¯200⯵gâ¯g-1 and showed slight variation (<10%) over different sampling years (1998, 2003 and 2008). Cationic surfactants were found at the highest concentrations, with DTDMAC accounting for between 52 and 90% of the total sum of target compounds. Vertical concentration profiles in dated cores from the most contaminated station, in the vicinity of the biggest local sewage treatment plant (STP), indicated two sub-surface surfactant peaks in the mid-1960s (469⯵gâ¯g-1) and late 1980s (572⯵gâ¯g-1) coinciding with known STP upgrades. This trend was observed for most target compounds, except for DADMAC, C22ATMAC, and PEG, which showed a continuous increase towards the top of the cores. In-situ degradation was studied by comparing sediment core samples taken 12 years apart (1996 and 2008) and revealed a net decrease in PEG and specific surfactants (BAC, ATMAC, NPEO, and AEO) accompanied by growing concentrations of metabolites (SPC, NP, and NPEC). DTDMAC, DADMAC, and LAS, however, remained stable over this period, suggesting recalcitrant behavior under the anaerobic conditions in Jamaica Bay sediments. MAIN FINDING: Chronology of major synthetic surfactants are illustrated in the dated sediment cores, as well as their different diagenetic fates.