The influence of selected personal and environmental factors on leisure activities in adults with cerebral palsy.

PURPOSE: This study examined the influence of selected personal and environmental factors on leisure participation in adults with cerebral palsy (CP). METHODS: A group of 145 adults with CP (18-41 years old, 51% male) responded to questionnaires regarding 1) socio-demographic and health factors, 2) life habits (Life-H: short version 3.1) and 3) the environment (Measure of the Quality of the Environment: version 2.0). A chi2 statistic (p<0.05) estimated the association between 1) socio-demographic and health factors and the environment and 2) the level of leisure activity participation. RESULTS: Most participants (mean age=28 years) lived with their parents. Leisure activities were their principal occupation. Mobility and participation were positively associated. The environment (e.g. accompanying services, adapted transport, cultural services and computers) facilitated leisure for those with a high or moderate participation level. Individuals with low participation perceived the environment as having no influence. CONCLUSIONS: Adults with CP who are more mobile participate more in leisure activities. A positive perception of the environment (facilitating leisure participation) likely reflects the individual's ability to benefit from the environment, whereas a neutral view of the environment may reflect the fact that other factors, such as mobility limitations, are of greater relevance to leisure participation.

Gait Training after Stroke on a Self-Paced Treadmill with and without Virtual Environment Scenarios: A Proof-of-Principle Study.

Purpose: The purpose of this proof-of-principle study was to show that virtual reality (VR) technology could be coupled with a self-paced treadmill to further improve walking competency in individuals with chronic stroke. Method: A 62-year-old man with a chronic right hemispheric stroke participated in a treadmill walking programme involving first a control (CTL) protocol, then VR training. In CTL training, he walked without time constraints while viewing still pictures and reacting to treadmill movements similar to those that he would have experienced later in VR training. In VR training, he experienced treadmill movements programmed to simulate changes encountered in five virtual environments rear-projected onto a large screen. Training difficulty in nine sessions over 3 weeks was increased by varying the time constraints, terrain surface changes, and obstacles to avoid. Effects on walking competency were assessed using clinical measures (5 m walk test, 6 min walk test, Berg Balance Scale, Activities-specific Balance Confidence scale) and questionnaires (Assessment of Life Habits Scale and personal appraisal). Results: CTL and VR training resulted in a similar progression through the training sessions of total time walked on the treadmill. The VR training led to an additional increase in speed as measured by walking 5 metres as fast as possible and distance walked in 6 minutes, as well as improved balance self-efficacy and anticipatory locomotor adjustments. As reported by the participant, these improved outcomes transferred to real-life situations. Conclusions: Despite the limited potential for functional recovery from chronic stroke, an individual can achieve improvements in mobility and self-efficacy after participating in VR-coupled treadmill training, compared with treadmill training with the same intensity and surface perturbations but without VR immersion. A larger scale, randomized controlled trial is warranted to determine the efficacy of VR-coupled treadmill training for mobility intervention post-stroke.

Objectif : la présente étude de validation visait à démontrer que la réalité virtuelle (RV) peut être jumelée à un tapis roulant autocontrôlé pour améliorer l'aptitude à marcher des personnes ayant un accident vasculaire cérébral (AVC) chronique. Méthodologie : un homme de 62 ans ayant un AVC chronique de l'hémisphère droit a participé à un programme de marche sur tapis roulant, d'abord au moyen d'un protocole de contrôle (CTL), puis d'un entraînement en RV. Pendant l'entraînement CTL, l'homme a marché sans contrainte de temps tout en regardant des images fixes et en réagissant aux mouvements du tapis roulant semblables à ceux repris par la suite en RV. Pendant l'entraînement en RV, il a ressenti les mouvements du tapis roulant programmés pour simuler les changements observés dans cinq environnements virtuels rétroprojetés sur grand écran. La difficulté de l'entraînement au cours de neuf séances réparties sur trois semaines a augmenté en variant les contraintes de temps, les changements de surface du terrain et les obstacles à éviter. Les chercheurs ont évalué les effets sur l'aptitude à marcher à l'aide de mesures cliniques (tests de marche de cinq mètres et de six minutes, échelle d'évaluation de l'équilibre de Berg, échelle de confiance en l'équilibre pendant des activités) et de questionnaires (échelle d'évaluation des habitudes de vie et évaluation personnelle). Résultats : l'entraînement CTL et celui en RV ont suscité une progression similaire de la durée totale de marche sur le tapis roulant pendant les séances d'entraînement. L'entraînement en RV a favorisé une amélioration supplémentaire de la marche rapide sur cinq mètres et de la distance parcourue en six minutes, de même qu'une meilleure auto-efficacité de l'équilibre et de meilleurs ajustements locomoteurs anticipés. Comme l'a indiqué le participant, cette amélioration des résultats se transposait dans la vie quotidienne. Conclusions : malgré le potentiel limité de récupération fonctionnelle en cas d'AVC chronique, une personne peut améliorer sa mobilité et son auto-efficacité après avoir participé à un entraînement sur tapis roulant jumelé à la RV, par rapport à un entraînement sur tapis roulant de la même intensité et selon les mêmes perturbations de la surface du sol, mais sans l'immersion de la RV. Un essai aléatoire et contrôlé à plus vaste échelle s'impose pour déterminer l'efficacité de l'entraînement sur tapis roulant jumelé à la RV dans le cadre d'une intervention de mobilité après un AVC.

Communicating a diagnosis of cerebral palsy: caregiver satisfaction and stress.

As part of the implementation of a population-based registry of children with cerebral palsy, caregiver satisfaction with the process by which diagnosis was originally communicated by a professional was assessed. Satisfaction with various aspects of the diagnosis process was assessed using a five-point Likert scale and related to child, family, and situational characteristics. Measures were then correlated with current caregiver stress as measured objectively by the Parenting Stress Inventory. During the registration process, 59 consecutive caregivers (55 mothers) were questioned. Overall, 62% (35/59) were satisfied with the disclosure process, with satisfaction ranging from 69% (41/59-hopefulness) to 92% (54/59-honesty) for professional qualities, and from 61% (36/59-sufficient information provided) to 78% (46/59-understandable) for disclosure content. Satisfaction was related to the quantity and content of information given at the disclosure session. Parenting Stress Inventory scores, both total and for parental distress, correlated significantly with both the severity of the child's cerebral palsy and caregiver satisfaction with varying elements of the disclosure process. Overall caregiver satisfaction with the process by which a diagnosis of cerebral palsy is given appears to be good. Together with the severity of a child's intrinsic cerebral palsy, it appears to relate to later parental adjustment to a setting of chronic disability, suggesting a portal through which improvements in information delivery may result in better familial adaptation to disability.

Accuracy of a pharmacovigilance algorithm in diagnosing drug hypersensitivity reactions.

BACKGROUND: This study was performed to evaluate the diagnostic accuracy of a pharmacovigilance algorithm in patients with 1 or more histories suggestive of drug hypersensitivity. METHODS: We performed a retrospective analysis of a clinic case series. We analyzed patients with suspected clinical reactions of drug hypersensitivity. Patients with severe skin reactions were excluded. Patients with history of drug allergy were subjected to additional testing to validate this history. Following a detailed clinical history, skin tests were performed. If skin tests were not available or validated, drug provocation tests were conducted. Assessment of causality was established by an investigator unaware of drug testing results using a pharmacovigilance algorithm that was then compared with the final diagnosis. RESULTS: A total of 677 consecutive patients with 1001 reactions were analyzed. No score could be given because of the absence of 1 of the criteria required for 204 reactions (20.4%). For 720 reactions (71.9%), a dubious causality assessment score was given. Drug hypersensitivity was confirmed by drug testing in 175 reactions (17.5%) and eliminated in 826 reactions (82.5%). Sensitivity of the algorithm was 10.3% and specificity was 76.9%. Although there were 1.7% false-positive scores, there were no false-negative scores. The logistic regression that was performed to look for independent clinical risk factors linked to the drug hypersensitivity diagnosis found 3 parameters: likely causality assessment score, drug reintroduction in clinical history, and delay between reaction and last drug intake of less than 1 hour. CONCLUSION: A pharmacovigilance algorithm is not accurate for the diagnosis of drug hypersensitivity reactions and cannot replace drug allergy testing.

The role of technology in task-oriented training in persons with subacute stroke: a randomized controlled trial.

This trial compares the effects of task-oriented physical therapy (PT) provided with and without the use of rehabilitation technology on locomotor recovery in 63 persons with subacute stroke. Participants in the experimental (EXP) group used a treadmill, a Kinetron isokinetic exerciser, and a limb-load monitor, whereas those in the control (CTL) group did not while engaging in PT 1 h per day, 5 days per week for 2 months. Locomotor recovery was assessed by clinical (gait speed, Fugl Meyer motor leg and arm subscores, the Balance Scale, the Timed Up and Go, and the Barthel ambulation subscore) and laboratory outcomes (gait kinematics and kinetics) pre- and posttherapy and 3 months later. Within groups, gait speed (P < 0.01) and all secondary measures improved posttherapy (P < 0.01-0.05), and improvements in clinical measures were maintained at follow-up, but there was no difference between groups (P > 0.05). When the groups were pooled, the increase in gait speed was associated (r = 0.52, P = 0.003) with an increase in ankle power generation of the affected leg. The results demonstrate that the efficacy of the task-oriented approach is not dependent on rehabilitation technology.

Measuring steady-state oxygen uptake during the 6-min walk test in adults with cerebral palsy: feasibility and construct validity.

This study evaluated the feasibility of measuring steady-state oxygen uptake (VO2) during the 6-min walk test (6MWT) in adults with cerebral palsy (CP) who walk without support and whether there is construct validity for net 6MWT VO2 as a measure of their walking ability. Cardiorespiratory variables were assessed at rest and during the 6MWT in 15, independently ambulatory adults, 21-41 years old, with CP. The Gross Motor Function Measure dimensions D and E (GMFM-D and GMFM-E) quantified walking-related skills. Steady-state VO2 was achieved during the 6MWT. After controlling for body mass and speed, the net 6MWT VO2 was strongly related to GMFM-D (r=-0.58, ρ=0.03) and GMFM-E scores (r=-0.66, ρ=0.007). We conclude that for young adults with CP who walk without support, it is feasible to measure steady-state VO2 during the 6MWT and that the net 6MWT VO2 has construct validity as a measure of walking ability.

Factors related to physical activity in adults with cerebral palsy may differ for walkers and nonwalkers.

OBJECTIVE: To explore what factors besides walking ability, e.g., additional health problems or complications, general health, and sociodemographic status, may be related to physical activity in adults with cerebral palsy. DESIGN: We administered a questionnaire regarding sociodemographic and health-related factors of potential relevance to physical activity to 66 men (20-41 yrs) and 66 women (18-39 yrs) with various types of cerebral palsy. Data were analyzed using logistic regression. RESULTS: Use of walking as the primary means of self-transport (walking ability) was associated with a higher odds of being physically active (odds ratio = 3.75; P = 0.002). Among those who could walk, being younger and having a positive perception of health were also associated with a higher odds of being active (odds ratios of 2.6 and 3.0, respectively). This was not true among nonwalkers. For individuals who walked, inactivity was associated with an increase in the severity (during the past 3 yrs) of several additional health problems or complications. For the nonwalkers, inactivity was most clearly associated with perceived range-of-motion limitations. CONCLUSIONS: Among adults with cerebral palsy, the ability to walk, as expected, is associated with being physically active. The factors additionally related to physical activity differ between walkers and nonwalkers.

Impaired viscoelastic behaviour of spastic plantarflexors during passive stretch at different velocities.

OBJECTIVE: The aim of this study was to evaluate the effect of velocity on non-reflexly induced resistive torque (RT) responses of the spastic plantarflexors (PFs) of subjects with spinal cord injuries. DESIGN: Descriptive study, transversal. BACKGROUND: In spastic muscles, non-reflex changes such as increased muscle stiffness, contractures and atrophy have been reported. These changes probably alter muscle tensile properties and viscoelastic behaviour. METHODS: Six subjects with chronic (1-3 yr) spinal cord injuries (SCI) and 12 normal controls (CTLs) participated in this study. Passive ankle dorsiflexions (DFs), ranging from -35 degrees to 5 degrees of DF, were randomly imposed at 5 degrees /s, 10 degrees /s, 20 degrees /s, 40 degrees /s, 60 degrees /s, 120 degrees /s and 180 degrees /s using an isokinetic dynamometer (Kin-Com(TM)). Unwanted muscle activity was detected using surface electrodes on the soleus and tibialis anterior muscles. RESULTS: The results show first that RT rose with increasing velocity; the RT increment reached statistical (analysis of variance (ANOVA); Scheffé post-hoc procedure) significance (P < 0.01) at a lower velocity for the CTLs (40 degrees /s) group than for the SCI group (60 degrees /s). Second, significantly (t-test; P < 0.001) larger net increments of RT (RT at each velocity minus RT at 5 degrees /s) were found for the CTLs at 180 degrees /s than for the SCI group whose RT plateaued at 60 degrees /s. Finally, whereas the RT-velocity relationship was linear (r = 0.94) in the CTLs, that of the SCI group followed a power regression model (r = 0.85). CONCLUSIONS: These results show that the spastic PFs of the subjects with SCIs have an impaired velocity-sensitive behaviour, especially at high velocities of stretch where greater resistance is expected.

Brain activations during motor imagery of locomotor-related tasks: a PET study.

Positron emission tomography (PET) was used to study the involvement of supraspinal structures in human locomotion. Six right-handed adults were scanned in four conditions while imagining locomotor-related tasks in the first person perspective: Standing (S), Initiating gait (IG), Walking (W) and Walking with obstacles (WO). When these conditions were compared to a rest (control) condition to identify the neural structures involved in the imagination of locomotor-related tasks, the results revealed a common pattern of activations, which included the dorsal premotor cortex and precuneus bilaterally, the left dorsolateral prefrontal cortex, the left inferior parietal lobule, and the right posterior cingulate cortex. Additional areas involving the pre-supplementary motor area (pre-SMA), the precentral gyrus, were activated during conditions that required the imagery of locomotor movements. Further subtractions between the different locomotor conditions were then carried out to determine the cerebral regions associated with the simulation of increasingly complex locomotor functions. These analyses revealed increases in rCBF activity in the left cuneus and left caudate when the W condition was compared to the IG condition, suggesting that the basal ganglia plays a role in locomotor movements that are automatic in nature. Finally, subtraction of the W from the WO condition yielded increases in activity in the precuneus bilaterally, the left SMA, the right parietal inferior cortex and the left parahippocampal gyrus. Altogether, the present findings suggest that higher brain centers become progressively engaged when demands of locomotor tasks require increasing cognitive and sensory information processing.