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1.

The expanding amyloid family: Structure, stability, function, and pathogenesis.

Sawaya, Michael R; Hughes, Michael P; Rodriguez, Jose A; Riek, Roland; Eisenberg, David S.

Cell ; 184(19): 4857-4873, 2021 09 16.

Artículo en Inglés | MEDLINE | ID: mdl-34534463

2.

Structural Studies of Amyloid Proteins at the Molecular Level.

Eisenberg, David S; Sawaya, Michael R.

Annu Rev Biochem ; 86: 69-95, 2017 06 20.

Artículo en Inglés | MEDLINE | ID: mdl-28125289

3.

How Hard It Is Seeing What Is in Front of Your Eyes.

Eisenberg, David S.

Cell ; 174(1): 8-11, 2018 06 28.

Artículo en Inglés | MEDLINE | ID: mdl-29958112

4.

Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.

Jiang, Yi Xiao; Cao, Qin; Sawaya, Michael R; Abskharon, Romany; Ge, Peng; DeTure, Michael; Dickson, Dennis W; Fu, Janine Y; Ogorzalek Loo, Rachel R; Loo, Joseph A; Eisenberg, David S.

Nature ; 605(7909): 304-309, 2022 05.

Artículo en Inglés | MEDLINE | ID: mdl-35344984

5.

The amyloid state of proteins in human diseases.

Eisenberg, David; Jucker, Mathias.

Cell ; 148(6): 1188-203, 2012 Mar 16.

Artículo en Inglés | MEDLINE | ID: mdl-22424229

6.

Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.

Kato, Masato; Han, Tina W; Xie, Shanhai; Shi, Kevin; Du, Xinlin; Wu, Leeju C; Mirzaei, Hamid; Goldsmith, Elizabeth J; Longgood, Jamie; Pei, Jimin; Grishin, Nick V; Frantz, Douglas E; Schneider, Jay W; Chen, She; Li, Lin; Sawaya, Michael R; Eisenberg, David; Tycko, Robert; McKnight, Steven L.

Cell ; 149(4): 753-67, 2012 May 11.

Artículo en Inglés | MEDLINE | ID: mdl-22579281

7.

Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils.

Murray, Kevin A; Hu, Carolyn J; Pan, Hope; Lu, Jiahui; Abskharon, Romany; Bowler, Jeannette T; Rosenberg, Gregory M; Williams, Christopher K; Elezi, Gazmend; Balbirnie, Melinda; Faull, Kym F; Vinters, Harry V; Seidler, Paul M; Eisenberg, David S.

Proc Natl Acad Sci U S A ; 120(7): e2217835120, 2023 02 14.

Artículo en Inglés | MEDLINE | ID: mdl-36757890

8.

Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.

Abskharon, Romany; Pan, Hope; Sawaya, Michael R; Seidler, Paul M; Olivares, Eileen J; Chen, Yu; Murray, Kevin A; Zhang, Jeffrey; Lantz, Carter; Bentzel, Megan; Boyer, David R; Cascio, Duilio; Nguyen, Binh A; Hou, Ke; Cheng, Xinyi; Pardon, Els; Williams, Christopher K; Nana, Alissa L; Vinters, Harry V; Spina, Salvatore; Grinberg, Lea T; Seeley, William W; Steyaert, Jan; Glabe, Charles G; Ogorzalek Loo, Rachel R; Loo, Joseph A; Eisenberg, David S.

Proc Natl Acad Sci U S A ; 120(41): e2300258120, 2023 10 10.

Artículo en Inglés | MEDLINE | ID: mdl-37801475

9.

Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.

Lu, Jiahui; Ge, Peng; Sawaya, Michael R; Hughes, Michael P; Boyer, David R; Cao, Qin; Abskharon, Romany; Cascio, Duilio; Tayeb-Fligelman, Einav; Eisenberg, David S.

J Biol Chem ; 300(2): 105531, 2024 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-38072051

10.

Propagation of Tau Aggregates and Neurodegeneration.

Goedert, Michel; Eisenberg, David S; Crowther, R Anthony.

Annu Rev Neurosci ; 40: 189-210, 2017 07 25.

Artículo en Inglés | MEDLINE | ID: mdl-28772101

11.

Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation.

Abskharon, Romany; Sawaya, Michael R; Boyer, David R; Cao, Qin; Nguyen, Binh A; Cascio, Duilio; Eisenberg, David S.

Proc Natl Acad Sci U S A ; 119(15): e2119952119, 2022 04 12.

Artículo en Inglés | MEDLINE | ID: mdl-35377792

12.

De novo designed protein inhibitors of amyloid aggregation and seeding.

Murray, Kevin A; Hu, Carolyn J; Griner, Sarah L; Pan, Hope; Bowler, Jeannette T; Abskharon, Romany; Rosenberg, Gregory M; Cheng, Xinyi; Seidler, Paul M; Eisenberg, David S.

Proc Natl Acad Sci U S A ; 119(34): e2206240119, 2022 08 23.

Artículo en Inglés | MEDLINE | ID: mdl-35969734

13.

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.

Vogler, Thomas O; Wheeler, Joshua R; Nguyen, Eric D; Hughes, Michael P; Britson, Kyla A; Lester, Evan; Rao, Bhalchandra; Betta, Nicole Dalla; Whitney, Oscar N; Ewachiw, Theodore E; Gomes, Edward; Shorter, James; Lloyd, Thomas E; Eisenberg, David S; Taylor, J Paul; Johnson, Aaron M; Olwin, Bradley B; Parker, Roy.

Nature ; 563(7732): 508-513, 2018 11.

Artículo en Inglés | MEDLINE | ID: mdl-30464263

14.

Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines.

Shipps, Catharine; Kelly, H Ray; Dahl, Peter J; Yi, Sophia M; Vu, Dennis; Boyer, David; Glynn, Calina; Sawaya, Michael R; Eisenberg, David; Batista, Victor S; Malvankar, Nikhil S.

Proc Natl Acad Sci U S A ; 118(2)2021 01 12.

Artículo en Inglés | MEDLINE | ID: mdl-33372136

15.

Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like ß-sheets.

Bowler, Jeannette T; Sawaya, Michael R; Boyer, David R; Cascio, Duilio; Bali, Manya; Eisenberg, David S.

J Biol Chem ; 298(10): 102396, 2022 10.

Artículo en Inglés | MEDLINE | ID: mdl-35988647

16.

Bioinformatic identification of previously unrecognized amyloidogenic proteins.

Rosenberg, Gregory M; Murray, Kevin A; Salwinski, Lukasz; Hughes, Michael P; Abskharon, Romany; Eisenberg, David S.

J Biol Chem ; 298(5): 101920, 2022 05.

Artículo en Inglés | MEDLINE | ID: mdl-35405097

17.

Racemic Peptides from Amyloid ß and Amylin Form Rippled ß-Sheets Rather Than Pleated ß-Sheets.

Hazari, Amaruka; Sawaya, Michael R; Sajimon, Maria; Vlahakis, Niko; Rodriguez, Jose; Eisenberg, David; Raskatov, Jevgenij A.

J Am Chem Soc ; 145(47): 25917-25926, 2023 11 29.

Artículo en Inglés | MEDLINE | ID: mdl-37972334

18.

A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms.

Sawaya, Michael R; Wojtowicz, Woj M; Andre, Ingemar; Qian, Bin; Wu, Wei; Baker, David; Eisenberg, David; Zipursky, S Lawrence.

Cell ; 134(6): 1007-18, 2008 Sep 19.

Artículo en Inglés | MEDLINE | ID: mdl-18805093

19.

Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.

Soragni, Alice; Yousefi, Shida; Stoeckle, Christina; Soriaga, Angela B; Sawaya, Michael R; Kozlowski, Evelyne; Schmid, Inès; Radonjic-Hoesli, Susanne; Boutet, Sebastien; Williams, Garth J; Messerschmidt, Marc; Seibert, M Marvin; Cascio, Duilio; Zatsepin, Nadia A; Burghammer, Manfred; Riekel, Christian; Colletier, Jacques-Philippe; Riek, Roland; Eisenberg, David S; Simon, Hans-Uwe.

Mol Cell ; 57(6): 1011-1021, 2015 Mar 19.

Artículo en Inglés | MEDLINE | ID: mdl-25728769

20.

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.

Boyer, David R; Li, Binsen; Sun, Chuanqi; Fan, Weijia; Zhou, Kang; Hughes, Michael P; Sawaya, Michael R; Jiang, Lin; Eisenberg, David S.

Proc Natl Acad Sci U S A ; 117(7): 3592-3602, 2020 02 18.

Artículo en Inglés | MEDLINE | ID: mdl-32015135

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