1.
J Med Chem
; 58(20): 8309-13, 2015 Oct 22.
Artículo
en Inglés
| MEDLINE
| ID: mdl-26356364
RESUMEN
As part of a program to develop a small molecule inhibitor of LIMK, a series of aminothiazole inhibitors were discovered by high throughput screening. Scaffold hopping and subsequent SAR directed development led to a series of low nanomolar inhibitors of LIMK1 and LIMK2 that also inhibited the direct biomarker p-cofilin in cells and inhibited the invasion of MDA MB-231-luc cells in a matrigel inverse invasion assay.