Improved prostate cancer diagnosis using a modified ResNet50-based deep learning architecture.

Prostate cancer, the most common cancer in men, is influenced by age, family history, genetics, and lifestyle factors. Early detection of prostate cancer using screening methods improves outcomes, but the balance between overdiagnosis and early detection remains debated. Using Deep Learning (DL) algorithms for prostate cancer detection offers a promising solution for accurate and efficient diagnosis, particularly in cases where prostate imaging is challenging. In this paper, we propose a Prostate Cancer Detection Model (PCDM) model for the automatic diagnosis of prostate cancer. It proves its clinical applicability to aid in the early detection and management of prostate cancer in real-world healthcare environments. The PCDM model is a modified ResNet50-based architecture that integrates faster R-CNN and dual optimizers to improve the performance of the detection process. The model is trained on a large dataset of annotated medical images, and the experimental results show that the proposed model outperforms both ResNet50 and VGG19 architectures. Specifically, the proposed model achieves high sensitivity, specificity, precision, and accuracy rates of 97.40%, 97.09%, 97.56%, and 95.24%, respectively.

Multilayer dynamic ensemble model for intensive care unit mortality prediction of neonate patients.

Robust and rabid mortality prediction is crucial in intensive care units because it is considered one of the critical steps for treating patients with serious conditions. Combining mortality prediction with the length of stay (LoS) prediction adds another level of importance to these models. No studies in the literature predict such tasks for neonates, especially using time-series data and dynamic ensemble techniques. Dynamic ensembles are novel techniques that dynamically select the base classifiers for each new case. Medically, implementing an accurate machine learning model is insufficient to gain the trust of physicians. The model must be able to justify its decisions. While explainable AI (XAI) techniques can be used to handle this challenge, no studies have been done in this regard for neonate monitoring in the neonatal intensive care unit (NICU). This study utilizes advanced machine learning approaches to predict mortality and LoS through data-driven learning. We propose a multilayer dynamic ensemble-based model to predict mortality as a classification task and LoS as a regression task for neonates admitted to the NICU. The model has been built based on the patient's time-series data of the first 24 h in the NICU. We utilized a cohort of 3,133 infants from the MIMIC-III real dataset to build and optimize the selected algorithms. It has shown that the dynamic ensemble models achieved better results than other classifiers, and static ensemble regressors achieved better results than classical machine learning regressors. The proposed optimized model is supported by three well-known explainability techniques of SHAP, decision tree visualization, and rule-based system. To provide online assistance to physicians in monitoring and managing neonates in the NICU, we implemented a web-based clinical decision support system based on the most accurate models and selected XAI techniques. The code of the proposed models is publicly available at https://github.com/InfoLab-SKKU/neonateMortalityPrediction.

Heterogeneous Ensemble Deep Learning Model for Enhanced Arabic Sentiment Analysis.

Sentiment analysis was nominated as a hot research topic a decade ago for its increasing importance in analyzing the people's opinions extracted from social media platforms. Although the Arabic language has a significant share of the content shared across social media platforms, its content's sentiment analysis is still limited due to its complex morphological structures and the varieties of dialects. Traditional machine learning and deep neural algorithms have been used in a variety of studies to predict sentiment analysis. Therefore, a need of changing current mechanisms is required to increase the accuracy of sentiment analysis prediction. This paper proposed an optimized heterogeneous stacking ensemble model for enhancing the performance of Arabic sentiment analysis. The proposed model combines three different of pre-trained Deep Learning (DL) models: Recurrent Neural Network (RNN), Long Short-Term Memory (LSTM), Gated Recurrent Unit (GRU) in conjunction with three meta-learners Logistic Regression (LR), Random Forest (RF), and Support Vector Machine (SVM) in order to enhance model's performance for predicting Arabic sentiment analysis. The performance of the proposed model with RNN, LSTM, GRU, and the five regular ML techniques: Decision Tree (DT), LR, K-Nearest Neighbor (KNN), RF, and Naive Bayes (NB) are compared using three benchmarks Arabic dataset. Parameters of Machine Learning (ML) and DL are optimized using Grid search and KerasTuner, respectively. Accuracy, precision, recall, and f1-score were applied to evaluate the performance of the models and validate the results. The results show that the proposed ensemble model has achieved the best performance for each dataset compared with other models.

Colon Cancer Diagnosis Based on Machine Learning and Deep Learning: Modalities and Analysis Techniques.

The treatment and diagnosis of colon cancer are considered to be social and economic challenges due to the high mortality rates. Every year, around the world, almost half a million people contract cancer, including colon cancer. Determining the grade of colon cancer mainly depends on analyzing the gland's structure by tissue region, which has led to the existence of various tests for screening that can be utilized to investigate polyp images and colorectal cancer. This article presents a comprehensive survey on the diagnosis of colon cancer. This covers many aspects related to colon cancer, such as its symptoms and grades as well as the available imaging modalities (particularly, histopathology images used for analysis) in addition to common diagnosis systems. Furthermore, the most widely used datasets and performance evaluation metrics are discussed. We provide a comprehensive review of the current studies on colon cancer, classified into deep-learning (DL) and machine-learning (ML) techniques, and we identify their main strengths and limitations. These techniques provide extensive support for identifying the early stages of cancer that lead to early treatment of the disease and produce a lower mortality rate compared with the rate produced after symptoms develop. In addition, these methods can help to prevent colorectal cancer from progressing through the removal of pre-malignant polyps, which can be achieved using screening tests to make the disease easier to diagnose. Finally, the existing challenges and future research directions that open the way for future work in this field are presented.

An Efficient 5G Data Plan Approach Based on Partially Distributed Mobility Architecture.

Reaching a flat network is the main target of future evolved packet core for the 5G mobile networks. The current 4th generation core network is centralized architecture, including Serving Gateway and Packet-data-network Gateway; both act as mobility and IP anchors. However, this architecture suffers from non-optimal routing and intolerable latency due to many control messages. To overcome these challenges, we propose a partially distributed architecture for 5th generation networks, such that the control plane and data plane are fully decoupled. The proposed architecture is based on including a node Multi-session Gateway to merge the mobility and IP anchor gateway functionality. This work presented a control entity with the full implementation of the control plane to achieve an optimal flat network architecture. The impact of the proposed evolved packet Core structure in attachment, data delivery, and mobility procedures is validated through simulation. Several experiments were carried out by using NS-3 simulation to validate the results of the proposed architecture. The Numerical analysis is evaluated in terms of total transmission delay, inter and intra handover delay, queuing delay, and total attachment time. Simulation results show that the proposed architecture performance-enhanced end-to-end latency over the legacy architecture.

A mobile health monitoring-and-treatment system based on integration of the SSN sensor ontology and the HL7 FHIR standard.

BACKGROUND: Mobile health (MH) technologies including clinical decision support systems (CDSS) provide an efficient method for patient monitoring and treatment. A mobile CDSS is based on real-time sensor data and historical electronic health record (EHR) data. Raw sensor data have no semantics of their own; therefore, a computer system cannot interpret these data automatically. In addition, the interoperability of sensor data and EHR medical data is a challenge. EHR data collected from distributed systems have different structures, semantics, and coding mechanisms. As a result, building a transparent CDSS that can work as a portable plug-and-play component in any existing EHR ecosystem requires a careful design process. Ontology and medical standards support the construction of semantically intelligent CDSSs. METHODS: This paper proposes a comprehensive MH framework with an integrated CDSS capability. This cloud-based system monitors and manages type 1 diabetes mellitus. The efficiency of any CDSS depends mainly on the quality of its knowledge and its semantic interoperability with different data sources. To this end, this paper concentrates on constructing a semantic CDSS based on proposed FASTO ontology. RESULTS: This realistic ontology is able to collect, formalize, integrate, analyze, and manipulate all types of patient data. It provides patients with complete, personalized, and medically intuitive care plans, including insulin regimens, diets, exercises, and education sub-plans. These plans are based on the complete patient profile. In addition, the proposed CDSS provides real-time patient monitoring based on vital signs collected from patients' wireless body area networks. These monitoring include real-time insulin adjustments, mealtime carbohydrate calculations, and exercise recommendations. FASTO integrates the well-known standards of HL7 fast healthcare interoperability resources (FHIR), semantic sensor network (SSN) ontology, basic formal ontology (BFO) 2.0, and clinical practice guidelines. The current version of FASTO includes 9577 classes, 658 object properties, 164 data properties, 460 individuals, and 140 SWRL rules. FASTO is publicly available through the National Center for Biomedical Ontology BioPortal at https://bioportal.bioontology.org/ontologies/FASTO . CONCLUSIONS: The resulting CDSS system can help physicians to monitor more patients efficiently and accurately. In addition, patients in rural areas can depend on the system to manage their diabetes and emergencies.

Fuzzy Ontology and LSTM-Based Text Mining: A Transportation Network Monitoring System for Assisting Travel.

Intelligent Transportation Systems (ITSs) utilize a sensor network-based system to gather and interpret traffic information. In addition, mobility users utilize mobile applications to collect transport information for safe traveling. However, these types of information are not sufficient to examine all aspects of the transportation networks. Therefore, both ITSs and mobility users need a smart approach and social media data, which can help ITSs examine transport services, support traffic and control management, and help mobility users travel safely. People utilize social networks to share their thoughts and opinions regarding transportation, which are useful for ITSs and travelers. However, user-generated text on social media is short in length, unstructured, and covers a broad range of dynamic topics. The application of recent Machine Learning (ML) approach is inefficient for extracting relevant features from unstructured data, detecting word polarity of features, and classifying the sentiment of features correctly. In addition, ML classifiers consistently miss the semantic feature of the word meaning. A novel fuzzy ontology-based semantic knowledge with Word2vec model is proposed to improve the task of transportation features extraction and text classification using the Bi-directional Long Short-Term Memory (Bi-LSTM) approach. The proposed fuzzy ontology describes semantic knowledge about entities and features and their relation in the transportation domain. Fuzzy ontology and smart methodology are developed in Web Ontology Language and Java, respectively. By utilizing word embedding with fuzzy ontology as a representation of text, Bi-LSTM shows satisfactory improvement in both the extraction of features and the classification of the unstructured text of social media.

SNOMED CT standard ontology based on the ontology for general medical science.

BACKGROUND: Systematized Nomenclature of Medicine-Clinical Terms (SNOMED CT, hereafter abbreviated SCT) is a comprehensive medical terminology used for standardizing the storage, retrieval, and exchange of electronic health data. Some efforts have been made to capture the contents of SCT as Web Ontology Language (OWL), but these efforts have been hampered by the size and complexity of SCT. METHOD: Our proposal here is to develop an upper-level ontology and to use it as the basis for defining the terms in SCT in a way that will support quality assurance of SCT, for example, by allowing consistency checks of definitions and the identification and elimination of redundancies in the SCT vocabulary. Our proposed upper-level SCT ontology (SCTO) is based on the Ontology for General Medical Science (OGMS). RESULTS: The SCTO is implemented in OWL 2, to support automatic inference and consistency checking. The approach will allow integration of SCT data with data annotated using Open Biomedical Ontologies (OBO) Foundry ontologies, since the use of OGMS will ensure consistency with the Basic Formal Ontology, which is the top-level ontology of the OBO Foundry. Currently, the SCTO contains 304 classes, 28 properties, 2400 axioms, and 1555 annotations. It is publicly available through the bioportal at http://bioportal.bioontology.org/ontologies/SCTO/ . CONCLUSION: The resulting ontology can enhance the semantics of clinical decision support systems and semantic interoperability among distributed electronic health records. In addition, the populated ontology can be used for the automation of mobile health applications.

An ontological case base engineering methodology for diabetes management.

Ontology engineering covers issues related to ontology development and use. In Case Based Reasoning (CBR) system, ontology plays two main roles; the first as case base and the second as domain ontology. However, the ontology engineering literature does not provide adequate guidance on how to build, evaluate, and maintain ontologies. This paper proposes an ontology engineering methodology to generate case bases in the medical domain. It mainly focuses on the research of case representation in the form of ontology to support the case semantic retrieval and enhance all knowledge intensive CBR processes. A case study on diabetes diagnosis case base will be provided to evaluate the proposed methodology.

A dynamic fuzzy rule-based inference system using fuzzy inference with semantic reasoning.

The challenge of making flexible, standard, and early medical diagnoses is significant. However, some limitations are not fully overcome. First, the diagnosis rules established by medical experts or learned from a trained dataset prove static and too general. It leads to decisions that lack adaptive flexibility when finding new circumstances. Secondly, medical terminological interoperability is highly critical. It increases realism and medical progress and avoids isolated systems and the difficulty of data exchange, analysis, and interpretation. Third, criteria for diagnosis are often heterogeneous and changeable. It includes symptoms, patient history, demographic, treatment, genetics, biochemistry, and imaging. Symptoms represent a high-impact indicator for early detection. It is important that we deal with these symptoms differently, which have a great relationship with semantics, vary widely, and have linguistic information. This negatively affects early diagnosis decision-making. Depending on the circumstances, the diagnosis is made solo on imaging and some medical tests. In this case, although the accuracy of the diagnosis is very high, can these decisions be considered an early diagnosis or prove the condition is deteriorating? Our contribution in this paper is to present a real medical diagnostic system based on semantics, fuzzy, and dynamic decision rules. We attempt to integrate ontology semantics reasoning and fuzzy inference. It promotes fuzzy reasoning and handles knowledge representation problems. In complications and symptoms, ontological semantic reasoning improves the process of evaluating rules in terms of interpretability, dynamism, and intelligence. A real-world case study, ADNI, is presented involving the field of Alzheimer's disease (AD). The proposed system has indicated the possibility of the system to diagnose AD with an accuracy of 97.2%, 95.4%, 94.8%, 93.1%, and 96.3% for AD, LMCI, EMCI, SMC, and CN respectively.

Explainable machine learning models based on multimodal time-series data for the early detection of Parkinson's disease.

BACKGROUND AND OBJECTIVES: Parkinson's Disease (PD) is a devastating chronic neurological condition. Machine learning (ML) techniques have been used in the early prediction of PD progression. Fusion of heterogeneous data modalities proved its capability to improve the performance of ML models. Time series data fusion supports the tracking of the disease over time. In addition, the trustworthiness of the resulting models is improved by adding model explainability features. The literature on PD has not sufficiently explored these three points. METHODS: In this work, we proposed an ML pipeline for predicting the progression of PD that is both accurate and explainable. We explore the fusion of different combinations of five time series modalities from the Parkinson's Progression Markers Initiative (PPMI) real-world dataset, including patient characteristics, biosamples, medication history, motor, and non-motor function data. Each patient has six visits. The problem has been formulated in two ways: ❶ a three-class based progression prediction with 953 patients in each time series modality, and ❷ a four-class based progression prediction with 1,060 patients in each time series modality. The statistical features of these six visits were calculated from each modality and diverse feature selection methods were applied to select the most informative feature sets. The extracted features were used to train a set of well-known ML models including Support vector machines (SVM), random forests (RF), extra tree classifier (ETC), light gradient boosting machines (LGBM), and stochastic gradient descent (SGD). We examined a number of data-balancing strategies in the pipeline with different combinations of modalities. ML models have been optimized using the Bayesian optimizer. A comprehensive evaluation of various ML methods has been conducted, and the best models have been extended to provide different explainability features. RESULTS: We compare the performance of ML models before and after optimization and using and without using feature selection. In the three-class experiment and with various modality fusions, the LGBM model produced the most accurate results with a 10-fold cross-validation (10-CV) accuracy of 90.73% using non-motor function modality. RF produced the best results in the four-class experiment with various modality fusions with a 10-CV accuracy of 94.57% using non-motor modality. With the fused dataset of non-motor and motor function modalities, the LGBM model outperformed the other ML models in both the 3-class and 4-class experiments (i.e., 10-CV accuracy of 94.89% and 93.73%, respectively). Using the Shapely Additive Explanations (SHAP) framework, we employed global and instance-based explanations to explain the behavior of each ML classifier. Moreover, we extended the explainability by implementing the LIME and SHAPASH local explainers. The consistency of these explainers has been explored. The resultant classifiers were accurate, explainable, and thus medically more relevant and applicable. CONCLUSIONS: The select modalities and feature sets were confirmed by the literature and medical experts. The various explainers suggest that the bradykinesia (NP3BRADY) feature was the most dominant and consistent. By providing thorough insights into the influence of multiple modalities on the disease risk, the suggested approach is expected to help improve the clinical knowledge of PD progression processes.

A Holistic Approach to Identify and Classify COVID-19 from Chest Radiographs, ECG, and CT-Scan Images Using ShuffleNet Convolutional Neural Network.

Early and precise COVID-19 identification and analysis are pivotal in reducing the spread of COVID-19. Medical imaging techniques, such as chest X-ray or chest radiographs, computed tomography (CT) scan, and electrocardiogram (ECG) trace images are the most widely known for early discovery and analysis of the coronavirus disease (COVID-19). Deep learning (DL) frameworks for identifying COVID-19 positive patients in the literature are limited to one data format, either ECG or chest radiograph images. Moreover, using several data types to recover abnormal patterns caused by COVID-19 could potentially provide more information and restrict the spread of the virus. This study presents an effective COVID-19 detection and classification approach using the Shufflenet CNN by employing three types of images, i.e., chest radiograph, CT-scan, and ECG-trace images. For this purpose, we performed extensive classification experiments with the proposed approach using each type of image. With the chest radiograph dataset, we performed three classification experiments at different levels of granularity, i.e., binary, three-class, and four-class classifications. In addition, we performed a binary classification experiment with the proposed approach by classifying CT-scan images into COVID-positive and normal. Finally, utilizing the ECG-trace images, we conducted three experiments at different levels of granularity, i.e., binary, three-class, and five-class classifications. We evaluated the proposed approach with the baseline COVID-19 Radiography Database, SARS-CoV-2 CT-scan, and ECG images dataset of cardiac and COVID-19 patients. The average accuracy of 99.98% for COVID-19 detection in the three-class classification scheme using chest radiographs, optimal accuracy of 100% for COVID-19 detection using CT scans, and average accuracy of 99.37% for five-class classification scheme using ECG trace images have proved the efficacy of our proposed method over the contemporary methods. The optimal accuracy of 100% for COVID-19 detection using CT scans and the accuracy gain of 1.54% (in the case of five-class classification using ECG trace images) from the previous approach, which utilized ECG images for the first time, has a major contribution to improving the COVID-19 prediction rate in early stages. Experimental findings demonstrate that the proposed framework outperforms contemporary models. For example, the proposed approach outperforms state-of-the-art DL approaches, such as Squeezenet, Alexnet, and Darknet19, by achieving the accuracy of 99.98 (proposed method), 98.29, 98.50, and 99.67, respectively.

A deep learning based dual encoder-decoder framework for anatomical structure segmentation in chest X-ray images.

Automated multi-organ segmentation plays an essential part in the computer-aided diagnostic (CAD) of chest X-ray fluoroscopy. However, developing a CAD system for the anatomical structure segmentation remains challenging due to several indistinct structures, variations in the anatomical structure shape among different individuals, the presence of medical tools, such as pacemakers and catheters, and various artifacts in the chest radiographic images. In this paper, we propose a robust deep learning segmentation framework for the anatomical structure in chest radiographs that utilizes a dual encoder-decoder convolutional neural network (CNN). The first network in the dual encoder-decoder structure effectively utilizes a pre-trained VGG19 as an encoder for the segmentation task. The pre-trained encoder output is fed into the squeeze-and-excitation (SE) to boost the network's representation power, which enables it to perform dynamic channel-wise feature calibrations. The calibrated features are efficiently passed into the first decoder to generate the mask. We integrated the generated mask with the input image and passed it through a second encoder-decoder network with the recurrent residual blocks and an attention the gate module to capture the additional contextual features and improve the segmentation of the smaller regions. Three public chest X-ray datasets are used to evaluate the proposed method for multi-organs segmentation, such as the heart, lungs, and clavicles, and single-organ segmentation, which include only lungs. The results from the experiment show that our proposed technique outperformed the existing multi-class and single-class segmentation methods.

Henry gas solubility optimization double machine learning classifier for neurosurgical patients.

This study aims to predict head trauma outcome for Neurosurgical patients in children, adults, and elderly people. As Machine Learning (ML) algorithms are helpful in healthcare field, a comparative study of various ML techniques is developed. Several algorithms are utilized such as k-nearest neighbor, Random Forest (RF), C4.5, Artificial Neural Network, and Support Vector Machine (SVM). Their performance is assessed using anonymous patients' data. Then, a proposed double classifier based on Henry Gas Solubility Optimization (HGSO) is developed with Aquila optimizer (AQO). It is implemented for feature selection to classify patients' outcome status into four states. Those are mortality, morbidity, improved, or the same. The double classifiers are evaluated via various performance metrics including recall, precision, F-measure, accuracy, and sensitivity. Another contribution of this research is the original use of hybrid technique based on RF-SVM and HGSO to predict patient outcome status with high accuracy. It determines outcome status relationship with age and mode of trauma. The algorithm is tested on more than 1000 anonymous patients' data taken from a Neurosurgical unit of Mansoura International Hospital, Egypt. Experimental results show that the proposed method has the highest accuracy of 99.2% (with population size = 30) compared with other classifiers.

Diagnosis of COVID-19 Using Chest X-ray Images and Disease Symptoms Based on Stacking Ensemble Deep Learning.

The COVID-19 virus is one of the most devastating illnesses humanity has ever faced. COVID-19 is an infection that is hard to diagnose until it has caused lung damage or blood clots. As a result, it is one of the most insidious diseases due to the lack of knowledge of its symptoms. Artificial intelligence (AI) technologies are being investigated for the early detection of COVID-19 using symptoms and chest X-ray images. Therefore, this work proposes stacking ensemble models using two types of COVID-19 datasets, symptoms and chest X-ray scans, to identify COVID-19. The first proposed model is a stacking ensemble model that is merged from the outputs of pre-trained models in the stacking: multi-layer perceptron (MLP), recurrent neural network (RNN), long short-term memory (LSTM), and gated recurrent unit (GRU). Stacking trains and evaluates the meta-learner as a support vector machine (SVM) to predict the final decision. Two datasets of COVID-19 symptoms are used to compare the first proposed model with MLP, RNN, LSTM, and GRU models. The second proposed model is a stacking ensemble model that is merged from the outputs of pre-trained DL models in the stacking: VGG16, InceptionV3, Resnet50, and DenseNet121; it uses stacking to train and evaluate the meta-learner (SVM) to identify the final prediction. Two datasets of COVID-19 chest X-ray images are used to compare the second proposed model with other DL models. The result has shown that the proposed models achieve the highest performance compared to other models for each dataset.

An Efficient Artificial Rabbits Optimization Based on Mutation Strategy For Skin Cancer Prediction.

Accurate skin lesion diagnosis is critical for the early detection of melanoma. However, the existing approaches are unable to attain substantial levels of accuracy. Recently, pre-trained Deep Learning (DL) models have been applied to tackle and improve efficiency on tasks such as skin cancer detection instead of training models from scratch. Therefore, we develop a robust model for skin cancer detection with a DL-based model as a feature extraction backbone, which is achieved using MobileNetV3 architecture. In addition, a novel algorithm called the Improved Artificial Rabbits Optimizer (IARO) is introduced, which uses the Gaussian mutation and crossover operator to ignore the unimportant features from those features extracted using MobileNetV3. The PH2, ISIC-2016, and HAM10000 datasets are used to validate the developed approach's efficiency. The empirical results show that the developed approach yields outstanding accuracy results of 87.17% on the ISIC-2016 dataset, 96.79% on the PH2 dataset, and 88.71 % on the HAM10000 dataset. Experiments show that the IARO can significantly improve the prediction of skin cancer.

Computer aided progression detection model based on optimized deep LSTM ensemble model and the fusion of multivariate time series data.

Alzheimer's disease (AD) is the most common form of dementia. Early and accurate detection of AD is crucial to plan for disease modifying therapies that could prevent or delay the conversion to sever stages of the disease. As a chronic disease, patient's multivariate time series data including neuroimaging, genetics, cognitive scores, and neuropsychological battery provides a complete profile about patient's status. This data has been used to build machine learning and deep learning (DL) models for the early detection of the disease. However, these models still have limited performance and are not stable enough to be trusted in real medical settings. Literature shows that DL models outperform classical machine learning models, but ensemble learning has proven to achieve better results than standalone models. This study proposes a novel deep stacking framework which combines multiple DL models to accurately predict AD at an early stage. The study uses long short-term memory (LSTM) models as base models over patient's multivariate time series data to learn the deep longitudinal features. Each base LSTM classifier has been optimized using the Bayesian optimizer using different feature sets. As a result, the final optimized ensembled model employed heterogeneous base models that are trained on heterogeneous data. The performance of the resulting ensemble model has been explored using a cohort of 685 patients from the University of Washington's National Alzheimer's Coordinating Center dataset. Compared to the classical machine learning models and base LSTM classifiers, the proposed ensemble model achieves the highest testing results (i.e., 82.02, 82.25, 82.02, and 82.12 for accuracy, precision, recall, and F1-score, respectively). The resulting model enhances the performance of the state-of-the-art literature, and it could be used to build an accurate clinical decision support tool that can assist domain experts for AD progression detection.

Predicting CTS Diagnosis and Prognosis Based on Machine Learning Techniques.

Carpal tunnel syndrome (CTS) is a clinical disease that occurs due to compression of the median nerve in the carpal tunnel. The determination of the severity of carpal tunnel syndrome is essential to provide appropriate therapeutic interventions. Machine learning (ML)-based modeling can be used to classify diseases, make decisions, and create new therapeutic interventions. It is also used in medical research to implement predictive models. However, despite the growth in medical research based on ML and Deep Learning (DL), CTS research is still relatively scarce. While a few studies have developed models to predict diagnosis of CTS, no ML model has been presented to classify the severity of CTS based on comprehensive clinical data. Therefore, this study developed new classification models for determining CTS severity using ML algorithms. This study included 80 patients with other diseases that have an overlap in symptoms with CTS, such as cervical radiculopathysasas, de quervian tendinopathy, and peripheral neuropathy, and 80 CTS patients who underwent ultrasonography (US)-guided median nerve hydrodissection. CTS severity was classified into mild, moderate, and severe grades. In our study, we aggregated the data from CTS patients and patients with other diseases that have an overlap in symptoms with CTS, such as cervical radiculopathysasas, de quervian tendinopathy, and peripheral neuropathy. The dataset was randomly split into training and test data, at 70% and 30%, respectively. The proposed model achieved promising results of 0.955%, 0.963%, and 0.919% in terms of classification accuracy, precision, and recall, respectively. In addition, we developed a machine learning model that predicts the probability of a patient improving after the hydro-dissection injection process based on the aggregated data after three different months (one, three, and six). The proposed model achieved accuracy after six months of 0.912%, after three months of 0.901%, and after one month 0.877%. The overall performance for predicting the prognosis after six months outperforms the prediction after one and three months. We utilized statistics tests (significance test, Spearman's correlation test, and two-way ANOVA test) to determine the effect of injection process in CTS treatment. Our data-driven decision support tools can be used to help determine which patients to operate on in order to avoid the associated risks and expenses of surgery.

Polycystic Ovary Syndrome Detection Machine Learning Model Based on Optimized Feature Selection and Explainable Artificial Intelligence.

Polycystic ovary syndrome (PCOS) has been classified as a severe health problem common among women globally. Early detection and treatment of PCOS reduce the possibility of long-term complications, such as increasing the chances of developing type 2 diabetes and gestational diabetes. Therefore, effective and early PCOS diagnosis will help the healthcare systems to reduce the disease's problems and complications. Machine learning (ML) and ensemble learning have recently shown promising results in medical diagnostics. The main goal of our research is to provide model explanations to ensure efficiency, effectiveness, and trust in the developed model through local and global explanations. Feature selection methods with different types of ML models (logistic regression (LR), random forest (RF), decision tree (DT), naive Bayes (NB), support vector machine (SVM), k-nearest neighbor (KNN), xgboost, and Adaboost algorithm to get optimal feature selection and best model. Stacking ML models that combine the best base ML models with meta-learner are proposed to improve performance. Bayesian optimization is used to optimize ML models. Combining SMOTE (Synthetic Minority Oversampling Techniques) and ENN (Edited Nearest Neighbour) solves the class imbalance. The experimental results were made using a benchmark PCOS dataset with two ratios splitting 70:30 and 80:20. The result showed that the Stacking ML with REF feature selection recorded the highest accuracy at 100 compared to other models.

An effective approach for plant leaf diseases classification based on a novel DeepPlantNet deep learning model.

Introduction: Recently, plant disease detection and diagnosis procedures have become a primary agricultural concern. Early detection of plant diseases enables farmers to take preventative action, stopping the disease's transmission to other plant sections. Plant diseases are a severe hazard to food safety, but because the essential infrastructure is missing in various places around the globe, quick disease diagnosis is still difficult. The plant may experience a variety of attacks, from minor damage to total devastation, depending on how severe the infections are. Thus, early detection of plant diseases is necessary to optimize output to prevent such destruction. The physical examination of plant diseases produced low accuracy, required a lot of time, and could not accurately anticipate the plant disease. Creating an automated method capable of accurately classifying to deal with these issues is vital. Method: This research proposes an efficient, novel, and lightweight DeepPlantNet deep learning (DL)-based architecture for predicting and categorizing plant leaf diseases. The proposed DeepPlantNet model comprises 28 learned layers, i.e., 25 convolutional layers (ConV) and three fully connected (FC) layers. The framework employed Leaky RelU (LReLU), batch normalization (BN), fire modules, and a mix of 3×3 and 1×1 filters, making it a novel plant disease classification framework. The Proposed DeepPlantNet model can categorize plant disease images into many classifications. Results: The proposed approach categorizes the plant diseases into the following ten groups: Apple_Black_rot (ABR), Cherry_(including_sour)_Powdery_mildew (CPM), Grape_Leaf_blight_(Isariopsis_Leaf_Spot) (GLB), Peach_Bacterial_spot (PBS), Pepper_bell_Bacterial_spot (PBBS), Potato_Early_blight (PEB), Squash_Powdery_mildew (SPM), Strawberry_Leaf_scorch (SLS), bacterial tomato spot (TBS), and maize common rust (MCR). The proposed framework achieved an average accuracy of 98.49 and 99.85in the case of eight-class and three-class classification schemes, respectively. Discussion: The experimental findings demonstrated the DeepPlantNet model's superiority to the alternatives. The proposed technique can reduce financial and agricultural output losses by quickly and effectively assisting professionals and farmers in identifying plant leaf diseases.