RESUMEN
A study on the possible association of maternal factors with testicular cancer was undertaken. Information was obtained from the mothers of testicular cancer cases (N = 37) and the mothers of men without the disease (N = 37). Comparisons were made between the two groups. The cases were collected from the records of nine hospitals, and the controls were selected from five Public Health Centers by individually matching the sex and the year of birth with the testicular cancer cases. The mothers of the cases had significantly fewer live births than the mothers of the controls (the adjusted odds ratio per live birth = 0.4, p = 0.02), when the five following variables had been simultaneously adjusted by the logistic regression analysis. Those five variables included the Quetelet's Index of mothers before pregnancy, the age at an index birth, the duration of breastfeeding for an index child, the birth order of an index child, and the number of induced abortions. The endogenous hormonal milieu of a mother may be associated with the occurrence of testicular cancer in her child.
PIP: A study on the possible association of maternal factors with testicular cancer was undertaken. Comparisons were made among 2 group of women: those mothers of testicular cancer cases (n=37) and those mothers of men without the disease (n=37). Cases were collected from the records of 9 hospitals, and controls were selected from 5 public health centers by individually matching the sex and year of birth with the testicular cancer cases. Mothers of the cases had significantly fewer livebirths than those mothers of the control group (the adjusted odds ratio per livebirths=0.4, p=0.02) when the 5 following variables were simultaneously adjusted by the logistic regression analysis: Quetelet's Index of mothers before pregnancy, age at index birth, duration of breastfeeding for an index child, birth order of an index child, and number of induced abortions. The endogenous hormonal milieu of a mother may also be associated with the occurrence of testicular cancer in her child. (author's modified)
Asunto(s)
Neoplasias Testiculares/epidemiología , Aborto Inducido , Adolescente , Adulto , Análisis de Varianza , Orden de Nacimiento , Lactancia Materna , Niño , Métodos Epidemiológicos , Femenino , Humanos , Japón , Masculino , Edad Materna , Persona de Mediana Edad , Madres , Embarazo , Análisis de Regresión , Factores de RiesgoRESUMEN
A right renal pelvic mass in a 72-year-old man was resected. The histologic appearance of the tumor was a mixture of tubular adenocarcinoma cells and hepatoid neoplastic cells, and there was a resemblance to hepatoid adenocarcinoma. The intraoperative level of serum alpha-fetoprotein (AFP) was calculated to be 2246 ng/ml, and the postoperative level ranges from 183.6 to 285.6 ng/ml. Lectin binding assays showed that the serum AFP was the hepatic carcinoma type. In a hepatoid portion, an iron-negative, brown to green pigment was positive for bile. Alpha-fetoprotein was immunohistochemically evident in the neoplastic cells. In addition to the hepatic differentiation, the tumor had differentiated into intestinal absorptive or pancreatobiliary tract cells, as deduced from the frequent presence of spicular bodies, a unique light microscopic feature equivalent to microvilli with an actin core. The hepatoid adenocarcinoma is a distinct type of AFP-producing carcinoma present in the organs with epithelium of endodermal origin. Hepatoid adenocarcinoma in the renal pelvis may arise from a metaplasia of neoplastic mesonephric cells into endodermal cells.