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1.

Interferon-Î³ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.

Simpson, Daniel S; Pang, Jiyi; Weir, Ashley; Kong, Isabella Y; Fritsch, Melanie; Rashidi, Maryam; Cooney, James P; Davidson, Kathryn C; Speir, Mary; Djajawi, Tirta M; Hughes, Sebastian; Mackiewicz, Liana; Dayton, Merle; Anderton, Holly; Doerflinger, Marcel; Deng, Yexuan; Huang, Allan Shuai; Conos, Stephanie A; Tye, Hazel; Chow, Seong H; Rahman, Arfatur; Norton, Raymond S; Naderer, Thomas; Nicholson, Sandra E; Burgio, Gaetan; Man, Si Ming; Groom, Joanna R; Herold, Marco J; Hawkins, Edwin D; Lawlor, Kate E; Strasser, Andreas; Silke, John; Pellegrini, Marc; Kashkar, Hamid; Feltham, Rebecca; Vince, James E.

Immunity ; 55(3): 423-441.e9, 2022 03 08.

Artículo en Inglés | MEDLINE | ID: mdl-35139355

2.

K29/K48-branched ubiquitin chains TRIP the alarm fueling neo-substrate degradation via the CRL2^VHL.

Magtoto, Charlene M; Feltham, Rebecca.

Mol Cell ; 81(7): 1363-1365, 2021 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-33798411

3.

Ion Man: GSDMD Punches Pores to Knock Out cGAS.

Feltham, Rebecca; Vince, James E.

Immunity ; 49(3): 379-381, 2018 09 18.

Artículo en Inglés | MEDLINE | ID: mdl-30231975

4.

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.

Liccardi, Gianmaria; Ramos Garcia, Laura; Tenev, Tencho; Annibaldi, Alessandro; Legrand, Arnaud J; Robertson, David; Feltham, Rebecca; Anderton, Holly; Darding, Maurice; Peltzer, Nieves; Dannappel, Marius; Schünke, Hannah; Fava, Luca L; Haschka, Manuel D; Glatter, Timo; Nesvizhskii, Alexey; Schmidt, Alexander; Harris, Philip A; Bertin, John; Gough, Peter J; Villunger, Andreas; Silke, John; Pasparakis, Manolis; Bianchi, Katiuscia; Meier, Pascal.

Mol Cell ; 73(3): 413-428.e7, 2019 02 07.

Artículo en Inglés | MEDLINE | ID: mdl-30598363

5.

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.

Jaco, Isabel; Annibaldi, Alessandro; Lalaoui, Najoua; Wilson, Rebecca; Tenev, Tencho; Laurien, Lucie; Kim, Chun; Jamal, Kunzah; Wicky John, Sidonie; Liccardi, Gianmaria; Chau, Diep; Murphy, James M; Brumatti, Gabriela; Feltham, Rebecca; Pasparakis, Manolis; Silke, John; Meier, Pascal.

Mol Cell ; 66(5): 698-710.e5, 2017 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-28506461

6.

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.

Klemm, Theresa; Ebert, Gregor; Calleja, Dale J; Allison, Cody C; Richardson, Lachlan W; Bernardini, Jonathan P; Lu, Bernadine Gc; Kuchel, Nathan W; Grohmann, Christoph; Shibata, Yuri; Gan, Zhong Yan; Cooney, James P; Doerflinger, Marcel; Au, Amanda E; Blackmore, Timothy R; van der Heden van Noort, Gerbrand J; Geurink, Paul P; Ovaa, Huib; Newman, Janet; Riboldi-Tunnicliffe, Alan; Czabotar, Peter E; Mitchell, Jeffrey P; Feltham, Rebecca; Lechtenberg, Bernhard C; Lowes, Kym N; Dewson, Grant; Pellegrini, Marc; Lessene, Guillaume; Komander, David.

EMBO J ; 39(18): e106275, 2020 09 15.

Artículo en Inglés | MEDLINE | ID: mdl-32845033

7.

RIPK1 ubiquitination: Evidence, correlations and the undefined.

Simpson, Daniel S; Gabrielyan, Anna; Feltham, Rebecca.

Semin Cell Dev Biol ; 109: 76-85, 2021 01.

Artículo en Inglés | MEDLINE | ID: mdl-32980239

8.

The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1ß Release.

Rashidi, Maryam; Simpson, Daniel S; Hempel, Anne; Frank, Daniel; Petrie, Emma; Vince, Angelina; Feltham, Rebecca; Murphy, Jane; Chatfield, Simon M; Salvesen, Guy S; Murphy, James M; Wicks, Ian P; Vince, James E.

J Immunol ; 203(3): 736-748, 2019 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-31209100

9.

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.

Haas, Tobias L; Emmerich, Christoph H; Gerlach, Björn; Schmukle, Anna C; Cordier, Stefanie M; Rieser, Eva; Feltham, Rebecca; Vince, James; Warnken, Uwe; Wenger, Till; Koschny, Ronald; Komander, David; Silke, John; Walczak, Henning.

Mol Cell ; 36(5): 831-44, 2009 Dec 11.

Artículo en Inglés | MEDLINE | ID: mdl-20005846

10.

IAPs limit activation of RIP kinases by TNF receptor 1 during development.

Moulin, Maryline; Anderton, Holly; Voss, Anne K; Thomas, Tim; Wong, Wendy Wei-Lynn; Bankovacki, Aleksandra; Feltham, Rebecca; Chau, Diep; Cook, Wendy D; Silke, John; Vaux, David L.

EMBO J ; 31(7): 1679-91, 2012 Apr 04.

Artículo en Inglés | MEDLINE | ID: mdl-22327219

11.

SPATA2 - Keeping the TNF signal short and sweet.

Feltham, Rebecca; Webb, Andrew I; Silke, John.

EMBO J ; 35(17): 1848-50, 2016 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-27470000

12.

Mind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death.

Simpson, Daniel S; Anderton, Holly; Yousef, Jumana; Vaibhav, Vineet; Cobbold, Simon A; Bandala-Sanchez, Esther; Kueh, Andrew J; Dagley, Laura F; Herold, Marco J; Silke, John; Vince, James E; Feltham, Rebecca.

PNAS Nexus ; 3(1): pgad438, 2024 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-38156288

13.

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

Feltham, Rebecca L; Moulin, Maryline; Vince, James E; Mace, Peter D; Wong, Wendy Wei-Lynn; Anderton, Holly; Day, Catherine L; Vaux, David L; Silke, John.

J Biol Chem ; 292(34): 14310, 2017 08 25.

Artículo en Inglés | MEDLINE | ID: mdl-28842477

14.

Design and characterization of a heterobifunctional degrader of KEAP1.

Chen, Hao; Nguyen, Nghi H; Magtoto, Charlene M; Cobbold, Simon A; Bidgood, Grace M; Meza Guzman, Lizeth G; Richardson, Lachlan W; Corbin, Jason; Au, Amanda E; Lechtenberg, Bernhard C; Feltham, Rebecca; Sutherland, Kate D; Grohmann, Christoph; Nicholson, Sandra E; Sleebs, Brad E.

Redox Biol ; 59: 102552, 2023 02.

Artículo en Inglés | MEDLINE | ID: mdl-36473314

15.

Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization.

Feltham, Rebecca; Bettjeman, Bodhi; Budhidarmo, Rhesa; Mace, Peter D; Shirley, Sarah; Condon, Stephen M; Chunduru, Srinivas K; McKinlay, Mark A; Vaux, David L; Silke, John; Day, Catherine L.

J Biol Chem ; 286(19): 17015-28, 2011 May 13.

Artículo en Inglés | MEDLINE | ID: mdl-21393245

16.

IAPS and ubiquitylation.

Feltham, Rebecca; Khan, Nufail; Silke, John.

IUBMB Life ; 64(5): 411-8, 2012 May.

Artículo en Inglés | MEDLINE | ID: mdl-22362579

17.

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms.

Grohmann, Christoph; Magtoto, Charlene M; Walker, Joel R; Chua, Ngee Kiat; Gabrielyan, Anna; Hall, Mary; Cobbold, Simon A; Mieruszynski, Stephen; Brzozowski, Martin; Simpson, Daniel S; Dong, Hao; Dorizzi, Bridget; Jacobsen, Annette V; Morrish, Emma; Silke, Natasha; Murphy, James M; Heath, Joan K; Testa, Andrea; Maniaci, Chiara; Ciulli, Alessio; Lessene, Guillaume; Silke, John; Feltham, Rebecca.

Nat Commun ; 13(1): 2073, 2022 04 19.

Artículo en Inglés | MEDLINE | ID: mdl-35440107

18.

Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death.

Frank, Daniel; Garnish, Sarah E; Sandow, Jarrod J; Weir, Ashley; Liu, Lin; Clayer, Elise; Meza, Lizeth; Rashidi, Maryam; Cobbold, Simon A; Scutts, Simon R; Doerflinger, Marcel; Anderton, Holly; Lawlor, Kate E; Lalaoui, Najoua; Kueh, Andrew J; Eng, Vik Ven; Ambrose, Rebecca L; Herold, Marco J; Samson, Andre L; Feltham, Rebecca; Murphy, James M; Ebert, Gregor; Pearson, Jaclyn S; Vince, James E.

iScience ; 25(7): 104632, 2022 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-35800780

19.

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

Feltham, Rebecca; Moulin, Maryline; Vince, James E; Mace, Peter D; Wong, Wendy Wei-Lynn; Anderton, Holly; Day, Catherine L; Vaux, David L; Silke, John.

J Biol Chem ; 285(23): 17525-36, 2010 Jun 04.

Artículo en Inglés | MEDLINE | ID: mdl-20356846

20.

The ubiquitylation of IL-1ß limits its cleavage by caspase-1 and targets it for proteasomal degradation.

Vijayaraj, Swarna L; Feltham, Rebecca; Rashidi, Maryam; Frank, Daniel; Liu, Zhengyang; Simpson, Daniel S; Ebert, Gregor; Vince, Angelina; Herold, Marco J; Kueh, Andrew; Pearson, Jaclyn S; Dagley, Laura F; Murphy, James M; Webb, Andrew I; Lawlor, Kate E; Vince, James E.

Nat Commun ; 12(1): 2713, 2021 05 11.

Artículo en Inglés | MEDLINE | ID: mdl-33976225

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Interferon-Î³ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.

K29/K48-branched ubiquitin chains TRIP the alarm fueling neo-substrate degradation via the CRL2^VHL.

Ion Man: GSDMD Punches Pores to Knock Out cGAS.

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.

RIPK1 ubiquitination: Evidence, correlations and the undefined.

The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1ß Release.

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.

IAPs limit activation of RIP kinases by TNF receptor 1 during development.

SPATA2 - Keeping the TNF signal short and sweet.

Mind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death.

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

Design and characterization of a heterobifunctional degrader of KEAP1.

Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization.

IAPS and ubiquitylation.

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms.

Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death.

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

The ubiquitylation of IL-1ß limits its cleavage by caspase-1 and targets it for proteasomal degradation.