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1.
Zhongguo Zhong Xi Yi Jie He Za Zhi ; 33(4): 476-9, 2013 Apr.
Artículo en Zh | MEDLINE | ID: mdl-23841266

RESUMEN

OBJECTIVE: To observe the therapeutic efficacy of guiling pa'an granule (GPG) in treating non-motor symptoms of Parkinson's disease (PD) patients of Gan-Shen deficiency syndrome (GSDS). METHODS: A multi-center,third party-central online, network randomized, double-blinded, double-dummy, and placebo controlled clinical trial was conducted. Totally 121 patients with confirmed diagnosis of PD by Western medicine and of GSDS by syndrome typing were assigned to the control group and the treatment group. Under the premise of the same treatment baseline, the placebo and GPG at the same dose was respectively administered to patients in the control group and the treatment group. The therapeutic course was 6 months for all. The changes of 8 non-motor symptoms (including witless expression, seborrhea, sialorrhea, cognitive impairment, constipation, hyperhidrosis, insomnia and dreaminess, and psychosis) were observed in the two groups, when compared with the baseline. RESULTS: Satisfactory effectiveness in the 8 non-motor symptoms of PD patients were obtained in the treatment group (P<0.01). Besides, less adverse reactions occurred. CONCLUSION: GPG could improve the non-motor symptoms of PD patients.


Asunto(s)
Medicamentos Herbarios Chinos/uso terapéutico , Enfermedad de Parkinson/tratamiento farmacológico , Fitoterapia , Anciano , Anciano de 80 o más Años , Método Doble Ciego , Femenino , Humanos , Masculino , Medicina Tradicional China , Persona de Mediana Edad , Enfermedad de Parkinson/diagnóstico , Resultado del Tratamiento
2.
Chin J Integr Med ; 27(5): 369-374, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-33000415

RESUMEN

OBJECTIVE: To observe the effects and safety of Tongyan Spray () on the range and time of hyoid motion in patients with ischemic post-stroke dysphagia. METHODS: Seventy-two patients with ischemic post-stroke dysphagia were selected and randomly assigned to a treatment group (36 cases) and a control group (36 cases) by a random number table from January 2013 to October 2014. All patients swallowed 4 kinds of barium meals with different traits respectively, and each patient underwent video fluoroscopy (VF) examination twice. In the treatment group, Tongyan Spray was sprayed to the pharynx on both sides and the middle part once respectively. The spray was applied 30 min before the second examination. Purified water at room temperature was used as placebo in the control group. The changes in the range and time of hyoid motion in both groups were observed before and after treatment. RESULTS: Six patients dropped out in each group, and 60 patients completed the study and were included in the final analysis. Significant improvement was observed in the range of superior hyoid excursion distance and the time of hyoid motion in the treatment group compared with the control group (P<0.05). There were no obvious adverse reactions observed in oral mucosa in both groups during the whole study. CONCLUSION: Tongyan Spray was an effective and safe medicine for improving swallowing function in patients with ischemic post-stroke dysphagia.


Asunto(s)
Isquemia Encefálica , Trastornos de Deglución , Accidente Cerebrovascular Isquémico , Isquemia Encefálica/complicaciones , Isquemia Encefálica/tratamiento farmacológico , Deglución , Trastornos de Deglución/tratamiento farmacológico , Trastornos de Deglución/etiología , Humanos , Hueso Hioides/diagnóstico por imagen , Accidente Cerebrovascular Isquémico/complicaciones
3.
Zhongguo Zhong Xi Yi Jie He Za Zhi ; 24(2): 143-6, 2004 Feb.
Artículo en Zh | MEDLINE | ID: mdl-15015450

RESUMEN

OBJECTIVE: To observe the effect of Yirong Oral Liquid (YROL) on reperfusion injury in rats with cerebral infarction undergoing thrombolysis. METHODS: Clinical reperfusion under thrombolysis was simulated by applying thrombolysis on reversible local cerebral ischemic rat model. In the rat model, effect of YROL on parameters concerning anti-oxidation capability, cerebral edema and ultrastructure of brain were observed. RESULTS: YROL could alleviate the cerebral edema after reperfusion, markedly increase the activity of superoxide dismutase in blood plasma, decrease the content of malonyldialdehyde, inhibit the post-reperfusion lipid peroxidation, and significantly reduce the ischemia/reperfusion injury of nerve cells in brain of rat. CONCLUSION: YROL has definite protecting effect on brain.


Asunto(s)
Infarto Cerebral/tratamiento farmacológico , Medicamentos Herbarios Chinos/uso terapéutico , Fármacos Neuroprotectores , Fitoterapia , Daño por Reperfusión/prevención & control , Terapia Trombolítica , Animales , Infarto Cerebral/patología , Quimioterapia Combinada , Masculino , Malondialdehído/sangre , Fármacos Neuroprotectores/uso terapéutico , Ratas , Ratas Sprague-Dawley , Superóxido Dismutasa/sangre , Activador de Plasminógeno de Tipo Uroquinasa/uso terapéutico
4.
Chin J Integr Med ; 18(5): 345-9, 2012 May.
Artículo en Inglés | MEDLINE | ID: mdl-22426799

RESUMEN

OBJECTIVE: To observe the effectiveness and safety of Tongyan spray composed of Chinese medicine for post-stroke dysphagia patients. METHOD: One hundred and twenty-two post-stroke dysphagia patients were randomly assigned to the treatment group (61 cases) and the control group (61 cases). Basic treatment was given to both groups, with Tongyan spray additionally used in oropharynx for the treatment group, and the placebo used for the control group. After 28-day treatment, the clinical effect and safety were evaluated according to the standard swallowing assessment (SSA) scale. RESULTS: One patient dropped out in each group, and 120 patients reached the final analysis of the study. The total effective rate for the treatment group was 71.7% (43/60), higher than 46.7% (28/60) in the control group (P<0.05), and the improvement on SSA scores of the two groups were significantly different after treatment (P<0.05). For grade 1 dysphagia patients (completely depending on nasogastric tube), the effective rate of the treatment group was 40.9% (9/22), and 12.5% (2/16) of the control group, without significant difference (P>0.05), while the improvement of SSA score was significantly different between the two groups after treatment (P<0.05). For grade 2-3 dysphagia patients (oral and nasogastric tube feeding), the total effective rate of the treatment group was 89.5% (34/38), higher than 59.1% (26/44) in the control group (P<0.05), and also the improvement on SSA scores was significantly different between the two groups after treatment (P<0.05). CONCLUSION: Tongyan spray was an effective and safe method for post-stroke dysphagia patients.


Asunto(s)
Clematis/química , Trastornos de Deglución/tratamiento farmacológico , Trastornos de Deglución/etiología , Medicamentos Herbarios Chinos/administración & dosificación , Accidente Cerebrovascular/complicaciones , Zingiber officinale/química , Administración por Inhalación , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Resultado del Tratamiento
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