RESUMEN
PURPOSE: Various segmentation methods for 18F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT) images were correlated with pathological volume in breast cancer patients as a model of small mobile tumours. METHODS: Thirty women with T2-T3/M0 breast invasive ductal carcinoma (IDC) were included prospectively. A FDG-PET/CT was acquired 4 ± 3d before surgery in prone and supine positions, with/without respiratory gating. The segmentation methods were as follows: manual (Vm), relative (Vt%) and adaptive (Va) standard uptake value (SUV) threshold and semi-automatic on CT (Vct). Pathological volumes (Vpath) were measured for 26 lesions. RESULTS: The mean (±SD) Vpath was 4.1 ± 2.9 mL, and the lesion displacements were 3.9 ± 2.8 mm (median value: 3 mm). The delineated VOIs did not vary with the acquisition position nor with respiration, regardless of the segmentation method. The Vm, Va, Vct and Vt% methods, except Vt30%, were correlated with Vpath (0.5Asunto(s)
Neoplasias de la Mama/diagnóstico
, Carcinoma Ductal de Mama/diagnóstico
, Fluorodesoxiglucosa F18
, Tomografía de Emisión de Positrones/métodos
, Radiofármacos
, Tomografía Computarizada por Rayos X/métodos
, Adulto
, Anciano
, Anciano de 80 o más Años
, Mama/diagnóstico por imagen
, Mama/patología
, Neoplasias de la Mama/patología
, Carcinoma Ductal de Mama/patología
, Femenino
, Humanos
, Mamografía/métodos
, Persona de Mediana Edad
, Imagen Multimodal/métodos
, Estudios Prospectivos
, Carga Tumoral